Determination of tartrazine and sodium benzoate as food additives in some local juices using continuous flow injection analysis

Hashim, Kadhim K.; Al-Rashidy, Asmaa Ahmed Mohmmed Al-Ahmed; Al-Samrrai, Shatha Y.

doi:10.1016/j.eaef.2019.01.002

Cited by 8 publications

(6 citation statements)

References 27 publications

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“…To monitor these intake limits, numerous analytical methods have been designed for the detection of SB, including NMR, electrochemical methods, liquid chromatography and spectrophotometry etc . 6–8 All the above-reported methods are complex, take a lot of time, and also require various equipment. Thus, a highly sensitive and selective sensor that is simple to use is required.…”

Section: Introductionmentioning

confidence: 99%

MIP integrated surface plasmon resonance in vitro detection of sodium benzoate

Maurya

Verma

2023

Analyst

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Section: Introductionmentioning

confidence: 99%

MIP integrated surface plasmon resonance in vitro detection of sodium benzoate

Maurya

Verma

2023

Analyst

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“…3,6 Previous research suggested that Tartrazine could be particularly detrimental to reproductive function, 7 where the daily administration of Tartrazine can reach 300 mg/kg. [8][9][10] The quantity of harmful Tartrazine colour residue was determined in a variety of beverages and foods using square-wave anodic stripping voltammetry on nanosheets G-C3N4/CPE. 11 Mandarin Leave-scrapped AuNPs sensor and Starch-capped ZnSNPs sensor were also used as a potential biosensor for Tartrazine colour measurement.…”

Section: Introductionmentioning

confidence: 99%

The protective effect of aqueous extract ofStevia rebaudianaagainst tartrazine toxicity in male Wistar rat

Hanna,

Beshay,

El. Shafee

et al. 2023

Cell Biochemistry & Function

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Tartrazine is a yellow colouring agent that is commonly used in foods; however, high dosages of Tartrazine affect fertility and create oxidative stress by generating free radicals. A plant species known as Stevia rebaudiana has natural antioxidants that show promise for protecting testicular tissue. Consequently, this study was intended to examine the ameliorative effect of the aqueous extract of S. rebaudiana (Stevia) on the fertility of male Wistar rats induced by the daily oral intake of Tartrazine. Utilizing gas chromatography–mass spectrometry, phytochemical identification was accomplished for Stevia extract. Study groups were separated into several groups: the first group (the control) got distilled water for up to 56 days; the Stevia group (1000 mg/kg), the Tartrazine group (300 mg/kg) and the Stevia and Tartrazine group (the group was given Tartrazine after 1 h of Stevia extract intake). Also, the oxidative damage in testicular tissues was assessed by measuring the levels of malondialdehyde (MDA) and antioxidants (catalase [CAT], superoxide dismutase [SOD] and glutathione reductase [GSH]). Further, histological alterations were examined. In addition, cyclic AMP‐responsive element modulator (Crem) gene expression levels and their relative proteins were measured in the testicular tissues using quantitative real‐time polymerase chain reaction and enzyme‐linked immunosorbent assays, respectively. Sperm analysis and testosterone concentration were also performed. SPSS version 25 was used for the analysis of results while (p < .05) was regarded as significant. Compared with the control group, the results demonstrated that Tartrazine caused a significant reduction (p < .05) in the testosterone hormone level (0.70 ± 0.21) and the Crem protein quantity (1.21 ± 0.23) in the treated Tartrazine group. Also, it had a significant decrease (p < .05) in sperm motility, viability, count and antioxidant levels. Moreover, there was a significant increase (p < .05) in sperm abnormalities, MDA level (7.40 ± 1.10), kidney and liver function parameters, and DNA degradation in the treated Tartrazine group compared with the control group. On the contrary, the Stevia extract intake enhanced the testosterone (2.50 ± 0.60), antioxidants and Crem protein levels (2.33 ± 0.10) with an improvement in sperm quality in the Stevia and Tartrazine‐treated group compared with the Tartrazine group. Stevia also caused a significant decrease (p < .05) in the MDA level (3.20 ± 0.20), and sperm abnormalities with an enhancement of the liver and kidney function parameters in the Stevia and Tartrazine‐treated group compared to the Tartrazine group. Stevia administration has a protective effect on the testicular tissues and sperm quality against toxicity induced by Tartrazine exposure, so it will be a good antioxidant drug to be administered daily before daily administration of Tartrazine.

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“…2–4 However, the aromatic ring structure and azo (–NN–) functional group of tartrazine compel people to investigate its potential harmful effects on human beings. As a result, studies have revealed that tartrazine is related to childhood asthma and urticaria, 5 attention deficit-hyperactivity disorder, 6 chromosome and DNA damage, 7 sperm malformation, 8 cyto-architecture disruptions and distortions 9 and so on. Consequently, the maximum allowed added amount of tartrazine is 0.1 g kg −1 in soft drinks (National Standard GB2760-2014-21, “standards of using food additives”), and its allowable daily intake is 7.5 mg kg −1 every day.…”

Section: Introductionmentioning

confidence: 99%

“…To date, several methods have been developed to detect tartrazine in real samples, such as UV-Vis spectrophotometry, 11 electrochemical method, 12,13 molecularly imprinted polymers, 8 high-performance liquid chromatography methods, 14 immunoassay, 10 continuous flow injection analysis, 5 surface-enhanced Raman spectroscopy, 15 fluorescence assays 2,16–18 and so on. Among these methods, fluorescence assays endow advantages in terms of selectivity, sensitivity, signal stability and simple operation in practical applications.…”

Section: Introductionmentioning

confidence: 99%