Determination of ten anti-inflammatory drugs in serum by isocratic liquid chromatography

Omile, C. I.; Tebbett, Ian R.; Danesh, B. J. Z.

doi:10.1007/bf02257324

Cited by 10 publications

(2 citation statements)

References 2 publications

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“…The experimental conditions, adapted from (34), are shown in Table I. When necessary, samples were diluted with deionized (DI) water or PBS as appropriate.…”

Section: Phase Solubility Studiesmentioning

confidence: 99%

Experimental and Computational Studies of Physicochemical Properties Influence NSAID-Cyclodextrin Complexation

Felton

Popescu²,

Wiley

et al. 2014

AAPS PharmSciTech

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Abstract. The objective of this research was to investigate physicochemical properties of an active pharmaceutical ingredient (API) that influence cyclodextrin complexation through experimental and computational studies. Native β-cyclodextrin (B-CD) and two hydroxypropyl derivatives were first evaluated by conventional phase solubility experiments for their ability to complex four poorly watersoluble nonsteroidal anti-inflammatory drugs (NSAIDs). Differential scanning calorimetry was used to confirm complexation. Secondly, molecular modeling was used to estimate Log P and aqueous solubility (S o ) of the NSAIDs. Molecular dynamics simulations (MDS) were used to investigate the thermodynamics and geometry of drug-CD cavity docking. NSAID solubility increased linearly with increasing CD concentration for the two CD derivatives (displaying an A L profile), whereas increases in drug solubility were low and plateaued in the B-CD solutions (type B profile). The calculated Log P and S o of the NSAIDs were in good concordance with experimental values reported in the literature. Side chain substitutions on the B-CD moiety did not significantly influence complexation. Explicitly, complexation and the associated solubility increase were mainly dependent on the chemical structure of the NSAID. MDS indicated that each NSAID-CD complex had a distinct geometry. Moreover, complexing energy had a large, stabilizing, and fairly constant hydrophobic component for a given CD across the NSAIDs, while electrostatic and solvation interaction complex energies were quite variable but smaller in magnitude.

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“…The experimental conditions, adapted from (34), are shown in Table I. When necessary, samples were diluted with deionized (DI) water or PBS as appropriate.…”

Section: Phase Solubility Studiesmentioning

confidence: 99%

Experimental and Computational Studies of Physicochemical Properties Influence NSAID-Cyclodextrin Complexation

Felton

Popescu²,

Wiley

et al. 2014

AAPS PharmSciTech

View full text Add to dashboard Cite

show abstract

“…These meth ods are in gen eral time con sum ing, la bor in ten sive and more im por tantly lack the spec i fic ity for a high con fi dence in iden ti fi ca tion. Re cently, meth ods based on high per for mance liq uid chro ma tog ra phy (HPLC) [1][2][3] and capil lary elec tro pho re sis (CE) [4][5][6] have been de vel oped for the anal y sis of syn thetic drugs in tra di tional Chi nese med i cine. A va ri ety of de tec tion tech niques, such as UV, flu o res cence, and elec tro chem i cal meth ods have been de vel oped for HPLC and CE.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Synthetic Drugs in Chinese Medicine by High Performance Liquid Chromatography/Mass Spectrometry with In‐Source Collision Induced Dissociation

Song

Cheng

Her

et al. 2000

J Chinese Chemical Soc

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Sixteen chemical drugs, often found in adulterated Chinese medicine, were studied by high performance liquid chromatography/atmospheric ionization mass spectrometry. Under optimal conditions, three pairs of compounds were either coeluted or unresolved. The lack of chromatographic resolution and the lack of specificity in UV detection were overcome by a method based on high performance liquid chromatography/ electrospray mass spectrometry. This method was capable of detecting the adulterants based on their retention times, molecular ions, and characteristic fragments resulting from in-source collision induced dissociation. EXPERIMENTAL ChemicalsAll chemical drugs, acetaminophen, bucetin, caffeine, diazepam, ethoxybenzamide, fenbufen, flufenamic acid, indomethacine, ketoprofen, mefenamic acid, niflumic acid, oxyphenbutazone, phenylbutazone, prednisolone, salicylamide and sulindac were obtained from Laboratories of Foods

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High resolution gas chromatography determination of twelve acidic non‐steroidal antiinflammatory drugs (NSAIDs) as methyl ester derivatives in plasma

Giachetti¹,

Zanolo²,

Poletti³

et al. 1990

J. High Resol. Chromatogr.

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Determination of ten anti-inflammatory drugs in serum by isocratic liquid chromatography

Cited by 10 publications

References 2 publications

Experimental and Computational Studies of Physicochemical Properties Influence NSAID-Cyclodextrin Complexation

Experimental and Computational Studies of Physicochemical Properties Influence NSAID-Cyclodextrin Complexation

Analysis of Synthetic Drugs in Chinese Medicine by High Performance Liquid Chromatography/Mass Spectrometry with In‐Source Collision Induced Dissociation

High resolution gas chromatography determination of twelve acidic non‐steroidal antiinflammatory drugs (NSAIDs) as methyl ester derivatives in plasma

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