Determination of terbinafine (Lamisil�) in human hair by microbore liquid chromatography/tandem mass spectrometry

Majumdar, Tapan; Bakhtiar, Ray; Melamed, D B; Tse, Francis L. S.

doi:10.1002/1097-0231(20000730)14:14<1214::aid-rcm12>3.0.co;2-5

Cited by 18 publications

(6 citation statements)

References 19 publications

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“…The hair was placed immediately in 50 mL conical Eppendorf tubes (Fisher Scientific, Pittsburgh, PA, USA) and stored at –20 °C for no longer than 6 months until high‐performance liquid chromatography (HPLC) analysis. Majumdar et al 16 . reported that no discernible loss was observed after storage at –20 °C for 9 months of human hair samples spiked with terbinafine.…”

Section: Methodsmentioning

confidence: 99%

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Evaluation of persistence of terbinafine in the hair of normal cats after 14 days of daily therapy

Foust¹,

Marsella²,

Akucewich³

et al. 2007

Veterinary Dermatology

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This study determined the residual concentration of terbinafine in cat hair after 14 days of oral treatment. Ten clinically normal cats were administered terbinafine orally at a daily dose of 34-45.7 mg kg(-1) for a total of 14 days. Areas of 15 cm(2) were shaved on the lateral thorax at day 0 and weekly for 8 weeks after the last dose of terbinafine. The hair samples were analysed by high-pressure liquid chromatography to determine the persistence of terbinafine over time. The mean terbinafine concentration in hair was 2.30 ng mg(-1) after 14 days of therapy. The half life was 1.84 weeks after the last dose of terbinafine. With a 99% confidence interval, the concentration of terbinafine remained in the cat hair at or above 0.03 ng mg(-1) (minimal inhibitory concentration (MIC)(90) = 0.03 microg mL(-1)) for 5.3 weeks. Slight deviations in the complete blood cell count and serum chemistry values were not attributed to terbinafine. Four cats experienced vomiting during the terbinafine treatment; two of these cats also experienced intense facial pruritus followed by a macular to papular skin reaction 7-14 days after the discontinuation of terbinafine. In summary, terbinafine persists in hair at concentrations above the MIC for several weeks after stopping medication, even after short-term therapy (14 days). These results suggest that pulse therapy of terbinafine should be further researched and potentially considered as a treatment modality for feline dermatophytosis, an approach that would decrease treatment duration while maintaining effectiveness.

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Section: Methodsmentioning

confidence: 99%

“…Majumdar et al . 16 reported that no discernible loss was observed after storage at -20 ° C for 9 months of human hair samples spiked with terbinafine.…”

Section: Collection Of Samplesmentioning

confidence: 99%

Evaluation of persistence of terbinafine in the hair of normal cats after 14 days of daily therapy

Foust¹,

Marsella²,

Akucewich³

et al. 2007

Veterinary Dermatology

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“…Over the last two decades several methods are reported to determine terbinafine in a variety of matrices such as cat hair (Kuz̆ner, Koz̆uh Erz̆en, & Drobnic̆‐Kos̆orok, ), rat tissue (Yeganeh & McLachlan, ), parrot plasma and saline (Cox et al, ), minipig plasma (Brignol, Bakhtiar, Dou, Majumdar, & Tse, ), human hair (Majumdar, Bakhtiar, Melamed, & Tse, ), human serum (Wang et al, ) and human plasma (Belal, El‐Din, Eid, & El‐Gamal, ; Brignol et al, ; de Oliveira et al, ; Dotsikas, Apostolou, Kousoulos, Tsatsou, & Loukas, ; Gurule, Khuroo, Monif, Goswami, & Saha, ; Koytchev, Erenmemisoglu, van der Meer, & Alpan, ; UnalOzer, ). Other methods describe the simultaneous determination of terbinafine together with its metabolites (Crego, Gómez, & Lavandera, ) and with other antifungal, diuretic and antibacterial drugs (Baranowska, Wilczek, & Baranowski, ).…”

Section: Introductionmentioning

confidence: 99%

“…Other methods describe the simultaneous determination of terbinafine together with its metabolites (Crego, Gómez, & Lavandera, ) and with other antifungal, diuretic and antibacterial drugs (Baranowska, Wilczek, & Baranowski, ). These methods have used various analytical techniques such as voltammetry (Wang et al, ), capillary electrophoresis (Crego et al, ), gas chromatography (Kuz̆ner et al, ), high‐performance liquid chromatography (HPLC) with ultraviolet (UV) (Baranowska et al, ; Cox et al, ; Jiang et al, ; Kuz̆ner et al, ; UnalOzer, ; Yeganeh & McLachlan, ) and fluorescence detection (Belal et al, ), ultra‐performance liquid chromatography (UPLC)–UV (Baranowska et al, ; UnalOzer, ) and liquid chromatography–tandem mass spectrometry (LC–MS/MS) (Almeida et al, ; Brignol et al, ; de Oliveira et al, ; Dotsikas et al, ; Gurule et al, ; Koytchev et al, ; Majumdar et al, ). Apart from two reports (Brignol et al, ; de Oliveira et al, ), all other methods are less sensitive (≥5.0 ng/mL) (Almeida et al, ; Baranowska et al, ; Belal et al, ; Dotsikas et al, ; Gurule et al, ; Jiang et al, ; Koytchev et al, ; UnalOzer, ), have long analysis time (≥5.0 min) (Belal et al, ; Brignol et al, ; de Oliveira et al, ; UnalOzer, ) or require large sample volumes (≥500 μL) for processing (Baranowska et al, ; Belal et al, ; Gurule et al, ; UnalOzer, ).…”

Section: Introductionmentioning

confidence: 99%

Determination of terbinafine in human plasma using UPLC–MS/MS: Application to a bioequivalence study in healthy subjects

Bhadoriya

Shah

Shrivastav

et al. 2019

Biomedical Chromatography

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A high-throughput and sensitive ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method has been developed for the determination of terbinafine in human plasma. The method employed liquid-liquid extraction of terbinafine and terbinafine-d7 (used as internal standard) from 100 μL human plasma with ethyl acetate-n-hexane (80:20, v/v) solvent mixture. Chromatography was performed on a BEH C 18 (50 × 2.1 mm, 1.7 μm) column using acetonitrile-8.0 mM ammonium formate, pH 3.5 (85:15, v/v) under isocratic elution. For quantitative analysis, MS/MS ion transitions were monitored at m/z 292.2/141.1 and m/z 299.1/148.2 forterbinafine and terbinafine-d7, respectively, using electrospray ionization in the positive mode. The method was validated according to regulatory guidance for selectivity, sensitivity, linearity, recovery, matrix effect, stability, dilution reliability and ruggedness with acceptable accuracy and precision. The method shows good linearity over the tested concentration range from 1.00 to 2000 ng/mL (r 2 ≥ 0.9984). The intra-batch and inter-batch precision (CV) was 1.8-3.2 and 2.1-4.5%, respectively. The method was successfully applied to a bioequivalence study with 250 mg terbinafine in 32 healthy subjects. The major advantage of this method includes higher sensitivity, small plasma volume for processing and a short analysis time. KEYWORDSbioequivalence study, human plasma, liquid-liquid extraction, terbinafine, terbinafine-d7, UPLC- MS/MS

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“…At present, a number of analytical methods have been published for determining terbinafine raw material such as titrimetry in non‐aqueous solvent, voltammetry, ultraviolet (UV) spectrophotometric method, and capillary electrophoresis . Moreover, terbinafine has been determined in biological fluids by high‐performance liquid chromatography (HPLC) technique and microbiological bioassay . HPLC methods have also been used for determining the drug in tablet and cream forms .…”

Section: Introductionmentioning

confidence: 99%

Extracting trace amount of terbinafine hydrochloride in biological fluids and wastewater samples using solid‐phase‐extraction based on magnetic nanoparticles followed by HPLC‐UV analysis

Abbasi

Faraji²,

Bahmaie

2014

Asia-Pacific J Chem Eng

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In this paper, the application of sodium dodecylsulfate-coated Fe 3 O 4 nanoparticles as an adsorbent was evaluated for the extraction and preconcentration of trace amounts of terbinafine hydrochloride in biological fluids before its determination by high-performance liquid chromatography with ultraviolet detection. Effects of various parameters on the extraction efficiency such as pH of solution, amount of sodium dodecylsulfate surfactant, extraction time, and desorption conditions were studied and optimized. Under the optimal conditions, the calibration curve was linear in the range of 2.5 to 500 μg L À1with the correlation coefficient of 0.9998. Moreover, the calibration graphs were linear in the range of 5 to 500 μg L À1 (seven standards)for both urine and plasma samples and the limits of detection were found to be 0.3, 0.7, and 1.5 μg L À1in aqueous, urine, and plasma samples, respectively. Also, the percent of relative standard deviation (RSD%) based on three replicate determinations was in the range of 0.9% to 6.8%. Finally, the proposed method was successfully applied for the extraction of terbinafine from real samples, and satisfactory results were obtained.

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Determination of terbinafine (Lamisil�) in human hair by microbore liquid chromatography/tandem mass spectrometry

Cited by 18 publications

References 19 publications

Evaluation of persistence of terbinafine in the hair of normal cats after 14 days of daily therapy

Evaluation of persistence of terbinafine in the hair of normal cats after 14 days of daily therapy

Determination of terbinafine in human plasma using UPLC–MS/MS: Application to a bioequivalence study in healthy subjects

Extracting trace amount of terbinafine hydrochloride in biological fluids and wastewater samples using solid‐phase‐extraction based on magnetic nanoparticles followed by HPLC‐UV analysis

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