Determination of the amount of simethicone in different drug formulations by the gravimetric method and comparison with the ftir method by chemometric methods

Guleli, Muge; İşsever, Sezin; Caliskan, Cem; Özbek, Mahmut

doi:10.5958/2231-5675.2021.00003.x

Asian Journal of Pharmaceutical Analysis

2021

DOI: 10.5958/2231-5675.2021.00003.x

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Determination of the amount of simethicone in different drug formulations by the gravimetric method and comparison with the ftir method by chemometric methods

Muge Guleli¹,

Sezin İşsever²,

Cem Caliskan³

et al.

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2024

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Infrared Fourier Transform Spectroscopy Method for Analysis of Valsartan and Amlodipine Besylate Combination

Bachri,

Husna

2024

RJPT

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This study investigates the analysis of the combination of Valsartan and Amlodipine besylate using the Infrared Fourier Transform and its quantitative calculations by chemometrics based on partial least squares with several variables. A calibration model has been formulated, and absorbance besylate measurements at wave numbers of 1634-1566 cm-1 for valsartan and 1127-1059 cm-1 for amlodipine every 2.0 cm-1. Then simultaneously determine valsartan and amlodipine combined in the tablet preparation. The Infrared Fourier Transform method used for Amlodipine besylate and Valsartan with calibration are y = 13.1317 X -0.0595 and y = 129,731 X - 0.026. The validation parameters is 0.9995, and 0.9999 for R2 values, RMSCEV is 0.02427 and 0.003189, and PRESS is 0.02121 and 0.0003662. Prediction ability was still acceptable and good for determination. The levels result were (101.52±2.74)% and (98.47±5.71)%, and valid with Relative Standard Deviation (RSD) respectively 2%, and average recovery percent obtained in range of 98-102%. The method identified provided guaranteed compliance with USP 43-NF 38 (2020).

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Infrared Fourier Transform Spectroscopy Method for Analysis of Valsartan and Amlodipine Besylate Combination

Bachri,

Husna

2024

RJPT

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Beyond the Spectrum: Exploring Unconventional Applications of Fourier Transform Infrared (FTIR) Spectroscopy

Therissa Mangam,

Narla,

Kumar Konda

et al. 2024

AJPA

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Fourier Transform Infrared (FTIR) spectroscopy, once primarily associated with structural analysis, has transcended its conventional role to become a versatile analytical powerhouse with applications spanning diverse fields. This review paper navigates the uncharted territories of FTIR's evolution, highlighting its innovative utilization in unconventional domains. Traditional applications of FTIR in structural analysis have expanded into captivating realms such as art conservation, nanotechnology, life sciences, and environmental monitoring. We delve into the transformation of FTIR into a tool for pigment identification in historical artworks, its role in probing nanoscale materials for composition analysis, and its emergence as a vital diagnostic tool in disease detection. Moreover, we explore how FTIR enables real-time air quality assessment, influencing urban environmental management. The synergy of FTIR with other techniques, the advancements in FTIR imaging, and its integration with bioinformatics contribute to the evolving landscape of applications. As FTIR continues to reshape the boundaries of knowledge and innovation, this paper serves as a tribute to its versatility, inspiring researchers to unlock new insights, collaborate across disciplines, and drive the progression of science.

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Determination of the amount of simethicone in different drug formulations by the gravimetric method and comparison with the ftir method by chemometric methods

Cited by 2 publications

References 0 publications

Infrared Fourier Transform Spectroscopy Method for Analysis of Valsartan and Amlodipine Besylate Combination

Infrared Fourier Transform Spectroscopy Method for Analysis of Valsartan and Amlodipine Besylate Combination

Beyond the Spectrum: Exploring Unconventional Applications of Fourier Transform Infrared (FTIR) Spectroscopy

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