Determination of the antimalaria drug artemether in pharmaceutical preparations by differential pulse polarography

Debnath, Chhanda; Haslinger, Ernst; Likussar, W.; Michelitsch, Astrid

doi:10.1016/j.jpba.2005.12.003

Cited by 12 publications

(8 citation statements)

References 30 publications

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“…23,24 In order to develop an analytical method for antimalarial endoperoxides, polarography is preferred because it is selective, well reproducible and durable. Furthermore it is not necessary to separate auxiliary materials with the result to be not time consuming and economical.…”

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confidence: 99%

Electrochemical Determination of Artemisinin in Artemisia annua L Herbal Tea Preparation and Optimization of Tea Making Approach

Debnath

Dobernig²,

Saha³

et al. 2011

Journal of the Korean Chemical Society

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ABSTRACT. Sometimes inhabitants in remote areas have inadequate or no access to modern medicines or medical services. They can get benefit in term of the treatment against malaria by cultivating selected breeding of A. annua and making teas or decoctions from the plant materials following the proper way of tea preparation. In order to have the maximum extraction efficiency for artemisinin, different ways of tea preparations of A. annua were investigated by applying the developed DPP method and described in this article. Tea was prepared by three different ways (cooking, without cooking with/without shaking and microwave oven) with different times. From the results, it has been found that higher concentration of artemisinin (84.7%) can be attained by following the approach for tea preparation without cooking with shaking for 15 minutes (R.S.D. 2.34%). The concentration of artemisinin decreases with cooking more than 1.5 min in microwave oven. The utmost extraction (88.9% of artemisinin) is possible to extract by shaking with boiled 5% ethanol in distilled water (R.S.D. 2.28%).

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confidence: 99%

Electrochemical Determination of Artemisinin in Artemisia annua L Herbal Tea Preparation and Optimization of Tea Making Approach

Debnath

Dobernig²,

Saha³

et al. 2011

Journal of the Korean Chemical Society

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“…Artesunate is a potent antimalarial drug. However, its poor bioavailability has resulted in its use in combination with selected antimalarials [29,57,58] . The combination of artesunate with some antimalarials has been reported as an effective approach to overcome drug resistance [59,60] .…”

Section: Resultsmentioning

confidence: 99%

Hybrid Compounds Containing a Ferrocene Scaffold as Potential Antimalarials

2021

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Malaria is an infectious disease, and it remains a serious health problem globally. The drugs developed for its treatment suffer from several shortcomings such as low water solubility, poor bioavailability, drug toxicity, and resistance. Molecular hybridization of different bioactive agents is a promising approach for developing hybrid compounds with improved therapeutic effects. Ferrocene, an organometallic, has been hybridized with several pharmacophores resulting in compounds with potent biological activities. In this research, a modified ferrocene scaffold was hybridized with selected pharmacophores. The synthesized compounds were characterized by Fourier‐Transform Infrared Spectroscopy (FTIR), Nuclear Magnetic Resonance Spectroscopy (NMR), and Liquid Chromatography‐Mass Spectroscopy. The hybrid compounds were obtained in good yields (53–76 %). In vitro evaluation against NF54 (drug‐sensitive) strain of Plasmodium falciparum parasites revealed the compounds, 16 and 19 (hybrids containing artesunate scaffold), together with 18 and 21 (hybrids containing oleanolic acid scaffold), as promising antimalarial agents. These compounds displayed IC50 values of 116.73±3.18, 56.33±15.20, 78.22±21.05, and 58.22±15.20 nM, respectively. These findings revealed the potency of ferrocene as a precursor for the development of promising antimalarials.

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“…The reaction between artemether and hydrochloric acid is shown in Fig. 2 and involves rearrangement of groups and the addition of a free carboxylate group [6][7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Optimizing derivatization conditions using an experimental design and simultaneous estimation of artemether and lumefantrine by ratio first order derivative spectrophotometric method

Christian¹,

Shah²,

Patel³

et al. 2017

Journal of Taibah University for Science

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Artemether-lumefantrine is the most widely used artemisinin-based combination therapy for malaria. The present work aims to develop and validate a simple, accurate, precise and rapid ratio first order derivative spectrophotometric method for the simultaneous estimation of artemether and lumefantrine in a fixed dose combination tablet. The first step in development of the method was to derivatize artemether. As artemether does not show absorption in the UV region, it was derivatized using hydrochloric acid as the derivatizing agent. The derivatizing conditions were further optimized by full factorial multivariate approach, where the independent variables were volume of concentrated hydrochloric acid and time taken for artemether derivatization at room temperature. Furthermore, based on the statistical analysis, derivatizing conditions were optimized i.e. 1.3 ml of conc. HCl at room temperature for 30 min. At this condition, the artemether was found to absorb in the UV region satisfactorily, and the absorbance of lumefantrine was found to remain unaffected. The developed method showed good calibration data in the range of 5-30 g/ml for artemether and 2-12 g/ml for lumefantrine. The mean % recovery values were found to be 99.96-100.49% and 99.48-100.31% for artemether and lumefantrine, respectively. Additionally, the developed method was effectively applied in the estimation of artemether and lumefantrine in a commercial tablet (ARH-L DS tablets), suggesting that it can be practically applied for quality control of routinely examined drugs in combined dosage forms with the reduced expenditure of time.

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Determination of the antimalaria drug artemether in pharmaceutical preparations by differential pulse polarography

Cited by 12 publications

References 30 publications

Electrochemical Determination of Artemisinin in Artemisia annua L Herbal Tea Preparation and Optimization of Tea Making Approach

Electrochemical Determination of Artemisinin in Artemisia annua L Herbal Tea Preparation and Optimization of Tea Making Approach

Hybrid Compounds Containing a Ferrocene Scaffold as Potential Antimalarials

Optimizing derivatization conditions using an experimental design and simultaneous estimation of artemether and lumefantrine by ratio first order derivative spectrophotometric method

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