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A hemin bulk modified carbon electrode with Adeps neutralis (solid fat) as binder was developed for the determination of antimalarial endoperoxide artemisinin in plant matrix. The hemin modified electrode showed significant catalytic activity for the electrochemical reduction of artemisinin at about À 380 mV vs. Ag/AgCl in phosphate buffer solution of pH 7 by using cyclic and differential pulse voltammetry. Under optimized conditions strict linearity between artemisinin concentration and height of the cathodic catalytic current peak was observed in 4.8 Â 10 À6 -7.8 Â 10 À5 M concentration range (R ¼ 0.9991) when using differential pulse voltammetry. The detection limit was calculated as 1.4 Â 10 À6 M of artemisinin. The developed electroanalytical device is suitable for the determination of artemisinin in Artemisia annua extracts.

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A cobalt phthalocyanine modified carbon paste electrode was constructed for the analysis of artemisinin in Artemisia annua plant. Artemisinin, a sesquiterpene endoperoxide, is a novel, important antimalarial drug and is used in the therapy against Plasmodium falciparum. The developed cobalt phthalocyanine modified electrode exhibited a significant electrocatalytic activity in presence of artemisinin when using cyclic and differential pulse voltammetry. Under optimized conditions in phosphate buffer of pH 7 a well defined voltammetric peak appeared at about À 500 mV vs. Ag/AgCl. The differential pulse voltammetric peak current of artemisinin was increased linearly with the concentration range of 2.1 Â 10 À5 to 5.3 Â 10 À4 M (R ¼ 0.9997). The limit of detection (LOD) was found to be 6.5 Â 10 À6 M. The modified electrode was successfully tested for detecting artemisinin in complex plant materials.