Determination of the cut-off value of serum alanine aminotransferase in patients undergoing hemodialysis, to identify biochemical activity in patients with hepatitis C viremia

Lopes, Edmundo Pessoa; Gouveia, Ericson Cavalcanti; Albuquerque, Ana Cecília Cavalcanti de; Sette, Luís Henrique Bezerra Cavalcanti; Mello, Luciano Albuquerque; Moreira, Regina Célia; Coêlho, Maria Rosângela Cunha Duarte

doi:10.1016/j.jcv.2005.09.010

Cited by 51 publications

(43 citation statements)

References 25 publications

(32 reference statements)

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“…3,4 Routine serologic controls performed biannually (including qualitative PCR technology) and testing at least every 2 mo for alanine aminotransferase (ALT) and ␥-glutamyl transpeptidase (␥-GTP) levels are important for monitoring viral hepatitis transmission within HD units. 5,6 When ALT values are Ͼ28 IU/L (upper normal limit for hemodialysis patients) [7][8][9] and/or ␥-GTP levels are increased (Ͼ43 IU/L), viral markers (hepatitis B surface antigen and DNA, anti-HCV, and HCV-RNA) and nonviral causes of liver disease (e.g., autoimmunity, toxic hepatitis, metabolic disorders) are studied to identify the cause of the elevated liver enzymes; however, the cause of liver disease cannot be established in approximately 2% of HD patients (personal observation).…”

mentioning

confidence: 99%

Occult Hepatitis C Virus Infection among Hemodialysis Patients

Barril

Castillo

Arenas

et al. 2008

Journal of the American Society of Nephrology

105

106

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mentioning

confidence: 99%

Occult Hepatitis C Virus Infection among Hemodialysis Patients

Barril

Castillo

Arenas

et al. 2008

Journal of the American Society of Nephrology

105

106

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“…On the ot her hand, nu me ro us stu di es con duc ted showed that its ac cu racy was higly va ri ab le. 3,4,[7][8][9][10][11][12][13][14][15][16][17][18] In our study, the only sig ni fi cant cor re la ti on was found bet we en se rum AST le vels and HAI in he pa ti tis C. On the ot her hand, in he pa ti tis B, serum AST le vels sho wed cor re la ti on both with fibro sis and HAI. Furt her mo re, a po si ti ve cor re la ti on was al so se en bet we en se rum ALT le vels and HAI in he pa ti tis B ca ses.…”

Section: Discussionmentioning

confidence: 53%

“…A sta tis ti cally sig ni fi - cant cor re la ti on was fo und bet we en bi oc he mi cal tests and his to lo gi cal fin dings in so me of the se studi es, tho ugh not in ot hers. [7][8][9][10][11][12][13][14][15][16][17][18] ALT is con si de red as a li ver-spe ci fic enz yme and nor mally fo und lar gely only in the li ver. Eleva ti ons in se rum ALT le vels are as so ci a ted with rever sib le or ir re ver sib le da ma ge to the he pa tocy te plas ma mem bra ne.…”

Section: Discussionmentioning

confidence: 99%

The Correlation of Serum Transaminase Values with Fibrosis Staging and Necroinflammatory Activity Scores in Chronic Hepatitis

Özkara¹,

Tosun²,

Sari³

et al. 2011

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The aim of this study is to compare the necroinflammatory activity score / histological activity index (HAI) and fibrosis score detected in liver biopsies with serum transaminase levels of chronic hepatitis B, C and steatohepatitis. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : This retrospective study included total of 398 cases whose liver biopsies were performed because increased liver enzyme levels and had the diagnoses of chronic hepatitis B, hepatitis C or steatohepatitis ofter liver biopsy between [2003][2004][2005][2006][2007]. The HAI and fibrosis scores of all cases were evaluated according to ISHAK classification criteria and then the results were compared with the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels at the time of biopsy. R Re es su ul lt ts s: : When all cases were considered, serum AST values emerged as the most statistically significant variable for hepatic fibrosis (r:0.311; p<0.01). Additionally, there was a correlation between AST values and HAI (r:0.295; p<0.01). On the other hand, serum ALT values did not correlate with (r:0.094; p>0.05) the extent of hepatic fibrosis but correlated weakly with HAI (r:0.242; p<0.01). C Co on nc cl lu us si io on n: : Serum AST level is found to be a significant indicator of histological activity index and fibrosis as well as hepatic damage. These findings suggested that, among other factors, serum AST values should be considered in decisions regarding the need for liver biopsy and treatment in patients with chronic hepatitis.K Ke ey y W Wo or rd ds s: : Aspartate aminotransferases; hepatitis, chronic; fibrosis Ö ÖZ ZE ET T A Am ma aç ç: : Bu çalışmanın amacı kronik hepatit B, hepatit C ve steatohepatitteki serum transaminaz düzeyleri ile karaciğer biyopsisinde tespit edilen nekroinflamatuvar aktivite derecesi / histolojik aktivite indeksi (HAİ) ve fibrozis skorunu karşılaştırmaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Bu retrospektif çalışmaya 2003-2007 yılları arasında kronik hepatit B, hepatit C veya yüksek karaciğer enzim seviyeleri nedeniyle karaciğer biyopsisi yapılıp steatohepatit tanısı alan toplam 398 olgu dahil edildi. Tüm olguların HAİ ve fibrozis skorları ISHAK sınıflama kriterlerine göre değerlendirildi ve ardından sonuçlar biyopsi anındaki serum alanin aminotransferaz (ALT) ve aspartat aminotransferaz (AST) düzeyleri ile karşılaştırıldı. B Bu ul lg gu ul la ar r: : Tüm olgular göz önüne alındığında, serum AST değerleri hepatik fibrozis için en anlamlı değişken olarak ortaya çıktı (r: 0.311; p <0.01). Ayrıca, AST değerleri ve HAI arasında da bir ilişki vardı (r: 0.295; p <0.01). Diğer taraftan, serum ALT değerleri ile hepatik fibrozisin derecesi arasında korelasyon olmamakla birlikte (r: 0.094; p> 0.05) HAI ile zayıf korelasyon saptandı (r: 0.242; p <0.01). S So on nu uç ç: : Serum AST düzeyinin histolojik aktivite indeksi, fibrozis ve aynı zamanda karaciğer hasarının önemli bir göstergesi olduğu saptamıştır. Bu bul...

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“…Mello Lde et al [23] , 2007 Lopes et al [24] , 2006 Albuquerque et al [25] , 2005 Carneiro et al [26] , 2001 China Maintain 7.01%-37.34% Ren et al [27] , 2011 Qi et al [28] , 2003 Greece 10%-29% Garinis et al [29] , 1999 Rigopoulou et al [30] , 2005 Sypsa et al [31] , 2005 Sweden 11.0% Almroth et al [32] , 2002 Iran 13.2% Alavian et al [33] , 2003 France 16.3% Salama et al [34] , 2000 Tunisia 19%-41.7% Bouzgarrou et al [35] , 2005 Ayed et al [36] , 2003 Libya 20.5% Daw et al [37] , 2002…”

Section: Risk Factorsmentioning

confidence: 99%

Management of hepatitis C virus infection in hemodialysis patients

Wang

et al. 2014

WJH

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currently the main treatment strategies for MHD patients with active HCV replication, but how to increase the sustained virological response and decrease the side effects is the key problem. IFNα-free treatments with two or three direct-acting antivirals without ribavirin in MHD patients are waiting for future investigations. Key words: Hemodialysis; Hepatitis C virus; Epidemiology; Risk factors; Prophylaxis; Treatment Core tip: The new hepatitis C virus (HCV) infections during maintenance hemodialysis (MHD) in recent years are mainly caused by the lack of stringent universal precautions. Strict implementation of universal precautions for HCV transmission has led to markedly decreased HCV infections in many hemodialysis units, but the anti-HCV negative HCV infection and occult HCV infection in MHD patients still should be noted. How to increase the sustained virological response and decrease the side effects is the key problem for the currently recommended interferon alpha-based antiviral therapy in MHD patients. Interferon alpha-free treatments with two or three direct-acting antivirals without ribavirin in MHD patients are waiting for future investigations.

show abstract

Determination of the cut-off value of serum alanine aminotransferase in patients undergoing hemodialysis, to identify biochemical activity in patients with hepatitis C viremia

Cited by 51 publications

References 25 publications

Occult Hepatitis C Virus Infection among Hemodialysis Patients

Occult Hepatitis C Virus Infection among Hemodialysis Patients

The Correlation of Serum Transaminase Values with Fibrosis Staging and Necroinflammatory Activity Scores in Chronic Hepatitis

Management of hepatitis C virus infection in hemodialysis patients

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