Determination of the estrogenic substance in blood serum by means of an estimation of the antiproteolytic power of the serum

Shute, Evan

doi:10.1016/s0002-9378(38)90380-1

Cited by 12 publications

(2 citation statements)

References 13 publications

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“…The oestradiol results d o not alter the conclusions of Shute (1938) who found clinically identical degrees of nausea and vomiting in patients with low, normal or high oestrogen values. It is likely that the pregnant woman can compensate for the gradual rise in oestrogens throughout early pregnancy but the sudden administration of a high-dose oestrogen pill as a postcoital contraceptive would cause a more profound metabolic upset and this could explain the resulting sickness.…”

Section: Discussionmentioning

confidence: 60%

Serum chorionic gonadotrophin (hCG), schwangerschaftsprotein 1(SP1), progesterone and oestradiol levels in patients with nausea and vomiting in early pregnancy

Masson¹,

Anthony²,

Chau³

1985

BJOG

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S e r u m concentrations of h u m a n chorionii gonadotrophin (hCG). schwangerschaftsprotein l(SPl), progesterone and oestradiol were measured in 1 16 pregnant w o m e n experiencing varying degrees o f nausea and vomiting or no nausea at all a t between 9 and 16 wceks gestation. 'Thc patients w e r e categorized into four groups, namcly asymptomatic. nausea alone, nausea a n d vomiting a n d hyperemesis gravidarum. T h e distribution of levels for each g r o u p were examined in relation t o t h e calculated normal ranges. Statistically higher hCG levels were f o u n d in out-patients with nausea alone or nausea and vomiting than in t h e asymptomatic women. No significant differences were found between t h e groups for any of t h e o t h c r measured variables, including t h e progesterone/oestradiol concentration ratio.Approximately one in two women will cxperience some nausea and vomiting in the early stages of pregnancy. commonly in the form of 'morning sickness' (Fairweather 1968). In a small proportion when the vomiting becomes more serious and persistent the term 'hyperemesis gravidarum' is applied.The aetiology of nausea and vomiting in pregnancy still remains obscure but endocrine, allergic and psychosomatic factors have all been suggested as responsible. This study was designed to consider four possible endocrine factors, two placental proteins, human chorionic gonadotrophin (hCG) and schwangerschaftsprotein 1 (SPl), and two steroid hormones, progesterone and oestradiol. although SPI and hCG might also be considered as possible allergens.Since its discovery hCG has been considered a likely candidate for causing nausea and vomiting in pregnancy becausc of the early and rapid rise in placental output, and Schoeneck (1942) found higher concentrations of hCG in the urinc of pregnant women who suffered from nausea and vomiting than in those who were asymptomatic. In a clinical study of patients with hyperemesis gravidarum Fairweather (1968) reported that the first trimester peak of hCG in urine and blood coincided with the most common gestation at admission, although Fairweather Rr Loraine (1962) had found that hCG excretion was significantly lower in patients with hyperemesis than in normal pregnant wornen. More recently, Soules ef crl. (1980) found no relation between absolute levels of hCG or 17-hydroxyprogesterone and the incidence or severity of naubea and vomiting in women with either normal or molar pregnancies.Maternal blood levels of SP1 have been shown to rise throughout pregnancy (Klopper 1979). but they have not been related to nausea and vomiting in early pregnancy.It has been suggestcd that nausea and vomiting are caused by progesterone deficiency, but 21 1

show abstract

Section: Discussionmentioning

confidence: 60%

Serum chorionic gonadotrophin (hCG), schwangerschaftsprotein 1(SP1), progesterone and oestradiol levels in patients with nausea and vomiting in early pregnancy

Masson¹,

Anthony²,

Chau³

1985

BJOG

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show abstract

“…This work lacks confirmation. In a series of articles Shute (1938) has produced strongly suggestive evidence that the antiproteolytic factor in the serum of aborting women is due to excess of estrogenic substance which in turn may develop on the basis of vitamin E deficiency. Treatment with vitamin E concentrates restored the normal proteolytic power of the serum and brought about therapeutic results.…”

Section: E Avitaminosesmentioning

confidence: 99%

Wheat Germ Oil in the Control of Fowl Paralysis

Jungherr¹

1940

Poultry Science

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Der Einfluss von Fructose auf den Chymotrypsininhibitor und auf die Eiweissfraktionen im Serum von Carcinomkranken

Leubner

1960

Klin Wochenschr

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Determination of the estrogenic substance in blood serum by means of an estimation of the antiproteolytic power of the serum

Cited by 12 publications

References 13 publications

Serum chorionic gonadotrophin (hCG), schwangerschaftsprotein 1(SP1), progesterone and oestradiol levels in patients with nausea and vomiting in early pregnancy

Serum chorionic gonadotrophin (hCG), schwangerschaftsprotein 1(SP1), progesterone and oestradiol levels in patients with nausea and vomiting in early pregnancy

Wheat Germ Oil in the Control of Fowl Paralysis

Der Einfluss von Fructose auf den Chymotrypsininhibitor und auf die Eiweissfraktionen im Serum von Carcinomkranken

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