Determination of the presence and pharmacokinetic profile of ciprofloxacin by TLC and HPLC method respectively in broiler chicken after single oral administration

Billah, Md. Mustahsan; Rana, S. M. Masud; Hossain, Mohammad Salim; Saifuddin, A. K. M.; Islam, Saiful; Naim, Zannatul; Barua, Santanu

doi:10.1038/ja.2014.56

Cited by 9 publications

(2 citation statements)

References 13 publications

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“…Because according to the literature, the ka parameter of a drug greatly affects the Tmax value of the drug, the smaller the KA value, the greater the Tmax value, and vice versa. The decrease in KA shows that the drug is absorbed slowly by the body, this is what causes a decrease in Tmax and Cmax quercetin in B test animals, besides that the increase in Cpmax can also be caused by the addition or homogeneous mixing of an active ingredient (Billah et al, 2014;Larochelle et al, 1982;Metwally et al, 1995;Stanczyk et al, 1983).…”

Section: Discussionmentioning

confidence: 99%

Quercetin Bioavailability Evaluation on Standardized Herbal Medicine Containing Guava Leaf Extract with HPLC

Yulion,

Yulianis,

Suntri

2023

BIOMEDNATPROCH

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Standardized herbal medicines are classified as one of Indonesia's natural medicine ingredients in addition to herbal medicine and phytopharmaceuticals. The safety and efficacy of standardized herbal medicines are scientifically proven through preclinical trials, and raw materials and products have been standardized. One includes standardized herbal medicines is diapet, psidii, lelap, fitolac, and glucogarp. To determine the bioavailability of standardized herbal products containing guava leaf extract (Psidium guajava L.). which uses single and combined natural materials. The method used is experimental with a crossover design. Blood samples are taken from the marginalis vein of the rabbit ear at 0.5 hours; 1; 2; 4; and 6. The level of quercetin in the blood is determined by the reverse-phase HPLC method. The mobile phase used is methanol:aquabidest (59:41,v/v), stationary phase octadecyl silica (C18), flow rate 1 mL/min, UV-Vis detector 370 nm, and injection volume 20 ?L. The value of bioavailability parameters obtained in the parameters Cpmax, Tmax, and AUC of product A is 1.486454 ?g / ml; 1.4 hours and 10.2615291 ?g/ml/h, product B is 1.29224019 ?g/ml; 1.5 hours and 11.30810501 ?g/ml/hour. Based on the results of this study, it can be concluded that the bioavailability profile of the two products is not much different, so it is expected that the effects caused are the same.

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Section: Discussionmentioning

confidence: 99%

Quercetin Bioavailability Evaluation on Standardized Herbal Medicine Containing Guava Leaf Extract with HPLC

Yulion,

Yulianis,

Suntri

2023

BIOMEDNATPROCH

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“…Therefore, a sensitive, e cient method must be developed to detect the concentration of CIP in environmental water. At present, common detection methods include high-performance liquid chromatography (Mirzajani and Keshavarz, 2019;Billah et al, 2014) Although these methods provide sensitive, e cient detection of CIP, they have some disadvantages over uorescence analyses. For example, a large detection time, large sample pretreatment time, and high instrument cost are not conducive to large-scale popularization.…”

Section: Introductionmentioning

confidence: 99%

Construction of carbon quantum dots/riboflavin fluorescent probe and its application in the detection of ciprofloxacin

Lan

Bao

et al. 2023

Preprint

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This paper synthesized blue-fluorescent carbon quantum dots (b-CQDs) using a hydrothermal method, in which passionfruit shells is used as the carbon source and diethylenetriamine is used as the nitrogen source. The average particle size of the b-CQDs is 3.29 nm, and the quantum yield is 19.6%. Riboflavin was added to the CQDs to form a fluorescent probe with double emission peaks at 445 and 510 nm, belonging to b-CQDs and riboflavin, respectively. Their physical structure and optical properties were investigated by a series of characterizations. The results show that b-CQDs have good fluorescence stability. An experimental analysis showed that the addition of ciprofloxacin (CIP) to the fluorescent probe can significantly enhance the emission peak at 445 nm, whereas the emission peak at 510 nm remains unchanged. Accordingly, we constructed a ratio fluorescence method using b-CQDs/riboflavin as the fluorescent probe to detect CIP. In the water system, the I445 nm/I510 nm ratio of the fluorescent probe has an obvious linear relationship with CIP at a concentration of 0–250 µmol·L− 1. The linear equation obtained by fitting is I445 nm/I510 nm = 0.0028CCIP + 1.1510, where the correlation coefficient R2 is 0.9961 and the detection limit is 0.86 µmol·L− 1.

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Construction of carbon quantum dots/riboflavin fluorescent probe and its application in the detection of ciprofloxacin

Fu,

Lan,

Bao

et al. 2024

Luminescence

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The research outlined a novel approach for creating a sensitive and efficient ratio fluorescent probe for ciprofloxacin (CIP) detection. The method used the biomass materials passionfruit shell and diethylenetriamine as carbon and nitrogen sources, respectively, to prepare blue fluorescent carbon quantum dots (b‐CQDs) with an average size of 3.29 nm and a quantum yield of 19.6% by a hydrothermal method. The newly designed b‐CQDs/riboflavin ratio fluorescent probe demonstrates a distinct advantage for CIP monitoring, exhibiting a marked increase in fluorescence intensity at 445 nm upon interaction with CIP, while maintaining a stable intensity at 510 nm. In the water system, the I445 nm/I510 nm ratio of the fluorescent probe showed a significant linear relationship with CIP at the concentrations of 0–250 μmol·L−1, and the probe boasts a low detection limit of 0.86 μmol·L−1. The outstanding selectivity, broad detection range, low detection limits, and high quantum yield of the b‐CQDs highlight their significant potential in the development of advanced sensing probes for efficient detection of ciprofloxacin, offering promising insights for future sensor technology advancements.

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Determination of the presence and pharmacokinetic profile of ciprofloxacin by TLC and HPLC method respectively in broiler chicken after single oral administration

Cited by 9 publications

References 13 publications

Quercetin Bioavailability Evaluation on Standardized Herbal Medicine Containing Guava Leaf Extract with HPLC

Quercetin Bioavailability Evaluation on Standardized Herbal Medicine Containing Guava Leaf Extract with HPLC

Construction of carbon quantum dots/riboflavin fluorescent probe and its application in the detection of ciprofloxacin

Construction of carbon quantum dots/riboflavin fluorescent probe and its application in the detection of ciprofloxacin

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