Determination of the Stabilization Time of the Solution-Air Interface for Aggregates Formed by NaC in Mixtures with SDS and PEO, Investigated by Dynamic Surface Tension Measurements

Albendazole (ABZ) and ricobendazole (RBZ) are referred to as class II compounds in the Biopharmaceutical Classification System. These drugs exhibit poor solubility, which profoundly affects their oral bioavailability. Micellar systems are excellent pharmaceutical tools to enhance solubilization and absorption of poorly soluble compounds. Polysorbate 80 (P80), poloxamer 407 (P407), sodium cholate (Na-C), and sodium deoxycholate (Na-DC) have been selected as surfactants to study the solubilization process of these drugs. Fluorescence emission was applied in order to obtain surfactant/fluorophore (S/F) ratio, critical micellar concentration, protection efficiency of micelles, and thermodynamic parameters. Systems were characterized by their size and zeta potential. A blue shift from 350 to 345 nm was observed when ABZ was included in P80, Na-DC, and Na-C micelles, while RBZ showed a slight change in the fluorescence band. P80 showed a significant solubilization capacity: S/F values were 688 for ABZ at pH 4 and 656 for RBZ at pH 6. Additionally, P80 micellar systems presented the smallest size (10 nm) and their size was not affected by pH change. S/F ratio for bile salts was tenfold higher than for the other surfactants. Quenching plots were linear and their constant values (2.17/M for ABZ and 2.29/M for RBZ) decreased with the addition of the surfactants, indicating a protective effect of the micelles. Na-DC showed better protective efficacy for ABZ and RBZ than the other surfactants (constant values 0.54 and 1.57/M, respectively), showing the drug inclusion into the micelles. Entropic parameters were negative in agreement with micelle formation.

show abstract

Dynamic Surface Properties of Eco-Friendly Cationic Saccharide Surfactants at the Water/Air Interface

Liu¹,

Li²,

Wang³

et al. 2019

Tenside Surfactants Detergents

View full text Add to dashboard Cite

The equilibrium surface properties and dynamic surface tension (DST) are presented for aqueous solutions of novel eco-friendly cationic saccharide surfactants (CnDGPB) at different concentrations and temperatures. The equilibrium surface tension, the DST, the effective diffusion coefficients and the activation barrier of the surfactants are calculated and analyzed. In addition, the general diffusion mechanism of the surfactants is proposed. The equilibrium surface tension results show that the γCMC and CMC values decrease with increasing temperature. The interactions (repulsion forces) between the hydrophobic groups and water molecules decrease with increasing temperature, which results in increased HLB values. This phenomenon causes a higher Amin and lower Γmax. The DST of CnDGPB below and above the CMC is tested by the maximum bubble pressure method at temperature from 25 °C to 45 °C. The adsorption activation energy of CnDGPB is between 3 kJ/mol and 20 kJ/mol. The results show that the final stages of the DST decays are consistent with the activated diffusion-controlled adsorption mechanism.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Determination of the Stabilization Time of the Solution-Air Interface for Aggregates Formed by NaC in Mixtures with SDS and PEO, Investigated by Dynamic Surface Tension Measurements

Cited by 3 publications

References 32 publications

Physicochemical and spectral evaluation of the interactional behavior of nicotinic acid (vitamin B₃) with mixed [sodium deoxycholate (bile salt) + cetyltrimethylammonium bromide] surfactants

Physicochemical and spectral evaluation of the interactional behavior of nicotinic acid (vitamin B₃) with mixed [sodium deoxycholate (bile salt) + cetyltrimethylammonium bromide] surfactants

Application of Fluorescence Emission for Characterization of Albendazole and Ricobendazole Micellar Systems: Elucidation of the Molecular Mechanism of Drug Solubilization Process

Dynamic Surface Properties of Eco-Friendly Cationic Saccharide Surfactants at the Water/Air Interface

Contact Info

Product

Resources

About

Determination of the Stabilization Time of the Solution-Air Interface for Aggregates Formed by NaC in Mixtures with SDS and PEO, Investigated by Dynamic Surface Tension Measurements

Cited by 3 publications

References 32 publications

Physicochemical and spectral evaluation of the interactional behavior of nicotinic acid (vitamin B3) with mixed [sodium deoxycholate (bile salt) + cetyltrimethylammonium bromide] surfactants

Physicochemical and spectral evaluation of the interactional behavior of nicotinic acid (vitamin B3) with mixed [sodium deoxycholate (bile salt) + cetyltrimethylammonium bromide] surfactants

Application of Fluorescence Emission for Characterization of Albendazole and Ricobendazole Micellar Systems: Elucidation of the Molecular Mechanism of Drug Solubilization Process

Dynamic Surface Properties of Eco-Friendly Cationic Saccharide Surfactants at the Water/Air Interface

Contact Info

Product

Resources

About

Physicochemical and spectral evaluation of the interactional behavior of nicotinic acid (vitamin B₃) with mixed [sodium deoxycholate (bile salt) + cetyltrimethylammonium bromide] surfactants

Physicochemical and spectral evaluation of the interactional behavior of nicotinic acid (vitamin B₃) with mixed [sodium deoxycholate (bile salt) + cetyltrimethylammonium bromide] surfactants