This paper presents a study and proposes a new methodology to analyze, evaluate and reduce the overall uncertainty of instrumentations for EMC measurements. For the scope of this work, the front end of a commercial EMI receiver is chosen and variations due to tolerances, temperature and frequency response of the system are evaluated. This paper illustrates in detail how to treat each block composing the model by analyzing each discrete component, and how to evaluate their influence on the measurand. Since a model can have hundreds or even thousands of parameters, the probability distribution functions (PDFs) of some variable might be unknown. So, a method that allows to obtain in a fast and easy way the uncertainty of the measurement despite having so many variables, to then being able to evaluate the influence of each component on the measurand, is necessary for a correct design. In this way, it will be possible to indicate which discrete components have the most influence on the measurand and thus set the maximum tolerances allowed and being able to design a cost-effective solution. Furthermore, this works presents a methodology which can easily be extended and applied to estimate and compute the uncertainty for electromagnetic interferences, energy storage systems (ESS), energy production, electric machines, electric transports and power plants in general.