Determination of Tissue Thermal Conductivity by Measuring and Modeling Temperature Rise Induced in Tissue by Pulsed Focused Ultrasound

Kujawska, T.; Secomski, Wojciech; Kruglenko, Eleonora; Krawczyk, Kazimierz; Nowicki, Andrzej

doi:10.1371/journal.pone.0094929

Cited by 24 publications

(19 citation statements)

References 10 publications

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“…For each fixed frequency of ultrasound in the considered spectral range (3)(4)(5)(6)(7)(8), the mean attenuation values revealed for MNP8 and MNP16 were significantly different from the attenuation values for MMP8 and MMP16, respectively. More specifically, testing the difference between the average attenuation measured in MNP8 and MMP8 yielded a P<0.001 for all frequencies considered.…”

Section: E Statistical Analysis Resultsmentioning

confidence: 76%

“…Comparing samples of MNP16 and MMP16, P < 0.001 and P < 0.05 were obtained for the 3.5-8 and 3-3.49 MHz frequency bands, respectively. The two-sample test was also applied to the mean BSC values determined for each fixed ultrasonic frequency in the considered spectral range (3)(4)(5)(6)(7)(8). The results provided that the materials of the MNP8 and MNP16 samples differed statistically significantly from the corresponding materials of the MMP8 and MMP16 samples (P < 0.001).…”

Section: E Statistical Analysis Resultsmentioning

confidence: 99%

“…It is particularly important that thermal therapy does not destroy the neighboring healthy surroundings. Therefore, the heating techniques must be carefully tested . Phantom materials dedicated for testing must meet the requirements of ultrasonic heating efficiency.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the heating techniques must be carefully tested. 4,5 Phantom materials dedicated for testing must meet the requirements of ultrasonic heating efficiency. These materials should attenuate the ultrasound and the main part of the energy lost should be converted into thermal energy, as it is in the tissue.…”

Section: Introductionmentioning

confidence: 99%

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Ultrasound assessment of the conversion of sound energy into heat in tissue phantoms enriched with magnetic micro‐ and nanoparticles

et al. 2019

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Purpose Nowadays, the improvement of ultrasonic hyperthermia therapy is often achieved by adding hard particles to the sonicated medium in order to increase the heating efficiency. The explanation of the phenomenon of ultrasonic heating still requires testing on tissue mimicking materials (TMMs), enriched with particles of different sizes and physical properties. Our goal was to determine, by comparing their quantitative acoustic properties, which TMMs, with magnetic micro‐ or nanoparticles, convert more ultrasonic energy into heat or which of the particles embedded in the agar gel act as more effective thermal sonosensitizers. Methods We manufactured a pure agar gel and an agar gel with the addition of magnetic micro‐ or nanoparticles in two proportions of 8 and 16 mg/ml. Ultrasound quantitative techniques, the broadband reflection substitution technique and backscattered spectrum analysis were used to characterize the samples by speed of sound (SOS), frequency‐dependent attenuation, and backscattering coefficients. The integrated backscattering coefficients were also calculated. The quantitative parameters, scattering, and attenuation coefficients of ultrasound in phantoms with micro‐ and nanoparticles were estimated. Based on the attenuation and scattering of ultrasound in the samples, the ultrasonic energy absorption, which determines the heating efficiency, was evaluated. Additionally, the temperature increase during sonication of the phantoms by an ultrasonic beam was directly measured using thermocouples. Results The density of the materials with nanoparticles was higher than for the materials with microparticles with the same fractions of particles. The SOS for all materials ranged from 1489 to 1499 m/s. The attenuation in the whole frequency range (3–8 MHz) was higher for the materials with nanoparticles than for the materials with microparticles. For the materials with the lower content (8 mg/ml) of particles, the attenuation coefficient was 0.2 dB/(MHz cm). For the 16 mg/ml concentration of nanoparticles and microparticles, the attenuation coefficients were 0.66 and 0.45 dB/(MHz cm), respectively. The value of backscattering coefficient in the whole frequency range was greater for the materials with microparticles than for the materials with nanoparticles. The values of the integrated backscattering coefficient were 0.05 and 0.08 1/m for the materials with nanoparticles and 0.46 and 0.82 1/m for the materials with microparticles and concentrations of 8 and 16 mg/ml, respectively. The rates of temperature increase in the first 3 s due to ultrasonic heating were higher for the materials with nanoparticles than for the materials with microparticles. Conclusions Based on acoustical measurements, we confirmed that all materials can be used as tissue phantoms in the study of ultrasonic hyperthermia, as their properties were in the range of soft tissue properties. We found that the nanoparticle‐doped materials had greater attenuation and smaller scattering of ultrasound than the materials with microparticles,...

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Section: E Statistical Analysis Resultsmentioning

confidence: 76%

Section: E Statistical Analysis Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ultrasound assessment of the conversion of sound energy into heat in tissue phantoms enriched with magnetic micro‐ and nanoparticles

et al. 2019

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“…With rapid advancement in modern bioscience and medicine, research on biological heat transport has received major attention over the years 1 2 3 4 5 6 7 8 9 . It is well accepted in modern medicine that temperature history and cooling/warming rates experienced by biomaterials during exothermic/endothermic procedures greatly affect the biological outcome.…”

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confidence: 99%

High accuracy thermal conductivity measurement of aqueous cryoprotective agents and semi-rigid biological tissues using a microfabricated thermal sensor

Liang

Sekar

Zhao

et al. 2015

Sci Rep

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An improved thermal-needle approach for accurate and fast measurement of thermal conductivity of aqueous and soft biomaterials was developed using microfabricated thermal conductivity sensors. This microscopic measuring device was comprehensively characterized at temperatures from 0 °C to 40 °C. Despite the previous belief, system calibration constant was observed to be highly temperature-dependent. Dynamic thermal conductivity response during cooling (40 °C to –40 °C) was observed using the miniaturized single tip sensor for various concentrations of CPAs, i.e., glycerol, ethylene glycol and dimethyl sulfoxide. Chicken breast, chicken skin, porcine limb, and bovine liver were assayed to investigate the effect of anatomical heterogeneity on thermal conductivity using the arrayed multi-tip sensor at 20 °C. Experimental results revealed distinctive differences in localized thermal conductivity, which suggests the use of approximated or constant property values is expected to bring about results with largely inflated uncertainties when investigating bio-heat transfer mechanisms and/or performing sophisticated thermal modeling with complex biological tissues. Overall, the presented micro thermal sensor with automated data analysis algorithm is a promising approach for direct thermal conductivity measurement of aqueous solutions and soft biomaterials and is of great value to cryopreservation of tissues, hyperthermia or cryogenic, and other thermal-based clinical diagnostics and treatments.

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Protein Characterization by Thermal Property Measurement

Seenivasan

Panda

2017

Glass Transition and Phase Transitions in Food and Biological Materials

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Determination of Tissue Thermal Conductivity by Measuring and Modeling Temperature Rise Induced in Tissue by Pulsed Focused Ultrasound

Cited by 24 publications

References 10 publications

Ultrasound assessment of the conversion of sound energy into heat in tissue phantoms enriched with magnetic micro‐ and nanoparticles

Ultrasound assessment of the conversion of sound energy into heat in tissue phantoms enriched with magnetic micro‐ and nanoparticles

High accuracy thermal conductivity measurement of aqueous cryoprotective agents and semi-rigid biological tissues using a microfabricated thermal sensor

Protein Characterization by Thermal Property Measurement

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