Determination of total blood volume by indicator dilution: a comparison of mean transit time and mass conservation principle

Picker, O.; Wietasch, G.; Scheeren, Thomas; Arndt, JO

doi:10.1007/s001340100901

Cited by 21 publications

(12 citation statements)

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“…Since the ICG is continuously being eliminated by the liver, it is necessary to identify from the clearance curve the point in time when the ICG is fully mixed with blood but not yet eliminated by the liver. It has previously been suggested when using arterial ICG monitoring that a line can be backextrapolated from the exponentially decaying part of the clearance curve to either the time of injection or the mean transit time (21,22) and the corresponding ICG concentration is regarded as the initial fully circulated ICG concentration, i.e. C 0 ICG,bl .…”

mentioning

confidence: 99%

A New Method for the Measurement of Cerebral Blood Volume and Total Circulating Blood Volume Using Near Infrared Spatially Resolved Spectroscopy and Indocyanine Green: Application and Validation in Neonates

et al. 2004

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A new technique known as tissue dye densitometry (TDD) has been developed to simultaneously measure cerebral blood volume (CBV) and total circulating blood volume (TCV) using near infrared (NIR) spatially resolved spectroscopy (SRS) and the injection of indocyanine green (ICG). Using a medical NIR spectrometer with SRS capability (NIRO-300, Hamamatsu KK), a new parameter is calculated known as the ICG Hb index (IHI), which represents the ratio of ICG concentration to Hb concentration in tissue. Acting as a tracer, ICG is cleared by the liver over 15 min, providing a change of tracer concentration (⌬C ICG ,tis), which allows the calculation of the total Hb concentration in tissue (tcHb) using the equation: tcHb tis ( molar) ϭ ⌬C ICG,tis / ⌬IHI. The CBV can subsequently be calculated from tcHb tis given the absolute Hb concentration in blood (g/dL), from which the ICG concentration in blood (⌬C ICG,bl ) is obtained. By backextrapolating the ⌬C ICG,bl curve to the peak time, the initial ICG concentration in tissue blood (C 0 ICG,bl ) can be found and TCV can then be calculated. The TCV of 17 neonates were measured using the TDD technique and for comparison using the previously reported fetal Hb dilution technique (FHD Achieving a stable circulation in the first hours of life is fundamental to the provision of successful neonatal intensive care. Many clinical studies describe the administration of boluses of fluid to expand the total circulating volume (TCV) in response to clinical signs of poor skin perfusion, hypotension or acidosis and yet studies both in adults and the newborn show the prediction of hypovolemia by clinical assessment to be poor (1, 2). The availability of a simple cotside method to estimate TCV that could be used shortly after birth would be a useful tool both for the neonatal clinician and the researcher. Methods used previously involving the injection of autologous red cells labeled with biotin (3) or repeated blood sampling following injection of a marker such as indocyanine green (4)

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confidence: 99%

A New Method for the Measurement of Cerebral Blood Volume and Total Circulating Blood Volume Using Near Infrared Spatially Resolved Spectroscopy and Indocyanine Green: Application and Validation in Neonates

et al. 2004

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“…The MTT parameter depends to a large extent on the tail end of the transit time distribution and less on the location of the peak of the highly skewed transit time distribution. The high degree of distribution skewness is well recognized in cardiovascular research in dye dilution curves used in blood flow measurements (Fonseca-Costa & Zin 1979; von Spiegeland & Hoeft 1998; Picker et al 2001). …”

Section: Resultsmentioning

confidence: 99%

Pharmacokinetic differentiation of drug candidates using system analysis and physiological-based modelling. Comparison of C.E.R.A. and erythropoietin

et al. 2008

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Evaluation of the pharmacokinetics (PKs) in a proper physiological context is paramount to elucidate the factors that may improve a drug's PK properties. Using modern system analysis-based physiological modelling principles, this work applies a novel kinetic analysis framework to a PK comparison of two erythropoietically active drugs, C.E.R.A. (continuous erythropoietin receptor activator) and recombinant human erythropoietin (Epo), aimed at elucidating the main factors responsible for the substantial PK differences seen. The evaluation according to the new model is compared with a compartmental model analysis. Sheep (n = 7 for Epo; n = 8 for C.E.R.A.) received intravenous bolus injections of Epo and C.E.R.A. Baseline and 20-30 blood samples per injection were assayed by radioimmunoassay. Fundamental physiologically based PK building block principles were introduced, proceeding to the construction of a general PK model and several submodels from which a final PK model was selected based on information theoretical principles. The compartmental comparison analysis use a two-compartment model with central Michaelis-Menten elimination. Several lines of evidence support the hypothesis that the desirable slow elimination of C.E.R.A. relative to Epo is mainly caused by a smaller recirculation extraction fraction, which appears more influential on the elimination kinetics than the mean circulation transit time. The compartmental analysis demonstrates large differences in several PK parameters that contribute to C.E.R.A.'s slower elimination, consistent with the recirculation model analysis. It is hypothesized that C.E.R.A.'s smaller recirculatory extraction fraction is due to a reduced receptor-mediated elimination, consistent with in-vitro measurements where C.E.R.A. shows Epo-receptor binding with a lower association constant and a larger dissociation constant.

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“…The anaesthetised dogs were allowed to breathe spontaneously. Blood volumes were measured using the dye dilution technique: PBV was measured as the volume of blood between the pulmonary and aortic valve, and Vd circ by two-compartmental curve fitting [1,2]. The PBV/Vd circ ratio was used as a measure of blood volume distribution.…”

Section: Methodsmentioning

confidence: 99%

Do intravascular hypovolaemia and hypervolaemia result in changes in pulmonary blood volume?

et al. 2015

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Determination of total blood volume by indicator dilution: a comparison of mean transit time and mass conservation principle

Cited by 21 publications

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A New Method for the Measurement of Cerebral Blood Volume and Total Circulating Blood Volume Using Near Infrared Spatially Resolved Spectroscopy and Indocyanine Green: Application and Validation in Neonates

A New Method for the Measurement of Cerebral Blood Volume and Total Circulating Blood Volume Using Near Infrared Spatially Resolved Spectroscopy and Indocyanine Green: Application and Validation in Neonates

Pharmacokinetic differentiation of drug candidates using system analysis and physiological-based modelling. Comparison of C.E.R.A. and erythropoietin

Do intravascular hypovolaemia and hypervolaemia result in changes in pulmonary blood volume?

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