Determination of total maleic acid, fumaric acid, p-hydroxybenzoic acid and benzoic acid in food by ultra performance liquid chromatography-tandem mass spectrometry

Chen, Yi-Guang; Luo, Haoming; Guo, Xiao‐Na; Xian, Yuezhong; Luo, Da; Wu, Yuluan

doi:10.1039/c4ay00489b

Cited by 10 publications

(6 citation statements)

References 32 publications

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“…Because of effective power in qualication and quantication, chromatographic methods such as gas chromatography (GC), 8,9 high-performance liquid chromatography (HPLC) 10,11 and capillary electrophoresis 12 are the most popular techniques for the analysis of phenolic acids. However, owing to the complexity of food matrices, low concentration and high water solubility of phenolic acids, to enrich the target analytes and clean up the sample matrices, a suitable sample pretreatment technique is necessary before the chromatographic analysis.…”

Section: Introductionmentioning

confidence: 99%

Determination of trace phenolic acids in fruit juice samples using multiple monolithic fiber solid-phase microextraction coupled with high-performance liquid chromatography

Pei

Huang

2016

Anal. Methods

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Section: Introductionmentioning

confidence: 99%

Determination of trace phenolic acids in fruit juice samples using multiple monolithic fiber solid-phase microextraction coupled with high-performance liquid chromatography

Pei

Huang

2016

Anal. Methods

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“…The auto sampler was conditioned at 25°C, the injection volume was 2 μl, and the flow rate was 0.3 ml•min -1 . The raw data were detected by a UPLC-diode array detector (DAD) at 254 nm [19]. The binary gradient elution system consisted of solvent A (0.25% formic acid water) and solvent B (methanol).…”

Section: Uplc Analytical Methodsmentioning

confidence: 99%

Isolation of a Pseudomonas putida strain that degrades p-hydroxybenzoic acid from the soil of a Panax ginseng field

Shen

Zhu

Guo

et al. 2020

Preprint

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Background: Panax ginseng is a valuable herbal medicine which has been applied in eastern Asia to maintain their physical vitality for millennia. However, continuous cropping leads to the accumulation of allelochemicals, which subsequently reduces the quality and yield of P. ginseng, and arable soils for P. ginseng cultivation are getting scarce. Methods: In this study, a strain highly efficient degrading p-hydroxybenzoic acid was isolated from the rhizosphere soil of a ginseng cultivation field. Subsequently, its draft genome was sequenced, and the key genes involving the p-hydroxybenzoic acid-degrading pathway were identified by bioinformatics software. Results: Based on its biophysical/biochemical characteristics, analysis of the 16S rRNA sequence and gyrB gene authentication, strain LD6 was identified as Pseudomonas putida LD6. The initial p-hydroxybenzoic acid concentration in minimal salt medium was 100 mg•L-1, and after 8 d of bacterial culture in the laboratory, the degraded reached 97.35%. The p-hydroxybenzoic acid content was decreased by 35.21%, and the ginseng death rate was decreased by 38.46% in the rhizosphere soil of P. ginseng inoculated with strain LD6. The draft genome sequence consisted of 5,765,634 bp, and the genome comprised 5186 protein-coding genes, and the pobA, catB, pcaG, UbiA, and UbiX genes were annotated, and may play important roles in p-hydroxybenzoic acid degradation.Conclusion: Isolation and manipulation of functional bacteria is an effective strategy to alleviate ginseng continuous cropping problems and enhance the quality and yield of P. ginseng.

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“…The six compounds have been individually determined by liquid chromatography–tandem mass spectrometric methods (An, Wu, & Wei, ; Chen, Luo, & Guo, ; Moradi‐Afrapoli, Oufir, & Walter, ; Nie, Li, & Peng, ; Qiu, Zhao, & Hao, ; Rui, Lei, & Zhang, ). However, previous studies have only simultaneously determined only two or three.…”

Section: Introductionmentioning

confidence: 99%

“…Thesixcompoundshavebeenindividuallydeterminedbyliquidchromatography-tandem mass spectrometric methods (An, Wu, & Wei, 2009;Chen, Luo, & Guo, 2014;Moradi-Afrapoli, Oufir, & Walter, 2016;Nie,Li,&Peng,2012;Qiu,Zhao,&Hao,2016;Rui,Lei,&Zhang,2010).However, previous studies have only simultaneously determined only two or three. Moreover, some low-concentration compounds in MGZKTs, such askaempferolandquercetin,cannotbedetectedusingthesemethods;they are notsensitiveand efficientenoughfor pharmacokineticstudyowingto the limit of detection and sample preparation methods.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of kaempferol, quercetin, mangiferin, gallic acid, p‐hydroxybenzoic acid and chlorpheniramine maleate in rat plasma after oral administration of Mang‐Guo‐Zhi‐Ke tablets by UHPLC‐MS/MS and its application to pharmacokinetics

Deng

Qian

et al. 2017

Biomedical Chromatography

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Mang-Guo-Zhi-Ke tablets (MGZKTs) is an effective Chinese patent medicine. It contains mango leaf extract as the main raw material and the antihistamine drug, chlorpheniramine maleate is included in the formulation. However, its pharmacokinetic effect is rarely reported. A highly sensitive, reliable and rapid high-throughput method using ultra-high-performance liquid chromatography with tandem mass spectrometry (UHPLC-MS/MS) was used to simultaneously determine kaempferol, quercetin, mangiferin, p-hydroxybenzoic acid, gallic acid and chlorpheniramine maleate in rat plasma after oral administration of MGZKTs. The method was successfully developed and fully validated to investigate the pharmacokinetics of MGZKTs. Chloramphenicol and clarithromycin were used as internal standards (IS). A practicable protein precipitation procedure with methanol was adopted for sample preparation. The samples were separated on an Acquity UHPLC Syncronis C column (100 × 2.1 mm, 1.7 μm) using 0.1% formic acid-acetonitrile as the mobile phase. The flow rate was set at 0.4 mL/min. The obtained calibration curves were linear in the concentration range of ~1-1000 ng/mL for plasma (r > 0.99). Method validation results met the criteria reported in the US Food and Drug Administration guidelines. Quercetin, p-hydroxybenzoic acid and kaempferol were absorbed rapidly and reached the peak concentration between 0.16 and 0.25 h. This validated that the UHPLC-MS/MS method was successfully applied to study the pharmacokinetic parameters of the six compounds in rat plasma after oral administration of MGZKTs. This evidence will be useful for the clinical rational use of Mang-Guo-Zhi-Ke tablets.

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Determination of total maleic acid, fumaric acid, p-hydroxybenzoic acid and benzoic acid in food by ultra performance liquid chromatography-tandem mass spectrometry

Abstract: Hydrolysis reaction coupling to UPLC-MS/MS was employed for the determination of the total content of four organic acids in food.

Cited by 10 publications

References 32 publications

Determination of trace phenolic acids in fruit juice samples using multiple monolithic fiber solid-phase microextraction coupled with high-performance liquid chromatography

Determination of trace phenolic acids in fruit juice samples using multiple monolithic fiber solid-phase microextraction coupled with high-performance liquid chromatography

Isolation of a Pseudomonas putida strain that degrades p-hydroxybenzoic acid from the soil of a Panax ginseng field

Simultaneous determination of kaempferol, quercetin, mangiferin, gallic acid, p‐hydroxybenzoic acid and chlorpheniramine maleate in rat plasma after oral administration of Mang‐Guo‐Zhi‐Ke tablets by UHPLC‐MS/MS and its application to pharmacokinetics

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