Safety study of herbal drugs and food item is now mandatory as per WHO guidelines, to prevent the toxicity due to the material found in the soil and the environment. It includes determination of aflatoxin, heavy metal, pesticidal residue, microbial load. Therefore, the present study was aimed to evaluate safety parameter in Sehjana (Moringa oleifera Lam) Fruits powder, a very common drug used in Unani and Ayurvedic system of medicine for its cardiac and circulatory stimulant, and anti-oxidant, anti-inflammatory effect used in acute rheumatism, Asthma, gout, paralysis. Study reveals the presence of microbial loads, and heavy metals, lead, cadmium, mercury, and arsenic within permissible limit as per WHO guidelines, while aflatoxins, pesticides was found to be absent in the crude drug sample, indicating that the drug is free from toxicity.