Determination of urinary oxidative DNA damage marker 8-hydroxy-2′-deoxyguanosine and the association with cigarette smoking

Yao, Qinghong; Mei, Surong; Weng, Qianfeng; Zhang, Pu-Duen; Yang, Qing; Wu, Caiying; Xu, Guowang

doi:10.1016/j.talanta.2003.12.024

Cited by 51 publications

(28 citation statements)

References 39 publications

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“…This is in agreement with numerous previous reports studied in smokers 11,12) or bus depot workers, who were exposed to respirable particles and pollutants 27) ; however, our cross-sectional study can add new information by showing a significant association between the urinary 8-OHdG level and the CAVI as an indicator of arteriosclerosis in hypertensive patients. As CAVI has been demonstrated to be high in smoking subjects 24) , the smoking status also differed in the comparison between groups with normal and elevated CAVI in the present study (Table 4); therefore, we examined the relationship between urinary 8-OHdG and CAVI in 87 non-smokers in the present study.…”

Section: Association Between Cavi and Other Variablessupporting

confidence: 93%

“…where Ps and Pd are systolic and diastolic blood pressure, PWV is pulse wave velocity from the origin damaged by oxidative stress and repaired, the 8-OHdG produced is excreted in urine without further metabolism 11) . It is well known that urinary 8-OHdG is elevated in smokers since cigarette smoke contains a large amount of oxygen-radical-forming substances 12) .…”

Section: Measurement Of Cavimentioning

confidence: 99%

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Association between Urinary 8-Hydroxydeoxyguanosine, an Indicator of Oxidative Stress, and the Cardio-Ankle Vascular Index in Hypertensive Patients

Masugata

Senda

Murao

et al. 2012

JAT

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Section: Association Between Cavi and Other Variablessupporting

confidence: 93%

Section: Measurement Of Cavimentioning

confidence: 99%

Association between Urinary 8-Hydroxydeoxyguanosine, an Indicator of Oxidative Stress, and the Cardio-Ankle Vascular Index in Hypertensive Patients

Masugata

Senda

Murao

et al. 2012

JAT

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“…• attack on guanine residues of DNA producing 8-OHdG 17,18 . Considering 8-OHdG is a major product and excreted in the urine without further metabolism, therefore, can be proposed as a biomarker of oxidative DNA damage in both nDNA and mtDNA [18][19][20] .…”

Section: Introductionmentioning

confidence: 99%

Administration of Purwoceng (<I>Pimpinella alpina</I> Molk) Improves Oxidative Stress Biomarker Following UVC Irradiation in Spargue-Dawley Male Rats

Nasihun

Widayati

2016

JNR

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Ipomoea reniformis Chaos is claimed in Indian traditional medical practice to be useful in the treatment of epilepsy and neurological disorders. In the present study, pretreatment effect of methanolic extract of Ipomoea reniformis on epilepsy and psychosis was evaluated in rodents using standard procedures. Besides evaluating epileptic and behavioral parameters, neurotransmitters such as Gamma-Amino Butyric Acid (GABA) in epilepsy and in psychosis dopamine, noradrenaline and serotonin contents in the rodent brain were estimated. The extract pretreatment reduced maximal electro shock; Isoniazid (INH) and Pentylenetetrazole (PTZ) induced seizures and also significantly inhibited the attenuation of brain GABA levels by INH and PTZ in mice. These results suggested that the observed beneficial effect in epilepsy may be by enhancing the GABAergic system. The test drug also inhibited the apomorphine induced climbing and stereotyped behavior and showed significantly reduced levels of brain dopamine, noradrenaline and serotonin which may be due to blocking of central dopaminergic, noradrenergic and serotonergic pathways or by enhancing the GABAergic system. The results obtained in present study suggest that the title plant possesses antiepileptic and antipsychotic activities in rodents.

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“…One of the main products of the oxidative degradation of DNA, 8-hydroxy-2'-deoxyguanosine (8OHdG), has been already proposed as biomarker of this process [96,97]. Yao et al [98] analyzed urinary levels of 8OHdG after solid-phase extraction by CE with amperometric detection.…”

Section: Nucleosides Nucleotides Rna and Dnamentioning

confidence: 99%

CE – a multifunctional application for clinical diagnosis

et al. 2007

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CE has been used widely as an analytical tool with high separation power taking advantage of size, charge-to-size ratio, or isoelectric point of various analytes. In combination with detection methods, such as UV absorption, electrochemical detection, fluorescence, or mass spectrometry (MS), it allows the separation and detection of inorganic and organic ions, as well as complex compounds, such as polypeptides, nucleic acids, including PCR amplicons from viruses or bacteria. Recent interest in identification of biomarkers of diseases using body fluids leads to development of CE-MS techniques. These applications allowed identification of new potential biomarkers for clinical diagnosis and monitoring of therapeutic interventions. In this report, we present a technical overview of various CE techniques and discuss their applications in clinical medicine.

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Determination of urinary oxidative DNA damage marker 8-hydroxy-2′-deoxyguanosine and the association with cigarette smoking

Cited by 51 publications

References 39 publications

Association between Urinary 8-Hydroxydeoxyguanosine, an Indicator of Oxidative Stress, and the Cardio-Ankle Vascular Index in Hypertensive Patients

Association between Urinary 8-Hydroxydeoxyguanosine, an Indicator of Oxidative Stress, and the Cardio-Ankle Vascular Index in Hypertensive Patients

Administration of Purwoceng (<I>Pimpinella alpina</I> Molk) Improves Oxidative Stress Biomarker Following UVC Irradiation in Spargue-Dawley Male Rats

CE – a multifunctional application for clinical diagnosis

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