This research was carried out to determine the yield and agronomic characteristics of some soybean genotypes under main crop conditions in the Eastern Mediterranean Transition Zone in the years 2021-2022. In the research, 13 varieties (Adel, AP-3773, Arısoy, Asya, Atakişi, Atlas-3616, J-112, Lider, Planet, Racer, Sonya, Winchester, Yemsoy) 1 genotype (Yeniköy-9) were used. The experiment was conducted in a randomized block design with three replications. It was determined that the average plant height varied between 64.05 cm (J-112) and 114.25 cm (Winchester). The lowest average first pods height (1.74 cm) was obtained from J-112 variety while the highest value (13.69 cm) was obtained from Yemsoy variety. The lowest number of branches per plant values i.e. 1.83 no. plant-1 and 2.13 no. plant-1 were recorded from J-112 and Planet variety respectively. In the experiment, the number of pods per plant varied between 72.20 pods plant-1 (Arısoy) to 105.61 pods plant-1 (AP-3773). However, the average weight of 100 seeds varied between 15.07 g (Asya) to 22.10 g (Lider). The lowest average protein content (33.58%) was obtained from Yemsoy variety while the highest value (41.50%) was obtained from J-112 variety. It was determined that the average seed yield varied between 379.74 kg da-1 (Arısoy) and 580.73 kg da-1 (Lider). According to the data obtained as a result of the experiment, Lider variety was come front with the highest seed yield (580.73 kg da-1) and, J-112 variety had the high protein content with 41.50%, Planet (21.96 g) and Yeniköy-9 (20.87 g) varieties had the highest 100 seed weight. According to production goals, one of this superior varieties may be prefer to grow in the Eastern Mediterranean Transition Zone.