Determination of β-lactam antibiotics in milk based on magnetic molecularly imprinted polymer extraction coupled with liquid chromatography–tandem mass spectrometry

Zhang, Xiaopan; Chen, Ligang; Xu, Yang; Wang, Hui; Zeng, Qinglei; Zhao, Qi; Ren, Nanqi; Liu, Ding

doi:10.1016/j.jchromb.2010.10.030

Cited by 74 publications

(26 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Urraca et al developed one such method for the β-lactams using fluorescently labelled competitors [24], and Wan et al developed a chemiluminescence assay [25]. Other researchers have only developed MIPs for extraction of the antibiotics and later perform liquid chromatography using polymercoated columns with mass spectrometry for quantification of the antibiotic [26]. In some regards the MIP are similar to immunoassays or receptor-based assays in that the analyte competes for a receptor but, strictly speaking, are not "bio"-analytical because detection is achieved by use of polymers.…”

Section: Current Detection Methodsmentioning

confidence: 99%

Current bioanalytical methods for detection of penicillins

et al. 2012

View full text Add to dashboard Cite

Section: Current Detection Methodsmentioning

confidence: 99%

Current bioanalytical methods for detection of penicillins

et al. 2012

View full text Add to dashboard Cite

“…Posteriormente os analitos foram analisados por LC-MS. A partir das análi-ses, foi possível observar bons níveis de recuperação e baixos limites de detecção e quantificação para β-lactâmicos. Em comparação com méto-dos convencionais, a utilização do MIP magné-tico permitiu, de maneira rápida e fácil, a separação e identificação dos analitos de interesse [109] .…”

Section: Polímeros Magnéticos Molecularmente Impressos -Mips Magnéticosunclassified

Emprego de polímeros de impressão molecular em preparo de amostras para análise de compostos orgânicos: aplicações e tendências

Santos¹,

Abrão²,

Freitas³

et al. 2012

View full text Add to dashboard Cite

ResumoOs polímeros de impressão molecular são materiais sintéticos dotados de sítios específicos de reconhecimento. Esses materiais são obtidos por reações de polimerização que fixam, estrategicamente, monômeros funcionais ao redor de uma molécula modelo de acordo com os grupos ligantes e com a estereoquímica de ambas as moléculas. Os MIPs têm sido amplamente empregados em procedimentos de preparo de amostras, como extração e microextração em fase sólida, extração sortiva em barra de agitação, extração com adsorvente magnético, microextração com sorvente empacotado, entre outras. Este artigo de revisão tem como objetivo apresentar o que há de mais recente no emprego de MIP para extração de compostos orgânicos, evidenciando as vantagens de cada aplicação, bem como as mais promissoras tendências que sustentam a evolução e o aperfeiçoamento de cada técnica. Palavras-chavePolímeros de impressão molecular; MIP; preparo de amostras.Molecularly imprinted polymers in sample preparation for organic compounds analysis: applications and trends AbstractMolecularly imprinted polymers are synthetic materials with molecular recognition ability. These materials are obtained by polymerization reactions that fix the functional monomers around the template molecule according with the binding groups and the stereochemistry of both molecules. The MIPs have been extensively used in several applications with emphasis for sample preparation procedures as solid phase extraction, solid phase microextraction, extraction by magnetic sorbents, microextraction by packed sorbent among others. So, the objective of this review is to present the novelty in MIP use for organic compounds extraction and point out the advantages of each application, as well as what is most promising in the evolution and improvement of each technique.

show abstract

“…This has encouraged many workers to prepare magnetic imprinted polymers having specificity towards chloramphenicol [28], sulfonylurea [29], oxytetracycline [30], β-lactam antibiotic [31], protocatechuic acid [32], macrolide antibiotics [33], metronidazole [34], levofloxacin [35], polychlorinated biphenyls [36], erythromycin [37]. The present work focuses on synthesis of cefquinome specific magnetic polymer and its use in extraction of the antibiotic from food matrix.…”

Section: Introductionmentioning

confidence: 99%

Extraction of Cefquinome from Food by Magnetic Molecularly Imprinted Polymer

Aggarwal¹,

Ys²,

Sharma³

et al. 2016

Pharm Anal Acta

View full text Add to dashboard Cite

Objectives: Cefquinome is a fourth generation cephalosporin with broad spectrum antimicrobial activity. It is commonly used against respiratory tract diseases, acute mastitis, calf septicemia and foot rot in livestock. Clean-up step in sample preparation is invariably required for avoiding interferences in assay from other components. It is envisaged to prepare molecular imprinted based polymer with desired selectivity for cefquinome. Method: Imprinted polymer was synthesized over the surface of magnetite using methacrylate (monomer) acid and ethyleneglycoldimethacrylate (crosslinker) in the presence of cefquinome (imprint molecule). Magnetite was prepared by co-precipitation of 1.98 g FeCl 2 .4H 2 O and 5.41 g FeCl 3 .6H 2 O. Magnetic non-imprinted polymer was prepared similarly in absence of cefquinome. Selectivity in different solvent was calculated from partition coefficient values in imprinted and non-imprinted polymers. Result: Selectivity of imprinted polymer over non-imprinted polymer was dependent on nature of solvent and pH. Binding of cefquinome was highly selective in acetonitrile. Imprinted polymer lacks selectivity in methanol and 1M NaCl. Ionic interaction between quinolinium ion in cefquinome and carboxylate anion in polymer appears to be major force for recognition of cefquinome by imprinted polymer. Prepared polymer extracted cefquinome from milk, honey, egg and water and extraction efficiency was in the range of 74-93.7%. Conclusion: Selectivity of magnetic imprinted polymer must be determined in different solvents and this will enable selecting binding and elution conditions during extraction of imprint molecule.

show abstract

Determination of β-lactam antibiotics in milk based on magnetic molecularly imprinted polymer extraction coupled with liquid chromatography–tandem mass spectrometry

Cited by 74 publications

References 42 publications

Current bioanalytical methods for detection of penicillins

Current bioanalytical methods for detection of penicillins

Emprego de polímeros de impressão molecular em preparo de amostras para análise de compostos orgânicos: aplicações e tendências

Extraction of Cefquinome from Food by Magnetic Molecularly Imprinted Polymer

Contact Info

Product

Resources

About