Determining in vitro anticancer activity of mitomycin C loaded microemulsion

Kotmakchiev, Mustafa; Çetintaş, Vildan Bozok; Kantarcı, Gülten

doi:10.1016/j.copbio.2011.05.416

Cited by 3 publications

(2 citation statements)

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“…The proper microemulsion delivery systems of some anticancer drugs have showed decreased cytotoxic effect and have improved the efficacy of the drug ( Figure 2 and Table 2). The in vitro evaluation of mitomycin C loaded in microemulsion revealed safe effect when subjected unto Calu1 and A549 lung carcinoma cell lines [40]. Another promising study proved that an oil-in-water microemulsion containing cremophor EL, ethanol, propylene glycol and saline solution would be a good candidate as an intravenous delivery of diallyl trisulfide which is an oil-soluble sulfur compound that induces apoptosis in tumor cells [41].…”

Section: Clinical Trialsmentioning

confidence: 97%

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Impact of Nanoparticles on Cancer Therapy

Alkhatib¹,

Albishi²,

Mahassni³

2013

Trop. J. Pharm Res

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The tremendous contribution of nanotechnology to the treatment and diagnosis of medical diseases has recently attracted the attention of anticancer researchers. Most of the new nanoparticle carriers have improved drug bioavailability and reduced the cytotoxic effects of the drugs. This article presents an overview of the recent advances of nanotechnology in cancer therapy. It covers the mechanisms of cellular uptake for anticancer drugs delivered in nanoscale systems by either active or passive targeting. The various nanoscale systems employed in drug delivery and their immense potential in diagnosis andimaging of cancerous tumors are also addressed.

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Section: Clinical Trialsmentioning

confidence: 97%

“…In vivo and in vitro evaluation for the mitomycin C, diallyl trisulfide and adriamycin, when loaded in microemulsion [40,41,42].…”

Section: Clinical Trialsmentioning

confidence: 99%