Determining Role of TGF-β3 in Some Treatments of Albino Mouse, Mus musculus Linnaeus, 1758 Infected with Hydatid Cyst by Using an Immunohistoflourescent Staining Technique

Abstract

The present study was conducted as an attempt to treat secondary hydatid disease in white mice strain Balb/c by immunohistoflourescent (IHF) staining technique. For this purpose, the mice were infected with hydatid cysts and treatment was done by oxfendazole (OFZ) at a concentration of 30 mg/kg, praziquantel (PZQ) at a concentration of 40 mg/kg and albendazole (ABZ) at a concentration of 10 mg/kg of body weight. Each drug was given weekly for four months and the same concentrations as above. The results showed that the highest treatment efficiency was in case of OFZ + PZQ treated mice, while the groups treated with OFZ, OFZ + ABZ and ABZ + PZQ showed less treatment efficiency, respectively. The IHF staining technique was used to determine the cytokinesis of TGF-β3 in the spleen and liver of experimental mice. For this reason, OFZ is considered as one of the most promising chemotherapies used in the treatment of hydatid cysts.

Histopathological Changes in the Liver and Spleen of Albino Mouse, Mus musculus Linnaeus, 1758 Experimentally Infected with the Hydatid Cyst of Echinococcus granulosus (Batsch, 1786) and Its Treatments with Oxfendazole

“…Because of the importance of hydatid cyst disease from human health and veterinary point of view, it has been adopted experimentally to infect mice, as they are similar model to humans in order to study the growth and development of the parasite and its role by clarifying the relationship between the parasite and the host (Fotiadis et al, 1999). Recently, Sadek (2022) investigated the efficacy of oxfendazole, praziquantel and albendazole in treatment of albino mice, experimentally infected with hydatid cysts.…”