The present study was conducted as an attempt to treat secondary hydatid disease in white mice strain Balb/c by immunohistoflourescent (IHF) staining technique. For this purpose, the mice were infected with hydatid cysts and treatment was done by oxfendazole (OFZ) at a concentration of 30 mg/kg, praziquantel (PZQ) at a concentration of 40 mg/kg and albendazole (ABZ) at a concentration of 10 mg/kg of body weight. Each drug was given weekly for four months and the same concentrations as above. The results showed that the highest treatment efficiency was in case of OFZ + PZQ treated mice, while the groups treated with OFZ, OFZ + ABZ and ABZ + PZQ showed less treatment efficiency, respectively. The IHF staining technique was used to determine the cytokinesis of TGF-β3 in the spleen and liver of experimental mice. For this reason, OFZ is considered as one of the most promising chemotherapies used in the treatment of hydatid cysts.

The present study was conducted as an attempt to chemically treat secondary hydatid cyst disease in the Albino mouse Mus musculus strain Balb/c. Oxfendazole (OFZ) was used at a concentration of 30 mg/kg, and the histopathological changes in the liver and spleen were examined. The efficiency of the drug was observed compared to the positive untreated control group. However, some histopathological changes were noticed in liver and spleen of the OFZ-treated mice.

This study was conducted to investigate the effect of a number of drugs on the viability of primary protoscolices isolated from sheep infected with the larval stage of E. granulosus. These drugs included Oxfendazole (OFZ) at a concentration of 0.05 mg/ml, mixed with Praziquantel (PZQ) at a concentration of 4 mg/ml and Albendazole (ABZ) at a concentration of 1 mg/ml. The results showed that OFZ was the most effective in influencing the viability of the protoscolices. The percentage of killing after five minutes of treatment was 85.63% and it was 17.21%, 15.10% and 13.09% for OFZ+ABZ, OFZ+PZQ and ABZ+PZQ, respectively. After 30 minutes, the killing percentage was 99.04%, 71.63%, 40.19% and 31.09%, respectively. The percentage of killing reached 100% after 35 minutes, 40 minutes, 2 hours and 3 hours, respectively. The results confirm the use of OFZ as a lethal drug, or a viability-suppressant for protoscolices in the future, after conducting more researches to know the side effects of this drug in laboratory animals for access to the best treatment to those infected with hydatid cysts.