In order to prevent the unsafe self-and mutual-rescue behavior in confined space working accidents, the index system of risk factors for emergency rescue was established, including unsafe behavior, unsafe behavior premise, unsafe supervision and organizational impact of the four parts. The factor sets of causes and results were analyzed by integrating decision-making trial and evaluation laboratory (DEMATEL), the interpretative structural model (ISM) was used to analyze the hierarchical structure of influence factors. The study find that, the unsafe self-and mutual-rescue behavior in confined space working accidents is the direct factor, the intermediate factor and the deep factor synthesis function result. Failure factors such as the rescue drills are insufficient and formalized, the leaders' safety awareness and emergency handling ability are low, the operation managers' emergency early warning and risk management ability are insufficient, the self-and mutual-rescue personnel do not wear protective equipment and failure to establish coordination and linkage mechanism with relevant units and social organizations may easily lead to the risk of self-and mutual-rescue, need to focus on.