Determining the Acute Toxicity of New Preparation Vetom 20.76 on Geese and Ducks

Ноздрин, Г. А.; Utkina, R. G.; Lelyak, Anastasia Aleksandrovna; Novik, Yana Viktorovna

doi:10.17582/journal.sja/2020/36.2.470.477

Cited by 4 publications

(2 citation statements)

References 8 publications

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“…When using Vetom 1, the populations of these microorganisms in the gastrointestinal tract of pigs were synergistic in relation to each other and showed a positive correlation dependence of the average intensity. No correlation dependences were found between [4]. Требуется поиск новых безопасных препаратов, которые в условиях применения других средств для лечения не будут иметь дополнительного негативного воздействия на состояние животного [5].…”

Section: Novosibirsk State Agrarian University Novosibirsk Russiaunclassified

Changes in the microflora of the intestinal tract of pigs when using Vetom 1

Savchenko

Mokrinskaya

Barsukova

et al. 2020

Sib. vestn. s-h. nauki

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The effect of the probiotic preparation Vetom 1 was studied on the quantitative indicators of microflora of gastrointestinal tract of pigs of the Large White breed kept at a pig farm. Vetom 1 is a powder for oral administration and rectal administration, containing dry bacterial mass of live spore-forming bacteria of Bacillus subtilis DSM 32424 strain. Based on the analogue principle, experimental and control groups of 10 animals in each were formed. Pigs of the experimental group were given Vetom 1 at a dose of 75 mg/kg of live body weight once a day every day for 15 days. When applied, the concentration of bifidobacteria increased. Vetom 1 did not affect the dynamics of the concentration of lactobacilli, enterobacteria and fungi in the gastrointestinal tract of pigs. Under the influence of the preparation, the correlation dependences between different populations of microorganisms of the gastrointestinal tract of animals changed. Without the use of the probiotic preparation, the concentrations of lactobacilli and bifidobacteria inversely correlated with each other with an average intensity. When using Vetom 1, the populations of these microorganisms in the gastrointestinal tract of pigs were synergistic in relation to each other and showed a positive correlation dependence of the average intensity. No correlation dependences were found between concentrations of enterobacteria and other studied microorganisms. Without the use of the probiotic preparation, concentrations of bifidobacteria and fungi inversely correlated with each other with a strong intensity. When Vetom 1 was used, the populations of these microorganisms in the gastrointestinal tract of pigs did not show either synergistic or antagonistic activity among themselves, since the confidence interval of the correlation coefficient equaled zero.

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Section: Novosibirsk State Agrarian University Novosibirsk Russiaunclassified

Changes in the microflora of the intestinal tract of pigs when using Vetom 1

Savchenko

Mokrinskaya

Barsukova

et al. 2020

Sib. vestn. s-h. nauki

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“…Поиск и применение новых кормовых средств и технологических приемов, которые бы обеспечили не только высокий уровень сохранности поголовья, но и продуктивности является необходимым условием современного промышленного птицеводства [1,2]. Микрофлора, населяющая желудочно-кишечный тракт, напрямую связана с состоянием здоровья и продуктивности птицы, поэтому для формирования нормальной микрофлоры желудочно-кишечного тракта важным становится применение пробиотиков на основе живых культур бактерий [3-5].…”

Section: Introductionunclassified

Effect Ofprobiotic Products Based on Bacillus Subtilis on Gosling Weight

Novik¹,

Nozdrin²,

Nozdrin³

2022

VAGAU

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У гусей из самых быстрых темпов роста среди одомашненных птиц, выращиваемых для производства мяса, живая масса гусенка за 2 мес. выращивания увеличивается больше чем в 40 раз. Из всех видов птиц гусей отличает биологическая особенность, заключающаяся в потреблении большого количества клетчатки, обладающей пребиотическими свойствами, что в свою очередь обуславливает возможность активного использования пробиотических штаммов микроорганизмов. Использовали оптимальное сочетание пробиотиков, дозировок и сроков их исследований для гусей краснозерской породы в возрасте от 14 до 104 дней. Место проведения исследований: ООО Научнопроизводственная фирма «Исследовательский центр», Новосибирская область, в выборке гусят-бройлеров. По принципу пар-аналогов были сформированы 9 групп гусей, по 10 птиц в каждой группе: 7 опытных и 1 контрольная. Гусям опытных групп дополнительно с комбикормом давали препараты «Ветом 1» и «Ветом 2» в различных дозировках, с разными схемами применения, гусям из контрольной группы пробиотические препараты не давали. Установлено стимулирующее влияние на интенсивность роста гусят пробиотического препарата «Ветом 1» в дозе 50 мг/кг массы при кормлении 1 раз в сутки в течение 15 сут., «Ветома 2» -в дозе 75 мг/кг массы при кормлении 1 раз в сутки, циклами по 5 сут. с 5-суточными интервалами, всего назначений 15. С учетом условий производства наиболее рациональным будет применение пробиотического препарата «Ветом 1» в дозе 50 мг/кг массы при кормлении 1 раз в сутки в течение 15 сут.

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Biochemical studies of blood of experimental rats in assessing acute oral toxicity of Vetom 20.76 based on the predatory fungus <em>Arthrobotrys оligospora</em>

Utkina

Ноздрин

2023

Vestn. Novosib. gos. agrar. univ.

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The effect of the experimental preparation Vetom 20.76 based on Arthrobotrys oligospora on the biochemical blood parameters of experimental rats was shown. A complex of preclinical studies to study acute toxicity was carried out on nonlinear white rats (females) at eight weeks of age. Four experimental and one control group were formed. Animals from the experimental groups were injected once with the test drug in the range of test doses (5 µl/kg, 50 µl/kg, 300 µl/kg, 5000 µl/kg). The experimental animals were observed daily for 14 days. The animals of the experimental groups had positive growth and development dynamics even at the drug dosage of 5000 µl/kg. A complex of blood biochemical studies was investigated during preclinical studies in experimental animals. The primary biochemical indicators of blood serum studied during the experiment: total protein (g/L), albumin (g/L), globulin (g/L), creatinine (μmol/L), ALT (U/L), glucose (mmol/L), phosphorus (mmol/L), calcium (mmol/L), potassium (mmol/L), sodium (mmol/L) and total cholesterol (mmol/L). At the end of the study, we stated the improvement of indicators characterizing metabolic processes and protective function of the body of experimental rats as a result of using the drug, both relative to the original data and compared with counterparts from the control. During the study, all biochemical indices of the blood serum of the experimental rats in the studied groups remained within the physiological norm, indicating the drug’s safety. Furthermore, no undesirable side effects were recorded in the animals, even when using Vetom 20.76 at the maximum dose. Therefore, Vetom 20.76 was assigned to the fourth toxicity class according to SS (State Standard) 12.1.007-76.

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Determining the Acute Toxicity of New Preparation Vetom 20.76 on Geese and Ducks

Cited by 4 publications

References 8 publications

Changes in the microflora of the intestinal tract of pigs when using Vetom 1

Changes in the microflora of the intestinal tract of pigs when using Vetom 1

Effect Ofprobiotic Products Based on Bacillus Subtilis on Gosling Weight

Biochemical studies of blood of experimental rats in assessing acute oral toxicity of Vetom 20.76 based on the predatory fungus <em>Arthrobotrys оligospora</em>

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