Determining the ideal prevention strategy for multidrug-resistance organisms in resource-limited countries: a cost-effectiveness analysis study

Wang, Ying; Yua, Yuan; Lin, Likai; Tan, Xiaodong; Tan, Yibin

doi:10.1017/s0950268820001120

Cited by 2 publications

(1 citation statement)

References 53 publications

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“…The most common pathogen of focus was MRSA, whilst others included minority multi-drug resistant tuberculosis, HIV, gonorrhoea, carbapenem-resistant Enterobacteriaceae . Of the nine studies that did not specify an individual pathogen, they either described the class or location of infections, such as acute respiratory or LRTIs, intrabdominal infections, bloodstream infections, sepsis, nosocomial infections and multi-drug resistant organisms [ 33 , 42 , 46 , 47 , 49 , 55 , 56 , 58 , 60 ].…”

Section: Resultsmentioning

confidence: 99%

A systematic literature review of economic evaluation studies of interventions impacting antimicrobial resistance

Painter

Faradiba

Chavarina

et al. 2023

Antimicrob Resist Infect Control

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Background Antimicrobial resistance (AMR) is accelerated by widespread and inappropriate use of antimicrobials. Many countries, including those in low- and middle- income contexts, have started implementing interventions to tackle AMR. However, for many interventions there is little or no economic evidence with respect to their cost-effectiveness. To help better understand the scale of this evidence gap, we conducted a systematic literature review to provide a comprehensive summary on the value for money of different interventions affecting AMR. Methods A systematic literature review was conducted of economic evaluations on interventions addressing AMR. a narrative synthesis of findings was produced. Systematic searches for relevant studies were performed across relevant databases and grey literature sources such as unpublished studies, reports, and other relevant documents. All identified economic evaluation studies were included provided that they reported an economic outcome and stated that the analysed intervention aimed to affect AMR or antimicrobial use in the abstract. Studies that reported clinical endpoints alone were excluded. Selection for final inclusion and data extraction was performed by two independent reviewers. A quality assessment of the evidence used in the included studies was also conducted. Results 28,597 articles were screened and 35 articles were identified that satisfied the inclusion criteria. The review attempted to answer the following questions: (1) What interventions to address AMR have been the subject of an economic evaluation? (2) In what types of setting (e.g. high-income, low-income, regions etc.) have these economic evaluations been focused? (3) Which interventions have been estimated to be cost-effective, and has this result been replicated in other settings/contexts? (4) What economic evaluation methods or techniques have been used to evaluate these interventions? (5) What kind and quality of data has been used in conducting economic evaluations for these interventions? Discussion The review is one of the first of its kind, and the most recent, to systematically review the literature on the cost-effectiveness of AMR interventions. This review addresses an important evidence gap in the economics of AMR and can assist AMR researchers’ understanding of the state of the economic evaluation literature, and therefore inform future research. Systematic review registration PROSPERO (CRD42020190310).

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