Determining the Impact of Roller Compaction Processing Conditions on Granule and API Properties

Clarke, James Freeman; Gamble, John F.; Jones, John W.; Tobyn, Mike; Dawson, Neil; Davies, Conrad; Ingram, Andrew; Greenwood, R.

doi:10.1208/s12249-020-01773-2

Cited by 8 publications

(3 citation statements)

References 47 publications

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“…al., there was still over a third of the material has not been compacted into granules even though the force between rollers is so great that these materials are already over-compacted and cannot be used for secondary compression in tablet forming: according to figure 1 and 2, there is always a 40%-45% fine particles present no matter how roller gap changes [2]. Clarke et al, the relationship between roll gap (pression force) and fraction volume [2]. The mass of un-compacted matter also increases significantly as the feeding auger and roller speed increase to enlarge producing rate, and these fragments cannot be used in tablet forming.…”

Section: Challengesmentioning

confidence: 99%

“…Figure 1. Adapted fromClarke et al, the relationship between roll gap (pression force) and fraction volume[2]. The mass of un-compacted matter also increases significantly as the feeding auger and roller speed increase to enlarge producing rate, and these fragments cannot be used in tablet forming.…”

mentioning

confidence: 99%

“…Figure 2. Adapted from Clarke et al, the relationship between feed auger speed and fraction percentage[2]. According to Taipale et.…”

mentioning

confidence: 99%

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Research on the challenges and improvements of the roller compaction process for dry granulation

Shen

2023

ACE

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The analysis of the challenges for roller compaction (RC) in the dry granulation (DG) pharmaceutical industry process and their relative improvements are presented based on the review of previous research done by others. According to research between the 2000s and 2010s, magnifying the benefit that already obtains has been the main improvement of RC, such as increasing production efficiency and stability. Although modifications also reduced some of the disadvantages, such as reducing the use of raw material and waste, these improvements are still too limited, and some serious limitations still hindered the application of RC: the three major issues were: the large number of fragments producing, relatively fragile tablet, and the easy breaking ribbon. However, some research that took place later quickly fixed the limitation and make RC more applicable. This review briefly summarizes the issues that exist in the RC process, the improvements that have already been done to improve RC, and the limitations that RC still has.

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Section: Challengesmentioning

confidence: 99%

mentioning

confidence: 99%