Alternative radiological methods have been searched to improve early breast cancer detection. A prototype of a hybrid ultrasound tomography scanner was constructed as a novel non-invasive breast cancer screening method. The results of measurements with the new instrument were compared to conventional breast ultrasound, mammography, and magnetic resonance data from these same patients. The estimated hybrid ultrasound tomography scanner sensitivity was 74%, and specificity was 68%. Although these results do not match classical radiological methods yet, this preliminary report confirms the ability of the hybrid ultrasound tomography scanner to detect and visualize different types of breast lesions including breast cancer, providing a rationale for further research.