Deterministic fractionation of binary suspensions moving past a line of microposts

Devendra, R.; Drazer, Germán

doi:10.1007/s10404-013-1328-0

Cited by 8 publications

(6 citation statements)

References 43 publications

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“…Comparison of the data collected with microfluidic data in Ref 26 and Ref. 35 showing good agreement across different length scales. The dashed lines correspond to constant non-dimensional roughness 10 -3 , 10 -2 , and 10 -1 from the bottom.…”

Section: B Scaling Behaviormentioning

confidence: 57%

Inertia and scaling in deterministic lateral displacement

2013

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The ability to separate and analyze chemical species with high resolution, sensitivity, and throughput is central to the development of microfluidics systems. Deterministic lateral displacement (DLD) is a continuous separation method based on the transport of species through an array of obstacles. In the case of force-driven DLD (f-DLD), size-based separation can be modelled effectively using a simple particle-obstacle collision model. We use a macroscopic model to study f-DLD and demonstrate, via a simple scaling, that the method is indeed predominantly a sizebased phenomenon at low Reynolds numbers. More importantly, we demonstrate that inertia effects provide the additional capability to separate same size particles but of different densities and could enhance separation at high throughput conditions. We also show that a direct conversion of macroscopic results to microfluidic settings is possible with a simple scaling based on the size of the obstacles that results in a universal curve. V C 2013 AIP Publishing LLC.

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Section: B Scaling Behaviormentioning

confidence: 57%

Inertia and scaling in deterministic lateral displacement

2013

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“…In addition, the particles experience an electrophoretic force that depends on their charge, but their motion is usually dominated by the electroosmotic flow, specially in buffered solutions. [13][14][15][16] The direction of the driving field is controlled by the orientation of the PDMS channel with respect to the array of obstacles. Therefore, we performed experiments for different angles of the driving field by changing the orientation of the channel, which was reversibly attached to the glass slide.…”

Section: Experimental Setup and Methodmentioning

confidence: 99%

Electrokinetically driven deterministic lateral displacement for particle separation in microfluidic devices

Hanasoge

Devendra

Díez

et al. 2014

Microfluid Nanofluid

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An electrokinetically-driven deterministic lateral displacement (e-DLD) device is proposed for the continuous, two-dimensional fractionation of suspensions in microfluidic platforms. The suspended species are driven through an array of regularly spaced cylindrical posts by applying an electric field across the device. We explore the entire range of orientations of the driving field with respect to the array of obstacles and show that, at specific forcing-angles, particles of different size migrate in different directions, thus enabling continuous, two-dimensional separation. We discuss a number of features observed in the kinetics of the particles, including directional locking and sharp transitions between migration angles upon variations in the direction of the force, that are advantageous for high-resolution two-dimensional separation. A simple model based on individual particle-obstacle interactions accurately describes the migration angle of the particles depending on the orientation of the driving field, and can be used to re-configure driving field depending on the composition of the samples.

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“…Although DLD was initially introduced as a flow-driven, passive microfluidic method for size separation, we have shown in previous work that driving the particles by external forces also results in separation depending on the orientation of the force with respect to the array of obstacles. Specifically, we have successfully used gravity and electric fields to drive the separation of suspended particles in force-driven DLD (f-DLD) [28]- [31]. In their original work, Inglis et al observed two different types of trajectories, depending on the size of the particles: bump mode trajectories for larger particles and zigzag mode trajectories for smaller ones [32].…”

Section: Introductionmentioning

confidence: 99%

Deterministic separation of suspended particles in a reconfigurable obstacle array

Du¹,

Drazer²

2015

J. Micromech. Microeng.

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We use a macromodel of a flow-driven deterministic lateral displacement (DLD) microfluidic system to investigate conditions leading to size-separation of suspended particles. This model system can be easily reconfigured to establish an arbitrary orientation between the average flow field and the array of obstacles comprising the stationary phase (forcing angle). We also investigate the effect of obstacle size using two arrays with different obstacles but same surface-to-surface distance between them. In all cases, we observe the presence of a locked mode at small forcing angles, in which particles move along a principal direction in the lattice until a locked-to-zigzag transition takes place when the driving force reaches a critical angle. We show that the transition occurs at increasing angles for larger particles, thus enabling particle separation at specific forcing angles. Moreover, we observe a linear correlation between the critical angle and the size of the particles that could be used in the design of microfluidic systems with a fixed orientation of the flow field. Finally, we present a simple model, based on the presence of irreversible interactions between the suspended particles and the obstacles, which describes the observed dependence of the migration angle on the orientation of the average flow.

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Deterministic fractionation of binary suspensions moving past a line of microposts

Cited by 8 publications

References 43 publications

Inertia and scaling in deterministic lateral displacement

Inertia and scaling in deterministic lateral displacement

Electrokinetically driven deterministic lateral displacement for particle separation in microfluidic devices

Deterministic separation of suspended particles in a reconfigurable obstacle array

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