2022
DOI: 10.3390/jof9010051
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Detoxication of Citrinin with Kojic Acid by the Formation of the Citrinin-Kojic Acid Adduct, and the Enhancement of Kojic Acid Production by Citrinin via Oxidative Stress in Aspergillus parasiticus

Abstract: Our previous work showed that citrinin (CTN) produced bay Penicillium citrinum inhibited the production of aflatoxin by Aspergillus parasiticus. We also reported that CTN was non-enzymatically converted to a novel CTN-KA adduct with kojic acid (KA) in aqueous condition. We herein observed that unlike CTN, the CTN-KA adduct does not show antimicrobial activity against Escherichia coli or Bacillus subtilis or any cytotoxic effect on HeLa cells, suggesting that CTN was detoxified by KA by the formation of the CTN… Show more

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“…[42] that showed antifungal activity against the mould Sclerotinia sclerotiorum, which is a common plant pathogen [43], and other fungi, such as Aspergillus niger or Rhizopus oryzae [44]. Furthermore, this metabolite produced by Aspergillus parasiticus can detoxify the mycotoxin citrinin in a glucose yeast agar medium [45]. The presence of kojic acid in all the batches may be due to the contamination of the chestnuts by different moulds before preparing the culture medium.…”
Section: Fungal Secondary Metabolitesmentioning
confidence: 99%
“…[42] that showed antifungal activity against the mould Sclerotinia sclerotiorum, which is a common plant pathogen [43], and other fungi, such as Aspergillus niger or Rhizopus oryzae [44]. Furthermore, this metabolite produced by Aspergillus parasiticus can detoxify the mycotoxin citrinin in a glucose yeast agar medium [45]. The presence of kojic acid in all the batches may be due to the contamination of the chestnuts by different moulds before preparing the culture medium.…”
Section: Fungal Secondary Metabolitesmentioning
confidence: 99%