Detoxification of ochratoxin A and zearalenone by Pleurotus ostreatus during in vitro gastrointestinal digestion

Nobre, Clarisse; González, Alondra; Losoya‐Sifuentes, Carolina; Teixeira, J. A.; Belmares, Ruth; Abrunhosa, Luı́s

doi:10.1016/j.foodchem.2022.132525

Cited by 9 publications

(7 citation statements)

References 39 publications

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“…The harmonized INFOGEST in vitro digestion model (static method) mimicking the mouth, stomach, and small intestine conditions [ 21 ] was applied to the digestion of the Aloe vera juices (non-fermented and fermented ones), with small modifications [ 22 , 23 ]. Table 1 shows the composition of the electrolyte stock solutions used during in vitro digestion, namely, simulated salivary fluid (SSF), simulated gastric fluid (SGF), and simulated intestinal fluid (SIF).…”

Section: Methodsmentioning

confidence: 99%

Effect of Gastrointestinal Digestion on the Bioaccessibility of Phenolic Compounds and Antioxidant Activity of Fermented Aloe vera Juices

et al. 2022

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Plant-based beverages are enriched by the fermentation process. However, their biocompounds are transformed during gastrointestinal digestion, improving their bioaccessibility, which is of primary importance when considering the associated health benefits. This study aimed to evaluate the effect of in vitro gastrointestinal digestion on phenolic compound bioaccessibility and antioxidant activity of novel Aloe vera juices fermented by probiotic Enterococcus faecium and Lactococcus lactis. Aloe vera juices were digested using the standardized static INFOGEST protocol. During digestion, phenolic compounds and antioxidant activity (DPPH, ABTS, and FRAP) were accessed. The digestion process was seen to significantly increase the total phenolic content of the fermented Aloe vera juices. The fermentation of Aloe vera increased the bioaccessibility of juice biocompounds, particularly for kaempferol, ellagic acid, resveratrol, hesperidin, ferulic acid, and aloin. The phenolics released during digestion were able to reduce the oxidative radicals assessed by ABTS and FRAP tests, increasing the antioxidant action in the intestine, where they are absorbed. The fermentation of Aloe vera by probiotics is an excellent process to increase the bioavailability of beverages, resulting in natural added-value functional products.

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Section: Methodsmentioning

confidence: 99%

Effect of Gastrointestinal Digestion on the Bioaccessibility of Phenolic Compounds and Antioxidant Activity of Fermented Aloe vera Juices

et al. 2022

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“…Taking advantage of their low cost, wide applicability, and recyclability, natural materials can be used as adsorbents for OTA removal in liquid matrices. Most of these materials come from plants, especially agricultural by-products such as jujube stones, oyster mushroom powder, dried fruit shells, olive pomace, and other fruit wastes that have been reported in the literature [ 42 , 43 , 44 ]. Adsorbents adsorb fungal toxins on the surface of the material through electrostatic forces, hydrogen bonds, and van der Waals forces, reducing absorption in the gastrointestinal tract and purifying the liquid matrix.…”

Section: Physical Methodsmentioning

confidence: 99%

“…However, the authors only changed the pH value during their in vitro experiments, while the detoxification process in the gastrointestinal environment is complex. Therefore, Nobre et al [ 43 ] further simulated the in vivo gastrointestinal environment and studied the in vitro gastrointestinal detoxification effect of powdered pleurotus otreatus (PO) on OTA and ZEN. They found that an OTA hydrolase present in PO can hydrolyze and detoxify OTA, while PO removes ZEN through adsorption.…”

Section: Physical Methodsmentioning

confidence: 99%

Ochratoxin A: Overview of Prevention, Removal, and Detoxification Methods

Ding,

Han,

Wang

et al. 2023

Toxins

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Ochratoxins are the secondary metabolites of Penicillium and Aspergillus, among which ochratoxin A (OTA) is the most toxic molecule. OTA is widely found in food and agricultural products. Due to its severe nephrotoxicity, immunotoxicity, neurotoxicity, and teratogenic mutagenesis, it is essential to develop effective, economical, and environmentally friendly methods for OTA decontamination and detoxification. This review mainly summarizes the application of technology in OTA prevention, removal, and detoxification from physical, chemical, and biological aspects, depending on the properties of OTA, and describes the advantages and disadvantages of each method from an objective perspective. Overall, biological methods have the greatest potential to degrade OTA. This review provides some ideas for searching for new strains and degrading enzymes.

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“…Powder of oyster mushroom Pleurotus ostreatus was recently studied for possible detoxification of OTA and ZEA by simulation of in vitro gastrointestinal digestion in the absence and presence of cornmeal and ground feed. It was found that Pleurotus ostreatus has a great potential to detoxify OTA ( 187 ) ( Table 2 ).…”

Section: Biological Supplements Given As Feed Additives To Prevent My...mentioning

confidence: 99%

Natural feed additives and bioactive supplements versus chemical additives as a safe and practical approach to combat foodborne mycotoxicoses

Stoev

2024

Front. Nutr.

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This review highlights the possible hazard of mycotoxins occurrence in foods and feeds in regards to foodborne diseases. The possible management of the risk of contamination of foods and feeds with mycotoxins by using natural feed additives, protecting against deleterious effects of mycotoxins or inhibiting the growth of fungi and mycotoxin production, is deeply investigated in the available literature and some effective measures for safe utilization of mycotoxin contaminated feed/food are proposed. The biological methods of decontamination, degradation or biotransformation of mycotoxins are deeply analyzed and discussed. Some natural antagonists against target fungi are also reviewed and a comparison is made with conventional fungicides for ensuring a safe prevention of mycotoxin contamination. The most common and useful chemical methods of mycotoxins decontamination of agricultural commodities or raw materials are also investigated, e.g., chemical additives inactivating or destroying and/or adsorbing mycotoxins as well as chemical additives inhibiting the growth of fungi and mycotoxin production. The practical use and safety of various kind of feed/food additives or herbal/biological supplements as possible approach for ameliorating the adverse effects of some dangerous mycotoxins is deeply investigated and some suggestions are given. Various possibilities for decreasing mycotoxins toxicity, e.g., by clarifying the mechanisms of their toxicity and using some target antidotes and vitamins as supplements to the diet, are also studied in the literature and appropriate discussions or suggestions are made in this regard. Some studies on animal diets such as low carbohydrate intake, increased protein content, calorie restriction or the importance of dietary fats are also investigated in the available literature for possible amelioration of the ailments associated with mycotoxins exposure. It could be concluded that natural feed additives and bioactive supplements would be more safe and practical approach to combat foodborne mycotoxicoses as compared to chemical additives.

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Detoxification of ochratoxin A and zearalenone by Pleurotus ostreatus during in vitro gastrointestinal digestion

Cited by 9 publications

References 39 publications

Effect of Gastrointestinal Digestion on the Bioaccessibility of Phenolic Compounds and Antioxidant Activity of Fermented Aloe vera Juices

Effect of Gastrointestinal Digestion on the Bioaccessibility of Phenolic Compounds and Antioxidant Activity of Fermented Aloe vera Juices

Ochratoxin A: Overview of Prevention, Removal, and Detoxification Methods

Natural feed additives and bioactive supplements versus chemical additives as a safe and practical approach to combat foodborne mycotoxicoses

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