Detrimental effect of Bisphenol S in mouse germ cell cyst breakdown and primordial follicle assembly

Liu, Wen-Xiang; Farini, Donatella; Tan, Shao-Jing; Ge, Wei; Wang, Junjie; Sun, Xiao‐Feng; Cheng, Shun‐Feng; Shen, Wei

doi:10.1016/j.chemosphere.2020.128445

Cited by 13 publications

(10 citation statements)

References 67 publications

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“…At this point, there are still plenty of oocytes remaining in the ovarian cysts. Consistent with previous studies Liu et al, 2019;Liu W. X. et al, 2021;Tian et al, 2021;Wang et al, 2021), the effect of the drug on germ cell cyst breakdown and PF formation could be measured by counting the proportion of oocytes in cysts and follicles. In addition, newborn mice were fed normally after 4 days of intraperitoneal injection.…”

Section: Animals and Reagentssupporting

confidence: 58%

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Protective Mechanism of Luteinizing Hormone and Follicle-Stimulating Hormone Against Nicotine-Induced Damage of Mouse Early Folliculogenesis

Liu

Zhang

Wang

et al. 2021

Front. Cell Dev. Biol.

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Previous studies have shown that nicotine could impair the germ cell cyst breakdown and the primordial follicle assembly by autophagy. In this paper, we discovered that luteinizing hormone (LH) and follicle-stimulating hormone (FSH) could counteract the damage caused by nicotine of mouse germ cell cyst breakdown. The neonatal mice were separately intraperitoneally injected with nicotine, nicotine plus LH, nicotine plus FSH, and saline (control) for 4 days. Compared with the nicotine group, the quality of oocytes and the number of follicles were remarkably increased in the nicotine plus LH group or nicotine plus FSH group. LH and FSH could alleviate nicotine-induced oocyte autophagy by different pathways. LH reduced the nicotine-induced autophagy by restoring the phosphorylation level of adenosine 5′-monophosphate-activated protein kinase α-1, while FSH by downregulating the phosphorylation level of Forkhead box class O 1. In addition, in a subsequent study of 6-week mice in different treated groups, we found that LH and FSH supplementation significantly improved normal maturation rates, fertilization rates, and embryo’s developmental potential of oocytes in oocytes exposed to nicotine. Taken together, these results suggested that LH and FSH could counteract the damage caused by nicotine and finally ensure normal germ cell cyst breakdown and early embryo development.

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Section: Animals and Reagentssupporting

confidence: 58%

“…As previously described ( Liu W. X. et al, 2021 ), the rehydrated sections were antigen retrieved with sodium citrate and treated in 3% H 2 O 2 for 10 min. Next, sections were blocked with BDT and incubated with primary antibodies ( Supplementary Table 1 ).…”

Section: Methodsmentioning

confidence: 99%

Protective Mechanism of Luteinizing Hormone and Follicle-Stimulating Hormone Against Nicotine-Induced Damage of Mouse Early Folliculogenesis

Liu

Zhang

Wang

et al. 2021

Front. Cell Dev. Biol.

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“…BPAF compromises blood‐testis barrier integrity and sperm quality in mice, 35 and disrupts oocytes maturation in mouse in vitro through increasing oxidative stress and DNA damage 36 . BPS induces an abnormal germ cell cyst breakdown and primordial follicle assembly, affecting oocytes quality and meiotic maturation in mice 37 . BHPF, as well as BPB, was also confirmed to cause damage to female reproduction and deteriorates oocytes potential 30,31 .…”

Section: Discussionmentioning

confidence: 89%

“…36 BPS induces an abnormal germ cell cyst breakdown and primordial follicle assembly, affecting oocytes quality and meiotic maturation in mice. 37 BHPF, as well as BPB, was also confirmed to cause damage to female reproduction and deteriorates oocytes potential. 30,31 BPF, the most common bisphenol, is inevitable in daily human life.…”

Section: Comparison Of the Effects Of Bpf And Bpa On Dna Damage And O...mentioning

confidence: 92%

Bisphenol F exposure affects mouse oocyte in vitro maturation through inducing oxidative stress and DNA damage

Ding

Chen

Ahmad

et al. 2022

Environmental Toxicology

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Bisphenol F (BPF), a substitute for bisphenol A (BPA), is progressively used to manufacture various consumer products. Despite the established reproductive toxicity of BPF, the underlying mechanisms remain to elucidate. This in‐vitro study deep in sighted the BPF toxicity on mouse oocyte meiotic maturation and quality. After treating oocytes with BPF (300 μM), the oocyte meiotic progression was blocked, accentuated by a reduced rate in the first polar body extrusion (PBE). Next, we illustrated that BPF induced α‐tubulin hyper‐acetylation disrupted the spindle assembly and chromosome alignment. Concurrently, BPF resulted in severe oxidative stress and DNA damage, which triggered the early apoptosis in mouse oocytes. Further, altered epigenetic modifications following BPF exposure were proved by increased H3K27me3 levels. Concerning the toxic effects on spindle structure, oxidative stress, and DNA damage in mouse oocytes, BPF toxicity was less severe to oocyte maturation and spindle structure than BPA and induced low oxidative stress. However, compared with BPA, oocytes treated with BPF were more prone to DNA damage, indicating not less intense or even more severe toxic effects of BPF than BPA on some aspects of oocytes maturation. In brief, the present study established that like wise to BPA, BPF could inhibit meiotic maturation and reduce oocyte quality, suggesting it is not a safe substitute for BPA.

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“…Owing to the similarity of its chemical structure with endogenous estrogen (17β-estradiol; E 2 ), the toxicity of ZEA on the female reproductive system has received widespread attention [17][18][19][20]. Relevant to the present work, some papers show that the drugs can impair PF formation [21][22][23]. Other researches have reported that PF formation can be inhibited by exposure to environmental estrogens and high concentrations of E 2 , and ZEA exposure signi cantly inhibit PF formation in embryonic stage E17.5 or postnatal 0 day (PD0) mouse ovaries [24,25].…”

Section: Introductionmentioning

confidence: 80%

Impaired primordial follicle assembly in offspring ovaries from zearalenone-exposed mothers involves reduced mitochondrial activity and altered epigenetics in oocytes

Feng

Wang

et al. 2022

Cell. Mol. Life Sci.

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Previous works have shown that zearalenone (ZEA), as an estrogenic pollutant, has adverse effects on mammalian folliculogenesis. In the present study, we found that prolonged exposure of female mice to ZEA around the end of pregnancy, caused severe impairment of primordial follicle formation in the ovaries of newborn mice and altered the expression of many genes in oocytes as revealed by scRNA-seq.These changes were associated with morphological and molecular alterations of mitochondria, increased autophagic markers in oocytes, and epigenetic changes in the ovaries of newborn mice from ZEA exposed mothers. The latter increased expression of HDAC2 deacetylases was leading to decreased levels of H3K9ac and H4K12ac. Most of these modi cations were relieved when the expression of HDAC2 in newborn ovaries was reduced by RNA interference during in vitro culture in the presence of ZEA. Such changes were also alleviated in offspring ovaries from mothers treated with both ZEA and the ubiquinone coenzyme Q10 (CoQ10), which is known to be able to restore mitochondrial activities. We concluded that impaired mitochondrial activities in oocytes caused by ZEA are at the origin of metabolic alterations that modify the expression of genes controlling autophagy and primordial follicle assembly through changes in epigenetic histones.

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Detrimental effect of Bisphenol S in mouse germ cell cyst breakdown and primordial follicle assembly

Abstract: Bisphenol S (BPS) exposure results in abnormal germ cell cyst breakdown. BPS exposure activates the JNKs signaling through estrogen receptors. BPS exposure increase the proliferation of granulosa cells precursors.

Cited by 13 publications

References 67 publications

Protective Mechanism of Luteinizing Hormone and Follicle-Stimulating Hormone Against Nicotine-Induced Damage of Mouse Early Folliculogenesis

Protective Mechanism of Luteinizing Hormone and Follicle-Stimulating Hormone Against Nicotine-Induced Damage of Mouse Early Folliculogenesis

Bisphenol F exposure affects mouse oocyte in vitro maturation through inducing oxidative stress and DNA damage

Impaired primordial follicle assembly in offspring ovaries from zearalenone-exposed mothers involves reduced mitochondrial activity and altered epigenetics in oocytes

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