Detrimental Impact of Microbiota-Accessible Carbohydrate-Deprived Diet on Gut and Immune Homeostasis: An Overview

Daïen, C.; Pinget, Gabriela Veronica; Tan, Jian; Macia, Laurence

doi:10.3389/fimmu.2017.00548

Cited by 121 publications

(92 citation statements)

References 52 publications

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“…Indeed, a diet enriched in dietary fibre, which favours the growth of beneficial bacteria, has been shown to protect mice from dextran sodium sulfate (DSS) induced colitis [77], asthma [78], food allergy [79], and type 1 diabetes [80]. In contrast, dysbiosis, detrimental changes in gut microbiota resulting from a consumption of a diet deprived in dietary fibre has detrimental effects on host immunity and favours disease development [81]. The gut microbiota interacts with the host via two main mechanisms: (1) through the release of metabolites and (2) by activating innate receptors.…”

Section: Gut Microbiota and Host Physiologymentioning

confidence: 99%

Host- and Microbiota-Derived Extracellular Vesicles, Immune Function, and Disease Development

Macia

Nanan

Hosseini‐Beheshti

et al. 2019

IJMS

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175

141

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Extracellular vesicles (EVs) are blebs of either plasma membrane or intracellular membranes carrying a cargo of proteins, nucleic acids, and lipids. EVs are produced by eukaryotic cells both under physiological and pathological conditions. Genetic and environmental factors (diet, stress, etc.) affecting EV cargo, regulating EV release, and consequences on immunity will be covered. EVs are found in virtually all body fluids such as plasma, saliva, amniotic fluid, and breast milk, suggesting key roles in immune development and function at different life stages from in utero to aging. These will be reviewed here. Under pathological conditions, plasma EV levels are increased and exacerbate immune activation and inflammatory reaction. Sources of EV, cells targeted, and consequences on immune function and disease development will be discussed. Both pathogenic and commensal bacteria release EV, which are classified as outer membrane vesicles when released by Gram-negative bacteria or as membrane vesicles when released by Gram-positive bacteria. Bacteria derived EVs can affect host immunity with pathogenic bacteria derived EVs having pro-inflammatory effects of host immune cells while probiotic derived EVs mostly shape the immune response towards tolerance.

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Section: Gut Microbiota and Host Physiologymentioning

confidence: 99%

Host- and Microbiota-Derived Extracellular Vesicles, Immune Function, and Disease Development

Macia

Nanan

Hosseini‐Beheshti

et al. 2019

IJMS

Self Cite

175

141

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“…An altered microbiota, namely 'dysbiosis' can induce gut permeability and pro-inflammatory cells which could favour the development of autoimmunity [19]. The western diet, deprived in dietary fibre further favours dysbiosis and therefore the triggering of pro-inflammatory cells [20].…”

Section: Main Body Of the Articlementioning

confidence: 99%

Nutrition in RMDs: is it really food for thought? Focus on rheumatoid arthritis

et al. 2020

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Background: The relationship between food and health is known since the antiquity and in the field of rheumatic and musculoskeletal diseases (RMDs), mainly rheumatoid arthritis (RA), a large number of studies has been published over the last 50 years encompassing different aspects of nutrition. This led to postulate a role of nutrients for both primary prevention of RMDs in the general population and secondary prevention of disease flares and complications in patients with an established RMD. Main body of abstract: We aimed to summarise and critically discuss current evidence on the role of different nutrients and dietary regimens in RMDs with a focus on RA. Over the last years, some seminal papers proved that some compounds, such as salt, can directly modulate the immune system and large epidemiological studies have been linking dietary patters with the risk to develop RMDs. However, physicians' knowledge about the role of diet in disease prevention and treatment is often poor and ultimately diet is rarely perceived as a companion of pharmacological treatment. Conclusions: Based on the currently available evidence, we are not (yet?) in the phase of putting diet on the same level as pharmacological treatment in RMDs and in particular, RA, but future studies will likely shed additional light on this controversial topic and at least might suggest a value as dietary prevention of risk factors.

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“…Similarly, supplementation of diet with a brown seaweed Laminaria japonica that are higher in MACs resulted desirable shift in intestinal microbiota composition of rats through decrease in obesity-associated bacterial genera (Allobaculum, Turicibacter, Coprobacillus, Mollicute, and Oscilibacter), and bacterial genera with pathogenic potentials (Mollicute, Bacteroides, Clostridium, Escherichia, and Prevotella) and increase in Lactic acid bacteria (Subdoligranulum, Streptococcus, Lactobacillus, Enterococcus, and Bifidobacterium) [74]. Besides, a diet deprived in MACs can cause a detrimental impact on gut homeostasis and stimulate the development of different inflammatory diseases including allergies, infections, and autoimmune diseases as reviewed earlier [75].…”

Section: Effects Of Different Dietary Components On Microbial Homeostmentioning

confidence: 99%

Prokaryotes Rule the World

Adhikari¹,

Kwon²,

Hargis³

et al. 2018

Gut Microbiota - Brain Axis

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For millions of years, prokaryotic organisms have functioned as a vital selective force shaping eukaryotic evolution. It is now widely accepted that gut bacteria play a vital role in various physiological and metabolic activities of hosts, and thus, it is essential to maintain their homeostasis. Previous studies have shown an association of gut bacterial imbalance (dysbiosis) associated with several pathologies. However, very little is known about possible mechanisms involved between bacteria and hosts to maintain their homeostasis in the gut. Bacterial activities, such as cooperation (biofilm formation, horizontal gene transfer, quorum sensing, etc.), antagonism, and combination, and host responses of their immune system, gut barrier functions, and different dietary components have been identified as crucial factors for maintaining bacterial homeostasis in the gut. Our understanding of several possible mechanisms involved in gut bacterial homeostasis should be widened to modulate their composition or treat diseases. The objective of this chapter is to provide an overview of different factors involved in gut bacterial homeostasis with an emphasis on host intestinal barrier and immune system, dietary components, and quorum sensing. Also, brief information regarding roles of microbiota on gut-brain axis has also been included.

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Detrimental Impact of Microbiota-Accessible Carbohydrate-Deprived Diet on Gut and Immune Homeostasis: An Overview

Cited by 121 publications

References 52 publications

Host- and Microbiota-Derived Extracellular Vesicles, Immune Function, and Disease Development

Host- and Microbiota-Derived Extracellular Vesicles, Immune Function, and Disease Development

Nutrition in RMDs: is it really food for thought? Focus on rheumatoid arthritis

Prokaryotes Rule the World

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