Detrusor inhibition in suprasacral spinal cord injuries: is it due to sympathetic overactivity?

Mathé, J; Labat, J.-J.; Lanoiselée, Julien; Buzelin, Jean-Marie

doi:10.1038/sc.1985.36

Cited by 4 publications

References 9 publications

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Effects of guanabenz on bladder function after spinal cord injury

Sotolongo

Tomasula

Naftchi

1989

Neurourology and Urodynamics

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To the editor: Sotolongo et al. (Neurourol 8:245-254 [I 9891)Regarding the above article and the published data reported on eight feline spinal cord injury models treated on a dosage of 1.3 mg/kg of guanabenz: Comparing their urodynamic parameters (residual urine, capacity, and detrusor contraction pressure) to a control group of four untreated spinal-cord-injured animals, a significant difference was noted in all parameters between the treated and the untreated groups. In the course of a recent reanalysis of the data, however, it was noted that only three animals actually received the guanabenz at 1.3 mg/kg. In comparing their urodynamic parameters to the recalculated values for the control group, only the bladder capacity showed a trend towards a significant difference between the treatment and the control group.It has become apparent that errors were committed in our laboratory in the identification of the medications used as well as in the recorded dosage administered to the feline models. Two different analogs were used in our laboratory, and therefore the calculation of the published urodynamic parameters was not based on accurate data, since significantly fewer animals than reported actually received the guanabenz at the reported dose.

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Effects of guanabenz on bladder function after spinal cord injury

Sotolongo

Tomasula

Naftchi

1989

Neurourology and Urodynamics

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Apport d'un multicapteur pour l'exploration urodynamique

Mazieres

Yelnik

Perrigot

1999

Annales de Réadaptation et de Médecine Physique

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Bladder management

Fellows¹

1991

Spinal Cord Dysfunction: Volume II: Intervention and Treatment

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Rehabilitation — physical, occupational, and social — is the aim of management after spinal cord injury or disease. The management of the lower urinary tract is crucial, since poor treatment may lead to unacceptable morbidity or even to renal failure and premature death. There are four overlapping phases of bladder management, as expectations of improved length and quality of life for the paralysed have risen. The management of the individual patient can be considered in four stages: early management, from the moment of injury until definitive management is instituted or the patient is discharged from hospital; intermediate management, from discharge from hospital until definitive management if the latter is delayed for any reason; definitive management; and derological surveillance, which should be lifelong for all patients. Different methods of management may need to be introduced at any stage if complications arise.

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Detrusor inhibition in suprasacral spinal cord injuries: is it due to sympathetic overactivity?

Cited by 4 publications

References 9 publications

Effects of guanabenz on bladder function after spinal cord injury

Effects of guanabenz on bladder function after spinal cord injury

Apport d'un multicapteur pour l'exploration urodynamique

Bladder management

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