Deux observations de granulome annulaire sous anti-PD1

Charollais, R.; Aubin, F.; Roche-Kubler, B.; Puzenat, E.

doi:10.1016/j.annder.2017.11.005

Cited by 13 publications

(2 citation statements)

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“…This hypothesis would account for the finding of perivascular inflammatory infiltrate in virtually all GA cases [ 18 ]. Further support for this proposed mechanism has been provided by the observation of GA development following checkpoint inhibitor administration [ 17 ].…”

Section: Discussionmentioning

confidence: 97%

“…Some theories have been proposed to explain GA development. One such hypothesis is that cell-mediated reactions cause T-helper cells to differentiate into cells that express TNF-α and matrix metalloproteinases and to release interferon, which activates macrophages and causes tumor necrosis factor stimulation [ 7 , 16 , 17 ]. This theory is supported by the finding that GA can be ameliorated by downregulating the helper T cell-1 cytokine pattern with TNF inhibitors [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

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Histopathologic Aspects of Malignancy-Associated Granuloma Annulare: A Single Institution Experience

et al. 2023

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Granuloma annulare (GA) is a benign, self-limiting granulomatous inflammatory disease that exhibits different histologic patterns. Infrequently, granuloma annulare can be associated with malignancy, the so-called malignancy-associated granuloma annulare (MGA). In this study, we aimed to compare the clinical and histopathological differences between GA and MGA. We retrospectively reviewed patient charts and identified 35 patients diagnosed with GA and concurrent hematological or solid organ malignancies as a case group. Additionally, we identified 33 patients without any known solid organ or hematological malignancy as a control group. MGA is commonly seen in the seventh decade of life, while GA affects the younger population. MGA is most commonly presented in the extremities of the body. The most common malignancy associated with MGA was chronic lymphocytic leukemia. Prostate cancer was the most common type of solid organ malignancy that was associated with MGA. The most common histopathological pattern seen in MGA was interstitial, comprising half of the cases. Multinucleated giant cells were present in half of the MGA cases and in most of the control group. In the literature, there are no established features that distinguish MGA from GA. Although MGA and GA have overlapping features, in our series, we found that the interstitial pattern was more common in MGA, while the necrobiotic pattern was more common in GA.

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Section: Discussionmentioning

confidence: 97%