Drought stress and sub-optimal soil fertility management are major constraints to crop production in general and to cassava (Manihot esculenta Crantz) in particular in the rain-fed cropping systems in West Africa. Cassava is an important source of calories for millions of smallholder households in sub-Sahara Africa. The prime aim of this research was to understand cassava productivity in order to contribute to improving yields, food security and farm incomes in rain-fed cassava production systems in West Africa. A long-term goal was to contribute to a decision support tool for site-specific crop and nutrient management recommendations. Firstly, we studied farmers' perception of cassava production constraints, assessed drivers of diversity among households and analysed the suitability of farmers' resource endowment groups to the intensification of cassava production. The results indicate that farmers perceived erractic rainfall and poor soil fertility to be prime constraints to cassava production. The agricultural potential of the area and the proximity to regional markets were major drivers for the adoption of crop intensification options including the use of mineral and organic fertilizers. While the use of mineral and organic fertilizers was common in the Maritime zone that had a low agricultural potential, storage roots yields were below the national average of 2.2 Mg dry matter per hectare, and average incomes of 0.62, 0.46 and 0.46 US$ per capita per day for the high, medium and low farmer resource groups (REGs -HRE, MRE and LRE, respectively) were below the poverty line requirement of 1.25 US$. In the high agricultural potential Plateaux zone, HRE and MRE households passed this poverty line by earning 2.58 and 2.59 US$ per capita per day, respectively, unlike the LRE households with 0.89 US$ per capita per day. Secondly, we investigated the effects of mineral fertilizer on nutrient uptake, nutrient physiological use efficiency and storage roots yields of cassava since soil fertility was a major issue across the zones. We used an approach based on the model for the Quantitative Evaluation of the Fertility of Tropical Soils (QUEFTS). This model was successfully adapted for cassava and it appropriately assessed the response of cassava to N, P and K applications, especially in years with good rainfall. Under high drought stress, the model overestimated cassava yields. Thirdly, we investigated the impact of balanced nutrition on nutrient use efficiency, yield and return on investment compared to blanket fertilizer use as commonly practiced in cassava production systems in Southern Togo, and in Southern and Northern Ghana. The balanced nutrition approach of the QUEFTS model aimed to maximize simultanously nutrient use efficiency of N, P and K in accordance with the plant's needs. Larger nutrient use efficiencies of 20.5 to 23.9 kg storage root dry matter (DM) per kilo crop nutrient equivalent (1kCNE of a nutrient is the quantity of that nutrient that has the same effect on yield as 1 kg of N under balanc...