Developing a nontoxic and biocompatible polymeric self-assembly by using RAFT methodology for biomedical application

A novel trithiocarbonate reversible addition−fragmentation chain transfer (RAFT) reagent, 3‐azidopropyl (4‐[fluorosulfonyl]benzyl)trithiocarbonate (Az‐FSBCT), which has both clickable azidopropyl and sulfonyl fluoride moieties, was designed and synthesized. Using the RAFT agent Az‐FSBCT and triethylboron as an initiator, well‐defined poly(N‐vinylpyrrolidone) (PVP), in which the azide and sulfonyl fluoride groups are at the α and ω positions of the polymer chains, were prepared without prior deoxygenation at room temperature. Moreover, the possibilities for the construction of new functionalized polymers were also demonstrated by a “click” copper(I)‐catalyzed alkyne‐azide cycloaddition (CuAAC) and sulfur(VI)‐fluoride exchange (SuFEx) postreaction using these terminal functional PVPs.

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Preparation of α,ω‐heterobifunctionalized poly(N‐vinylpyrrolidone) via a bis‐clickable RAFT reagent

Liu

Sun

et al. 2022

Journal of Polymer Science

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Trithiocarbonate-mediated RAFT synthesis of a block copolymer: Silver nanoparticles integration and sensitive recognition of Hg2+

et al. 2022

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Investigation of novel diethanolamine dithiocarbamate agent for RAFT polymerization: DFT computational study of the oligomer molecules

et al. 2021

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Developing a nontoxic and biocompatible polymeric self-assembly by using RAFT methodology for biomedical application

Cited by 7 publications

References 49 publications

Preparation of α,ω‐heterobifunctionalized poly(N‐vinylpyrrolidone) via a bis‐clickable RAFT reagent

Preparation of α,ω‐heterobifunctionalized poly(N‐vinylpyrrolidone) via a bis‐clickable RAFT reagent

Trithiocarbonate-mediated RAFT synthesis of a block copolymer: Silver nanoparticles integration and sensitive recognition of Hg2+

Investigation of novel diethanolamine dithiocarbamate agent for RAFT polymerization: DFT computational study of the oligomer molecules

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