Developing curcumin into a viable therapeutic for lymphoma

Uddin, Shahab; Khan, Asma S.; Al‐Kuraya, Khawla S.

doi:10.1517/13543780802594593

Cited by 8 publications

(6 citation statements)

References 92 publications

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“…Of note, Jurkat cells have been shown to express two TIP60 variants, including one with a deleted HAT domain [ 126 ]. The natural products gallic acid and curcumin have both been shown to act as HAT inhibitors [ 127 , 128 ], and can induce proliferation arrest and apoptosis in lymphoma cells [ 129 , 130 ]. However, gallic acid and curcumin are not especially potent inhibitors of lymphoma cell growth and both have many protein targets [ 131 , 132 ]; thus, it is not clear that their effects on lymphoma cell growth are due to their anti-HAT activity.…”

Section: Introductionmentioning

confidence: 99%

Histone acetyltransferases and histone deacetylases in B- and T-cell development, physiology and malignancy

2015

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The development of B and T cells from hematopoietic precursors and the regulation of the functions of these immune cells are complex processes that involve highly regulated signaling pathways and transcriptional control. The signaling pathways and gene expression patterns that give rise to these developmental processes are coordinated, in part, by two opposing classes of broad-based enzymatic regulators: histone acetyltransferases (HATs) and histone deacetylases (HDACs). HATs and HDACs can modulate gene transcription by altering histone acetylation to modify chromatin structure, and by regulating the activity of non-histone substrates, including an array of immune-cell transcription factors. In addition to their role in normal B and T cells, dysregulation of HAT and HDAC activity is associated with a variety of B- and T-cell malignancies. In this review, we describe the roles of HATs and HDACs in normal B- and T-cell physiology, describe mutations and dysregulation of HATs and HDACs that are implicated lymphoma and leukemia, and discuss HAT and HDAC inhibitors that have been explored as treatment options for leukemias and lymphomas.

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Section: Introductionmentioning

confidence: 99%

Histone acetyltransferases and histone deacetylases in B- and T-cell development, physiology and malignancy

2015

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“…To date, most published reports on TUR or curcumin have addressed only their advantageous properties, especially their antioxidant, anti-inflammatory, and anti-cancer activities (Motterlini et al 2000;Menon and Sudheer 2007;Singh and Singh 2009;Uddin et al 2009). Those curcumin properties have been proven to be effective against many human diseases, including cancer.…”

Section: Introductionmentioning

confidence: 99%

Indirect effect of a turmeric diet: enhanced bile duct proliferation in Syrian hamsters with a combination of partial obstruction by Opisthorchis viverrini infection and inflammation by N-nitrosodimethylamine administration

et al. 2010

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The present study revealed the indirect effect of a turmeric (TUR) diet on the histopathological changes and proliferating cell nuclear antigen staining in Syrian hamsters with partial obstruction by liver fluke (Opisthorchis viverrini) infection and inflammation by N-nitrosodimethylamine (NDMA) administration. The result of the analysis of histopathological changes shows that a TUR diet has an anti-inflammatory property in the case of a single condition of NDMA administration or O. viverrini infection, as has been reported previously. Unfortunately, an adverse indirect effect of TUR was observed in the combination of infection with O. viverrini and administration of NDMA, with a 30-50% increase in new bile duct formation, correlated with an increase in proliferating cell nuclear antigen. Our present result suggests that the properties of curcumin are anti-inflammation and antioxidant including enhancing biliary contraction and bile flow. Thus, a combination of factors (treated with O. viverrini, NDMA, and TUR diet) result in an increasing bile duct proliferation which may cause from biliary homeostasis.

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“…Thus, the present study was performed to evaluate the efficacy of a traditional medicine, turmeric, whose active compound is curcumin. Turmeric is widely used for treatment of many inflammatory diseases (Motterlini et al 2000;Menon and Sudheer 2007;Singh and Singh 2009;Uddin et al 2009), as well as in animal models with opisthorchiasis. In the present study, histopathological changes and liver function tests-alanine transaminase (ALT), alkaline phosphatase (ALP), and direct bilirubin-were observed.…”

Section: Introductionmentioning

confidence: 99%

Turmeric reduces inflammatory cells in hamster opisthorchiasis

et al. 2009

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The curcumin compound from turmeric is effective in the treatment of many inflammatory diseases. The aim of our present study was to evaluate the efficacy of turmeric on reducing the histopathological changes of hamster opisthorchiasis. Hamsters were infected with Opisthorchis viverrini and then administered turmeric. Using light microscopic observation, liver function tests for alanine transaminase (ALT), alkaline phosphatase, and direct bilirubin were investigated. The resulting histopathological changes show that turmeric has anti-inflammatory properties--during both N-nitrosodimethylamine administration and O. viverrini infection--by reducing the aggregation of inflammatory cells surrounding the hepatic bile ducts, which correlates with a decreased serum ALT level. The decrease in direct bilirubin levels in the hamsters treated with turmeric suggests that turmeric may enhance biliary contraction. The present study found that turmeric clearly reduces the inflammatory cells in hamster opisthorchiasis at an early stage. This finding may be connected with a reduction in the risk factors of cholangiocarcinoma development.

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Developing curcumin into a viable therapeutic for lymphoma

Cited by 8 publications

References 92 publications

Histone acetyltransferases and histone deacetylases in B- and T-cell development, physiology and malignancy

Histone acetyltransferases and histone deacetylases in B- and T-cell development, physiology and malignancy

Indirect effect of a turmeric diet: enhanced bile duct proliferation in Syrian hamsters with a combination of partial obstruction by Opisthorchis viverrini infection and inflammation by N-nitrosodimethylamine administration

Turmeric reduces inflammatory cells in hamster opisthorchiasis

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