This study aims to explore the role of small and medium-sized enterprises (SMEs) in developing data-driven solutions to address the direct and indirect challenges posed by COVID-19. A sample of six case studies of SMEs from the UK and Portugal were selected to explore in-depth the experience of these companies in proposing innovative solutions in the pandemic context. The findings reveal that the pandemic caused amplifying effects on the digitalization of organizations and the emergence of data-driven solutions. However, the development of a data-driven approach involves not only technologies but also the digitalization of processes and highly skilled human resources. The pandemic was also a catalyst for the emergence of collaborative initiatives that have enabled the development of solutions involving diverse players from science, business, and civilian society. This study offers innovative contributions by focusing exclusively on companies developing data-driven solutions supported by technologies such as the internet of things (IoT), big data, and artificial intelligence.