Developing hyaluronic acid microgels for sustained delivery of platelet lysate for tissue engineering applications

Jooybar, Elaheh; Abdekhodaie, Mohammad J.; Karperien, Marcel; Mousavi, Abbas; Alvi, Mansour; Dijkstra, Pieter J.

doi:10.1016/j.ijbiomac.2019.10.036

Cited by 28 publications

(19 citation statements)

References 52 publications

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“…[ 141 ] Platelet bioproducts are a cost‐effective source of growth factors as it contains a high concentration of several relevant factors in wound healing, including PDGF, bFGF, VEGF, and TGF‐β. [ 142 ] Platelet bioproducts have been shown to improve regeneration of skin wounds, [ 143 ] and other soft [ 144 ] and hard tissue. [ 145 ] However, poor retention of growth factors in the wound bed and early inactivation by excessive enzymatic degradation are hindering its topical effectiveness.…”

Section: Skin Wound Healingmentioning

confidence: 99%

3D Bioprinting Constructs to Facilitate Skin Regeneration

Daikuara

Chen

Yue

et al. 2021

Adv Funct Materials

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In the last decade, the advent of 3D printing for tissue engineering and regenerative medicine has engendered great interest for those involved in skin repair and regeneration. 3D bioprinting allows spatial distribution of skin cells into predefined custom‐made structures to produce living skin mimics on the bench for grafting or drug testing. The key aspect of 3D bioprinting lies in the formulation of printable bioinks serving as matrix mimics to house skin cells, alongside an appropriate combination of cells. In this review, bioink formulations, cell combinations, as well as manufacturing methods exploited to develop 3D bioprinted constructs for skin regeneration are summarized. Issues to do with the selection of suitable materials and cells to ensure the functionality of the resulting skin constructs and fabrication of skin appendages are also addressed.

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Section: Skin Wound Healingmentioning

confidence: 99%

3D Bioprinting Constructs to Facilitate Skin Regeneration

Daikuara

Chen

Yue

et al. 2021

Adv Funct Materials

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“…Here, we highlight the properties of glycosaminoglycans (GAGs) [ 7 ], alginate [ 8 ], chitosan [ 9 ], carrageenans, ulvan, fucoidan [ 7 ], and polysaccharide derivatives (especially sulfated materials [ 10 ]). Polyanionic polysaccharides (GAGs and marine polysaccharides) have often been used to develop DDSs for cationic GFs [ 11 ] and surface coatings. Cationic polysaccharides (chitosan and its derivatives) comprise DDSs for anionic GFs [ 12 ], surface coatings, wound dressings, and scaffolds with antimicrobial properties.…”

Section: Principal Polysaccharides Used For Biomedical Materialsmentioning

confidence: 99%

Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical Applications

et al. 2021

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Polysaccharide-based materials created by physical processes have received considerable attention for biomedical applications. These structures are often made by associating charged polyelectrolytes in aqueous solutions, avoiding toxic chemistries (crosslinking agents). We review the principal polysaccharides (glycosaminoglycans, marine polysaccharides, and derivatives) containing ionizable groups in their structures and cellulose (neutral polysaccharide). Physical materials with high stability in aqueous media can be developed depending on the selected strategy. We review strategies, including coacervation, ionotropic gelation, electrospinning, layer-by-layer coating, gelation of polymer blends, solvent evaporation, and freezing–thawing methods, that create polysaccharide-based assemblies via in situ (one-step) methods for biomedical applications. We focus on materials used for growth factor (GFs) delivery, scaffolds, antimicrobial coatings, and wound dressings.

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“…Magnetic field responsive materials attain particular attention and utilization for site directed vectoring and delivery of therapeutic agents especially as cell ordering, tissue assembly, and scaffolding materials in tissue engineering applications as well as delivery of growth factors imaging and drug delivery to solid tumors in cancer treatment [130][131][132][133][134]. Biopolymers owing to their biodegradable biocompatible and safe characteristics have gained widespread utilization in tissue engineering applications [135][136][137][138]. Fan et al (2014) reported preparation of a biopolymer based magnetic nanogels of 109.4 nm by coupling heparin and CHI with adenine and thymine nucleobases and subsequent encapsulation of Fe 3 O 4 magnetic nanoparticles in self-assembled nanogels [139].…”

Section: Stimuli Responsive Micro/nanogels and Targeted Drug Deliverymentioning

confidence: 99%

Micro and Nanogels for Biomedical Applications

Can

Güven

Şahiner

2020

Hacettepe Journal of Biology and Chemistry

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D oğal ve sentetik polimerlerden geliştirilen mikro ve nano hidrojeller, yüksek yüzey alanı, yüksek derecede şişme, yüksek aktif madde yükleme kapasiteleri, yumuşaklık esneklik ve doğal dokulara benzerlikleri nedeniyle bilimsel ve endüstriyel alanda büyük ilgi görmüştür. Özellikle, biyouyumlu, toksik olmayan ve biyobozunur mikro/nano taşıyıcıların uygulamaya özgü tasarım ve fonksiyonelleştirilebilme olanakları, doku mühendisliği, biyo görüntüleme ve ilaç taşıma/teslim uygulamaları gibi çeşitli biyomedikal uygulamalar için mükemmel bir fizibilite sunmaktadır. Bununla birlikte, bu platformların in vivo ortamlardaki biyolojik bariyerleri aşabilmesi ve klinik uygulamalarda kullanıma girebilmesi için rasyonel tasarım ve işlevselleştirme stratejileri gerekmektedir. İlk olarak, ideal bir taşıyıcı biyo-uyumlu olmalı ve bağışıklık sisteminin eliminasyonundan kaçabilmeli, özellikle de istenen bölgeleri hedeflemeli ve ortam koşullarına duyarlı olarak terapötik yükü sürdürülebilir bir şekilde salabilmelidir. Mikro/nano materyal tasarımında küçük sorunlara rağmen klinik kullanıma giren birkaç başarılı formülasyon mevcuttur ve bu taşıyıcıların çoğu, tüm biyolojik kriterler için henüz tam bir başarı sağlayamamışlardır. Bu derlemede, mikro ve nanojellerin tasarım ve işlevselleştirme stratejileri özetlenerek mikro-ve nanojellerin biyomedikal uygulamalarındaki son gelişmeler, ilaç ve biyomolekül salım uygulamalarına ağırlık vererek özetlenmiştir.

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Developing hyaluronic acid microgels for sustained delivery of platelet lysate for tissue engineering applications

Cited by 28 publications

References 52 publications

3D Bioprinting Constructs to Facilitate Skin Regeneration

3D Bioprinting Constructs to Facilitate Skin Regeneration

Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical Applications

Micro and Nanogels for Biomedical Applications

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