Developing ultra deformable vesicular transportation of a bioactive alkaloid in pursuit of vitiligo therapy

Vinod, K; Anbazhagan, S.; Kumar, M Suneel; Sandhya, Subadhra; Banji, David; Rani, A. Prameela

doi:10.1016/s2222-1808(12)60066-8

Cited by 13 publications

(4 citation statements)

References 9 publications

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“…Vinod et al 170 in a recent preclinical study have evaluated repigmentation produced by a topical formulation containing piperine, with or without UV radiation, on New Zealand strain rabbits subjected to depigmentation by using 4-hydroxyanisole ointment. Although repigmentation with UV therapy plus piperine was faster in comparison with piperine cream alone, it was less homogeneous.…”

Section: Piper Nigrummentioning

confidence: 99%

The Use of Herbal Medicine in the Treatment of Vitiligo: An Updated Review

2022

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Vitiligo is a chronic disease of unknown etiology that causes progressive cutaneous depigmentation. Current pharmacological treatments have limited success and present significant risks. Many efforts have been made in recent years to explore new anti-vitiligo therapeutic strategies, including herbal-based therapies. The objective of the present review is to provide an updated overview on the most frequently used medicinal plants in the treatment of vitiligo. A bibliographical search was carried out in scientific databases Pubmed, Scifinder, Scopus, Google Scholar, and Medline up to October 2021 using the descriptors vitiligo, herbal, medicinal plants, and alternative therapies. In our search, the highest number of published studies comprise plants commonly used in traditional herbal medicine, highlighting the usefulness of ethnopharmacology in the discovery of new therapeutic agents. The review outlines current understanding and provides an insight into the role of psoralens and khellin (photosensitizing agents obtained from plants such as Cullen corylifolium or Ammi visnaga). The paper also describes other traditional herbs such as Ginkgo biloba, Phlebodium aureum, Piper nigrum, Picrorhiza kurroa, and Baccharoides anthelmintica that can likewise act as potential therapeutical agents. Based on our findings, photosensitizing agents in combination with phototherapy, the association of oral Phebodium aureum with phototherapies as well as oral G. biloba in monotherapy showed greater scientific evidence as therapeutic options. The research results emphasize that further investigation in this area is merited. More long-term follow up clinical trials and higher quality randomized trials are needed.

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Section: Piper Nigrummentioning

confidence: 99%

The Use of Herbal Medicine in the Treatment of Vitiligo: An Updated Review

2022

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“…The superficial skin was collected from the back of goat ear and the hair on the skin was removed. The dermal side of the skin was thoroughly cleaned of any adhering tissues 8 . Dermis part of the skin was wiped 3 to 4 times with a wet cotton swab soaked in isopropanol to remove any adhering fat material.…”

Section: In Vitro Skin Permeation Studiesmentioning

confidence: 99%

“…The remaining formulation adhering to the skin was scraped with a spatula. The skin surface was washed with ethanol: PBS (1:1) and then with water to remove excess drug from surface 8 . The skin was then cut into small pieces.…”

Section: In-vitro Skin Deposition Studiesmentioning

confidence: 99%

Curcumin Loaded Nano Cubosomal Hydrogel: Preparation, In Vitro Characterization and Antibacterial Activity

Archana¹,

Sri²,

Madhuri³

et al. 2015

Chem Sci Trans

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Abstract:The objective of present investigation was to develop curcumin loaded cubosomes and evaluated for topical delivery. Curcumin-loaded cubosomes were prepared by homogenization method and prepared curcumin nano cubosomes were evaluated regarding microscopic studies, particle size analysis, zeta potential, entrapment efficiency (EE%). Cubosomes hydrogels were prepared by using carbopol as gelling agent and evaluated for appearance, pH, viscosity, entrapment efficiency, in vitro drug diffuse studies, skin irritation studies and anti bacterial activity. The particle size of the formulation was about 75.2 nm and zeta potential -24 mv. The developed curcumin loaded cubosomal hydrogel gave rise to stable, nano-sized vesicles, able to improve curcumin anti bacterial activity in topical drug delivery.

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“…On the day of experiment, skin was thawed, then hairs were removed at room temperature and subcutaneous fat was removed by cotton soaked in isopropyl alcohol [27]. Thus prepared skin was cut into pieces according to the area of diffusion cell and ex vivo permeation profile of GBD from nano-transfersomes was done [28,29]. The receptor was filled with phosphate buffer: ethanol [6:4] (pH-7.4) and the prepared skin was mounted over it, with stratum corneum facing donor compartment.…”

Section: Drug Release and Permeation Profilementioning

confidence: 99%

Nano-Carrier for Accentuated Transdermal Drug Delivery

Kohli¹

2013

J Dev Drugs

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This research objective was to design a nano-carrier for Glibenclamide (GBD) by loading it in to nano-transfersomes to provide an accentuated transdermal drug delivery for Non-Insulin Dependent Diabetes Mellitus (NIDDM) The nanotransfersomes were prepared by sonication method and optimized using a statistically three-factor three-level Factorial Design (Box-Behnken design). A second order equation (polynomial) was originated and construct contour plots (2-D) for prediction the responses and characterized by various parameters (i.e. entrapment efficiency, vesicle shape & size, zeta potential, degree of deformability, permeation and skin irritation study). The skin permeation of optimized formulation (GNTs2) was found to be significantly higher (enhancement ratio is 10.44) than the drug in solution and also further confirmed by fluorescence microscopy using due i.e. Rhodamine B. Hence, drug loaded nano-transfersomes accentuates its transdermal flux and can be used as a nano-vehicle for NIDDM.

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Developing ultra deformable vesicular transportation of a bioactive alkaloid in pursuit of vitiligo therapy

Cited by 13 publications

References 9 publications

The Use of Herbal Medicine in the Treatment of Vitiligo: An Updated Review

The Use of Herbal Medicine in the Treatment of Vitiligo: An Updated Review

Curcumin Loaded Nano Cubosomal Hydrogel: Preparation, In Vitro Characterization and Antibacterial Activity

Nano-Carrier for Accentuated Transdermal Drug Delivery

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