Development and application of new methods of correction and prevention of metabolic diseases in Holstein cattle

Stepanov, I S; Kalugniy, I I; Markova, Diana; Yashin, A.V.; Prusakov, A V; Ponamarev, V. S.; Lunegov, A. M.

doi:10.1088/1755-1315/723/2/022030

Cited by 17 publications

(6 citation statements)

References 6 publications

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“…In cattle, main metabolic disorders include milk fever, ketosis, hypomagnesaemia or grass tetany, fat cow syndrome and ruminal acidosis. These conditions can cause acute, or potentially fatal deficiency (Stepanov et al 2021). Different genetic parameters which cause inherited metabolic disorders are also called inborn errors of metabolism.…”

Section: Metabolic Disordersmentioning

confidence: 99%

“…Hypomagnesaemia indicates decrease levels of blood magnesium also referred to grass tetany in dairy cattle. Reduced feed intake which is deficit in magnesium leads to twitching of muscles, shoulder and face in cows making them restless and irritable (Stepanov et al 2021). Early detection of metabolic disorders in transition cows is difficult to manage but there are different parameters which are helpful in diagnosis in order to control and treatment of metabolic disorders (Magrin et al 2020).…”

Section: Pathogenesis Of Metabolic Disordersmentioning

confidence: 99%

“…Poor feed quality and consumption of unbalanced diet are the main reasons due to which farm animals developed this syndrome. Disease develops with change in endocrine profile during calving and with the onset of milk production (Stepanov et al 2021). Clinical signs include presence of inappetence, progressive debilitation, elevated temperature, weakness and loss of body functions (Arora et al 2019).…”

Section: Fat Cow Syndromementioning

confidence: 99%

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Genetics of Metabolic Disorders in Animals

2022

Int J Vet Sci

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Section: Metabolic Disordersmentioning

confidence: 99%

Section: Pathogenesis Of Metabolic Disordersmentioning

confidence: 99%

Section: Fat Cow Syndromementioning

confidence: 99%

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Genetics of Metabolic Disorders in Animals

2022

Int J Vet Sci

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“…This causes a violation of the traditional biochemical orientation of the microflora and, as a result, the development of various metabolic disorders, in particular subclinical ketosis [9,10]. In this regard, the study of the species composition of the ruminant microbiocenosis, as well as the specific role of each species in increasing productivity of cattle, is certainly of great interest to researchers [11,12,13].…”

Section: Introductionmentioning

confidence: 99%

The T-RFLP research method in the study of rumen microbiota in dairy cows with subclinical ketosis

Yashin,

Kasatkina,

Prusakov

et al. 2023

BIO Web Conf.

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The article presents the results of researches related to the study of the possibility of using the modern molecular genetics method -T-RFLP-analysis (terminal restriction fragment length polymorphism) to identify the community of microorganisms in the contents of the rumen in clinically healthy highly productive cows and cows with subclinical ketosis. The research methodology is based on the analysis of the conservative regions in the microorganisms’ genome variability. The results showed the high efficiency of the method used for the identification of microorganisms in the rumen contents in the studied animals. A large community of bacteria, archaea, protozoa and anaerobic fungi is determined in the rumen contents from highly productive cows with subclinical ketosis. The data obtained allow us to significantly amplify the information on the pathogenesis of subclinical ketosis in cows with high milk productivity. The presence of conditionally pathogenic and pathogenic microflora in sick cows in the rumen contents indicates a violation of rumen digestion, which leads to the development of concomitant non-contagious diseases in animals.

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“…Данный процесс сопряжён со строгими регуляторно-ферментативными реакциями с негативной обратной связью, что в конечном итоге приводит к поддержанию жёлчекислотных основных доминант (называемых пулом), а также постоянством количественного и качественного состава [4][5][6][7].…”

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Enterohepatic circulation of bile acids and its role in pathologies of the hepatobiliary system

Kuznetsov,

Lunegov,

Ponamarev

et al. 2023

Vestn. Novosib. gos. agrar. univ.

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Enterohepatic circulation of bile acids is a highly regulated process of secretion of these compounds, intestinal reabsorption and reverse transport to the liver. Violation of this process has significant consequences for the homeostasis of the gastrointestinal tract, liver and the whole organism. This process is tightly controlled by regulatory enzymatic reactions with negative feedback, which leads to the maintenance of a pool and adequate homeostasis of bile acids. The main purpose of this article is to consider the mechanism of enterohepatic circulation of bile acids and evaluate their role both in the formation of pathologies of the hepatobiliary system of various origins, and as a predictor of such processes. We searched for original studies in the scientific databases PubMed, Elsevier Science (Scopus) and Clarivate Analytics (Web of Science) over the past 20 years to identify the features of the above processes, after which a formalized content analysis of the found publications was carried out. Theoretically, every factor that disrupts the enterohepatic circulation leads to pathologies of the hepatobiliary system. However, there are still many unknown aspects when it comes to the regulation of bile acid homeostasis in the enterohepatic circulation. In the last few decades, it is believed that the most important prerequisites for the occurrence of hepatopathy are hypersecretion of bile cholesterol and supersaturation of bile with it. An equally important problem is the change in the pool of bile acids, since its various representatives differ both in chemical activity and in the mechanism of action (from cytotoxicity to cytoprotection).

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Development and application of new methods of correction and prevention of metabolic diseases in Holstein cattle

Abstract: The article presents data on the periods and main reasons for the retirement of highly productive Holstein cattle at dairy farms, and offers the production of improved therapeutic and preventive measures for metabolic disorders in cows.

Cited by 17 publications

References 6 publications

Genetics of Metabolic Disorders in Animals

Genetics of Metabolic Disorders in Animals

The T-RFLP research method in the study of rumen microbiota in dairy cows with subclinical ketosis

Enterohepatic circulation of bile acids and its role in pathologies of the hepatobiliary system

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