Development and bioevaluation of nanofibers with blood-derived growth factors for dermal wound healing

Critical attributes of nanofibers: Preparation, drug loading, and tissue regeneration

“…Active pharmaceutical ingredients can be incorporated inside the nanofiber matrix, physically adsorbed, or chemically bound to the nanofiber surface. Drugs that have already been incorporated into nanofibers include antibiotics, cytostatics, protein drugs, genes, and small interfering RNAs (Bertoncelj et al, 2014;Hu et al, 2014b;Jiang et al, 2014a). The nanofiber production by electrospinning enables higher drug loading and entrapment efficiency compared to other nanodelivery systems prepared by other methods.…”

“…Bertoncelj et al proved that cell response to nanofibers is significantly altered when growth factors are incorporated. Despite the small amount of blood-derived growth factors introduced in cell culture via platelet-rich plasmaloaded nanofibers, such nanofibrillar support significantly induced cell proliferation, indicating synergistic effect of nanotopography and incorporated growth factors (Bertoncelj et al, 2014).…”

Electrospun polycaprolactone nanofibers as a potential oromucosal delivery system for poorly water-soluble drugs

“…The special characteristics of nanofibers, in addition to their very small diameters, include a high surface-to-volume ratio, a very high porosity, a small pore size, a good mechanical strength and a diversity in the surface functionalities (Huang et al, 2003;Pelipenko et al, 2013b). The drug release can be tuned for a specific application by changing the fiber's composition, production technology or the process parameters, resulting in a different fiber diameter and/or porosity (Bertoncelj et al, 2014;Sill and von Recum, 2008). The application of nanofiber mats on mucosa results in fluid absorption, due to the presence of numerous nanometer-sized interfibrillar pores.…”

Biomaterials for Skin Substitutes

“…Chitosan alone and in combination with other materials has been widely used for wound dressings and skin substitutes . It has been used in the form of both freeze‐dried sponges and hydrogels, mainly in combination with other biomaterials like collagen, gelatin, and fibrin .…”