Development and Biological Evaluation of
            <i>Gymnema Sylvestre</i>
            Extract-Loaded Nonionic Surfactant-Based Niosomes

Kamble, Bhagyashree; Talreja, Seema; Gupta, Ankur; Patil, Dada; Pathak, Deepa; Moothedath, Ismail; Basavan, Duraiswamy

doi:10.2217/nnm.12.162

Cited by 31 publications

(16 citation statements)

References 24 publications

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“…The niosomal vesicles (NS1) were observed to be subglobose under TEM (Fig. 1) (Kamble et al, 2013), and their sizes were smaller than those measured by DLS. This result agreed with the findings of previous reports (Epand et al, 2003;Perrie et al, 2007), which may be associated with the method of sample preparation, such as replica formation on a copper grid and staining for TEM.…”

Section: Characteristics Of Niosomesmentioning

confidence: 88%

Evaluation of transdermal salidroside delivery using niosomes via in vitro cellular uptake

Zhang

et al. 2015

International Journal of Pharmaceutics

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Section: Characteristics Of Niosomesmentioning

confidence: 88%

Evaluation of transdermal salidroside delivery using niosomes via in vitro cellular uptake

Zhang

et al. 2015

International Journal of Pharmaceutics

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“…A previous study determined the stability of Gymnema sylvestre extract-loaded niosome through assessing the changes occurring in color, pH, and EE% before and after 90 days of being stored at 4 ± 1 °C, 25 ± 2 °C and 37 ± 2 °C. Their results showed the formulations were found to be stable at 4 ± 1 °C ( 22 ). Much consistent with findings of the present study, another study reported similar results about the size of vesicles under the same conditions ( 35 ) and the increase in the size may be related to aggregation of vesicles during the storage time ( 40 ).…”

Section: Discussionmentioning

confidence: 99%

“…According to the International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) guidelines, Iran is categorized in zone II. As far as accelerated and intermediate testing condition is concerned, formulations were stored under three conditions such as 4 °C, 25 °C with relative humidity (RH) of 30%, and 40 °C with RH of 70% for 3 months ( 22 ). Then, vesicle sizes were examined during 24 h, 2 weeks, 1 and 3 months after preparation.…”

Section: Methodsmentioning

confidence: 99%

Development, physicochemical characterization, and antimicrobial evaluation of niosomal myrtle essential oil

Raeiszadeh¹,

Pardakhty²,

Sharififar³

et al. 2018

Res Pharma Sci

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Myrtus communis (myrtle) is well known for its therapeutic effects pertaining to the major secondary metabolites including essential oils (EOs). EOs are composed of volatile compounds and simply evaporate or decompose leading to their instability. Preparation of EOs niosomal formulation may be a promising approach to deal with these obstacles. Niosomal formulations of myrtle essential oil (nMEO) were provided using non-ionic surfactants and cholesterol (Chol). In the next steps, vesicle size, zeta potential, percentage of entrapment efficiency (EE%) and physical stability of nMEO were investigated. Finally, the effect of myrtle essential oil (MEO) and nMEO on microbial growth inhibition were assessed. Values for nMEO size and zeta potential ranged from 6.17 ± 0.32 to 7.24 ± 0.61 (μm) and -20.41 ± 0.17 to -31.75 ± 0.45 (mV), respectively. Higher degrees of EE% were obtained by F6 formulation (Span/Tween 60:Chol (50:50 molar ratio)). Moreover, niosomes have been reported to be stable at 4 °C during a three-month time period. It was revealed that nMEO F6 formulation inhibited growth of Staphylococcus aureus, Staphylococcus epidermidis, Serratia marcescens, and Bacillus subtilis at concentrations lower than that of MEO. Overall, it was found that stable multilamellar vesicles were formed in the presence of 0.5% MEO and F6 formulation. This formulation also exhibited better antibacterial activity than MEO.

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“…Based on the results of the previous studies, an increase in Span concentration of 40 will increase the entrapment efficiency of niosomes sodium ascorbyl phosphate, [23] as well as the niosome of Gymnema sylvestre extract. [25] This might be due that increasing concentration of surfactant will make the niosomes membrane less permeable and hence promotes entrapment efficiency. [5] However, after a certain point, the increase in surfactant concentration cannot increase significantly.…”

Section: Entrapment Efficiencymentioning

confidence: 99%

Untitled

Hichmah¹

2019

AJP

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Context: Aqueous extract of cassava leaves (Manihot esculenta Crantz) has a high rutin content. Rutin has benefits as an antioxidant, anti-inflammatory, analgesic, and antidiabetic. The plant extract has low bioavailability and has a large molecular weight. Therefore, a carrier system like niosomes is required to allow aqueous leaves extract of cassava through to absorb in the body. Aims: The purpose of this study was to determine the effect of variation concentration of Span 40 that can trap aqueous extract of cassava leaves in niosomes optimally. Materials and Methods: Niosomes were done by thin-layer hydration method with concentration of Span 40 which was varied into three formulas: Formula A (100 μmol), Formula B (150 μmol), and Formula C (200 μmol). Statistical Analysis Used: The data analysis using SPSS analyzed by one-way ANOVA. Results: The rutin contained in cassava leaves of this research is 42.52%. Entrapment efficiency test used dialysis membrane method and the result showed that the increased concentration of Span 40 is used; the entrapment efficiency is also increasing. The result of SPSS test using one-way ANOVA of three formulas did not show significant difference (P > 0.05). Conclusions: Optimum concentration of Span 40 in trapping aqueous extract of cassava leaves is Formula A (100 μmol) which was 95.9%.

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Development and Biological Evaluation of Gymnema Sylvestre Extract-Loaded Nonionic Surfactant-Based Niosomes

Abstract: This study reveals the merits of G. sylvestre extract-loaded niosomes, and justifies the potential of niosomes for improving the efficacy of G. sylvestre extract as antidiabetic. Original submitted 30 March 2012; Revised submitted 29 August 2012; Published online 24 December 2012.

Cited by 31 publications

References 24 publications

Evaluation of transdermal salidroside delivery using niosomes via in vitro cellular uptake

Evaluation of transdermal salidroside delivery using niosomes via in vitro cellular uptake

Development, physicochemical characterization, and antimicrobial evaluation of niosomal myrtle essential oil

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