Development and characterisation of an agar–polyvinyl alcohol blend hydrogel

Lyons, John G.; Geever, Luke M.; Nugent, Michael; Kennedy, James E.; Higginbotham, Clement L.

doi:10.1016/j.jmbbm.2008.12.003

Cited by 82 publications

(37 citation statements)

References 59 publications

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“…The in vitro release profile of the drug showed that, the release of the drug increased as the time, temperature and pH increased and reached to maximum after 48 h at pH 9 [24]. When, blending the natural polymer agar has been done with polyvinyl alcohol, the change in thermal, mechanical and swelling characteristics of the composite hydrogels has been observed [25]. Polymer blends of chitosan and poly(vinyl alcohol) when chemically crosslinked by glutaraldehyde have showed the adequate cell viability, non-toxicity and suitable mechanical properties which can further be tailored for different biomedical properties [26].…”

Section: Introductionmentioning

confidence: 98%

Radiation crosslinked polymerization of methacrylamide and psyllium to develop antibiotic drug delivery device

Singh

Sharma

Kumar

et al. 2009

International Journal of Biological Macromolecules

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Section: Introductionmentioning

confidence: 98%

Radiation crosslinked polymerization of methacrylamide and psyllium to develop antibiotic drug delivery device

Singh

Sharma

Kumar

et al. 2009

International Journal of Biological Macromolecules

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“…In recent years, our research group has been dedicated towards developing new and improved hydrogels for potential biomedical applications by synthesising and modifying both stimuli sensitive and biocompatible hydrogels [12][13][14][15][16][17][18][19][20]. The aim of this work was to prepare temperature-sensitive hydrogels that exhibit a high water uptake, pulsatile swelling and sharp thermosensitivity in the vicinity of physiological temperature, via a UV-initiated polymerisation process.…”

Section: Introductionmentioning

confidence: 99%

Photopolymerised thermo-responsive poly(N,N-diethylacrylamide)-based copolymer hydrogels for potential drug delivery applications

et al. 2012

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Novel thermo-sensitive N,N-diethylacrylamide (DEAAm) based copolymer hydrogels were prepared via UV-induced free radical bulk polymerisation. UV polymerisation was employed to avoid the use of potentially toxic solvents; solution polymerisation has been the most common means for the preparation of PDEAAm-based hydrogels in the literature to date. The resultant hydrogels were analysed using nuclear magnetic resonance, Fourier transform infrared spectroscopy and modulated differential scanning calorimetry. Parameters such as the crosslinking degree and the nature of the incorporated hydrophilic component, N-vinyl-2-pyrrolidone (NVP) or N,N-dimethylacrylamide (DMAAm) were found to impact hydrogel structure, mechanical properties and swelling kinetics. Pulsatile swelling studies indicated that the hydrogels had thermo-reversible properties which were greatly affected by test temperature, nature of hydrophilic monomer used and crosslinker content. Aminophylline was selected as a model solute for drug loading and release studies by thermal deswelling in HCl buffer (pH 1.4) and phosphate buffer media (pH 6.8). The observed lag time prior to significant drug release from the more crosslinked P(DEAAm-NVP) hydrogels could make them suitable for delayed specific release in the intestine and potential alternatives to layers or membranes in timespecific and site-specific swelling-controlled drug delivery systems.

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“…67 However, in many cases a single polymer cannot meet the requirements for a soft tissue and; therefore, blending with other polymers such as poly(ethylene oxide), agar, and polyvinyl pyrrolidone have been used. [68][69][70][71][72]…”

Section: Ic Polyvinyl Alcohol Hydrogelmentioning

confidence: 99%

Improving the homogeneity of tissue‐mimicking cryogel phantoms for medical imaging

2012

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The modified freeze-thaw process enabled to minimize the temperature gradient within the large cryogel phantoms during the freeze-thaw cycle. The results of this study can help to fill the gaps in the scientific literature with regard to developing homogeneous phantoms for medical imaging. This work also provides a solid foundation for future studies in this field and could facilitate formulating new hydrogels to replicate the viscoelastic properties of soft tissues.

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Development and characterisation of an agar–polyvinyl alcohol blend hydrogel

Cited by 82 publications

References 59 publications

Radiation crosslinked polymerization of methacrylamide and psyllium to develop antibiotic drug delivery device

Radiation crosslinked polymerization of methacrylamide and psyllium to develop antibiotic drug delivery device

Photopolymerised thermo-responsive poly(N,N-diethylacrylamide)-based copolymer hydrogels for potential drug delivery applications

Improving the homogeneity of tissue‐mimicking cryogel phantoms for medical imaging

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