Development and characterization of a snapshot Mueller matrix polarimeter for the determination of cervical cancer risk in the low resource setting

Ramella‐Roman, Jessica C.; Gonzalez, Mariacarla; Chue-Sang, Joseph; Montejo, Karla A.; Krup, Karl; Srinivas, Vijaya; DeHoog, Edward; Madhivanan, Purnima

doi:10.1117/12.2290592

Cited by 8 publications

(9 citation statements)

References 33 publications

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“…The results agreed with polarimetric imaging of healthy cervices, where there are high depolarization values for all patients. There was an exception for one patient diagnosed with a polyp, which showed lower depolarization values (as expected) [ 56 , 57 ].…”

Section: Cervical Imaging Targeted For Neoplastic Detectionsupporting

confidence: 53%

Cervical Imaging in the Low Resource Setting: A Review

et al. 2022

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Cervical cancer is one of the most significant global health inequities of our time and is the fourth most common cancer in women worldwide, disproportionally affecting developing countries where the disease burden is 84%. Sometimes referred to as preventable cancer, it progresses slowly, providing a window of time for routine screening in which pre-cancerous lesions can be identified and treated. The high mortality rate can be attributed to many reasons, including the high cost of cytology-based screening, lack of human resources to conduct screening, and inadequate preventive medicine services and systems. Due to its slow progression, early intervention is feasible with appropriate screening. However, the standard screening procedures require access to lab-based tests and physician expertise. Several imaging devices have been introduced in the literature to aid cervical screening in low-resource settings. This review details the instrumentation and clinical testing of devices currently deployed in low-resource locations worldwide. The devices' imaging, portability, illumination, and power requirements (among other metrics) are documented with specifics of human pilot studies conducted with these tools.

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Section: Cervical Imaging Targeted For Neoplastic Detectionsupporting

confidence: 53%

Cervical Imaging in the Low Resource Setting: A Review

et al. 2022

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“…Mueller matrix imaging (MMI) [38][39][40][41] has been proposed as an alternative to standard screening by several groups and focuses on subtle changes in cervical collagen structure typical of cervical precancerous lesions to provide a quantifiable map of cervical alteration in the ectocervix. For example, differences in retardance and depolarization have been shown in normal versus pathologic states.…”

Section: Introductionmentioning

confidence: 99%

Design and implementation of a portable colposcope Mueller matrix polarimeter

et al. 2020

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“…developed a snapshot Mueller matrix polarimeter that measures the polarization of collagen fibers in the cervix with the help of an LED operating at 633 nm was developed. The study reveals that any deviation from the standard polarization of collagen can indicate a diseased condition 45 . Kupinski et al.…”

Section: Optical Modalities For Cervical Cancer Detectionmentioning

confidence: 91%

“…The study reveals that any deviation from the standard polarization of collagen can indicate a diseased condition. 45 Kupinski et al developed a polarization-sensitive imaging technique while operating at 450 to 700 nm and acquiring 16 images at each wavelength to reconstruct the Mueller matrix of the sample. Radiance images acquired at 550 nm showed a low signal-to-noise ratio with high sensitivity and specificity.…”

Section: Raman Spectroscopymentioning

confidence: 99%

Optical imaging for early detection of cervical cancer: state of the art and perspectives

Rahaman,

Anantharaju,

Jeyachandran

et al. 2023

J. Biomed. Opt.

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Cervical cancer is one of the major causes of death in females worldwide. HPV infection is the key cause of uncontrolled cell growth leading to cervical cancer. About 90% of cervical cancer is preventable because of the slow progression of the disease, giving a window of about 10 years for the precancerous lesion to be recognized and treated.Aim: The present challenges for cervical cancer diagnosis are interobserver variation in clinicians' interpretation of visual inspection with acetic acid/visual inspection with Lugol's iodine, cost of cytology-based screening, and lack of skilled clinicians. The optical modalities can assist in qualitatively and quantitatively analyzing the tissue to differentiate between cancerous and surrounding normal tissues.Approach: This work is on the recent advances in optical techniques for cervical cancer diagnosis, which promise to overcome the above-listed challenges faced by present screening techniques. Results:The optical modalities provide substantial measurable information in addition to the conventional colposcopy and Pap smear test to clinically aid the diagnosis.Conclusions: Recent optical modalities on fluorescence, multispectral imaging, polarization-sensitive imaging, microendoscopy, Raman spectroscopy, especially with the portable design and assisted by artificial intelligence, have a significant scope in the diagnosis of premalignant cervical cancer in future.

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Development and characterization of a snapshot Mueller matrix polarimeter for the determination of cervical cancer risk in the low resource setting

Cited by 8 publications

References 33 publications

Cervical Imaging in the Low Resource Setting: A Review

Cervical Imaging in the Low Resource Setting: A Review

Design and implementation of a portable colposcope Mueller matrix polarimeter

Optical imaging for early detection of cervical cancer: state of the art and perspectives

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