Development and characterization of alginate / chitosan nanoparticulate system for hydrophobic drug encapsulation

Nalini, T.; Basha, Sakeenabi; Sadiq, Abdul; Kumari, V. Sugantha; Kaviyarasu, K.

doi:10.1016/j.jddst.2019.04.002

Cited by 123 publications

(41 citation statements)

References 46 publications

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“…Wasupalli and Verma found that a balance between pH solution and strong electrostatic interaction leads to the formation of nanofibers, whereas with a weaker interaction it tends to form 3 International Journal of Polymer Science nanocolloids [22]. Other reports made by Jeddi and Mahkam and Nalini et al showed the formation of nanorods using chitosan, alginate, and a highly charged agent, which confirms that a strong electrostatic interaction is working as crosslinking between polymers, which is in agreement with the results obtained in this study [26,27]. Besides, the presence of dense and agglomerated Cs-Al NDs in Figure 1(a) can be easily related to the availability of amine and carboxylic functional groups that produced strong electrostatic interaction on the surface [28].…”

Section: Resultssupporting

confidence: 92%

“…There were two stages in the cumulative amoxicillin release of the Cs-Al NDs in both pH, where initially the release increased rapidly and constantly (burst effect) in the first 2 h due to the limited distribution of the drug onto the surface, and then during the following 6 h, the release slightly decreased and became more stable [46,47]. Thereby, the release profile of amoxicillin encapsulated in Cs-Al NDs are shown to be sustainable, which is an important factor in reducing the hepatotoxicity effects and damage to healthy cells in anticancer drug delivery systems [27,48].…”

Section: Encapsulation Efficacy Andmentioning

confidence: 99%

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Ionotropic Gelation Synthesis of Chitosan-Alginate Nanodisks for Delivery System and In Vitro Assessment of Prostate Cancer Cytotoxicity

Patiño-Ruiz

Marrugo

Reyes

et al. 2020

International Journal of Polymer Science

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We report on the synthesis of chitosan-alginate nanodisks (Cs-Al NDs) using a simple approach consisting of the ionotropic gelation method. Sodium tripolyphosphate (STPP) was used as crosslinking agent to promote the electrostatic interaction between amine groups the chitosan and hydroxyl and carboxyl groups of alginate. Scanning electron microscopy (SEM) images provided direct evidence of the morphology of the nanodisks where agglomeration was observed due to the electrostatic interaction between the functional groups. Furthermore, dynamic light scattering (DLS) showed that the hydrodynamic size of the Cs-Al NDs was 227 nm and 152 nm in pH 1.2 and pH 7.4, respectively, which is in agreement with the information observed in the SEM images. The chemical structure is presented mainly the amine and carboxyl groups due to the presence of chitosan and alginate in the nanodisks, respectively, which allow the electrostatic interaction through N-H linkages. According to the X-ray diffraction, we found that the Cs-Al NDs exhibited the typical structure of chitosan and alginate, which lead the formation of polyelectrolyte complexes. We also evaluated the encapsulation of amoxicillin in the nanodisk, obtaining a loading efficiency of 74.98%, as well as a maximum in vitro release amount of 63.2 and 52.3% at pH 1.2 and 7.4, respectively. Finally, the cytotoxicity effect of the Cs-Al nanodisks was performed in human prostatic epithelial PWR-1E and Caucasian prostate adenocarcinoma PC-3 cell lines, in which the cell viability was above 80% indicating low inhibition and determining the Cs-Al NDs as a promising technology for controlled delivery systems.

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Section: Resultssupporting

confidence: 92%

Section: Encapsulation Efficacy Andmentioning

confidence: 99%

Ionotropic Gelation Synthesis of Chitosan-Alginate Nanodisks for Delivery System and In Vitro Assessment of Prostate Cancer Cytotoxicity

Patiño-Ruiz

Marrugo

Reyes

et al. 2020

International Journal of Polymer Science

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“…In particular, coating could modulate several physicochemical properties of nanoparticles, such as their aqueous solubility and viscosity as it has been confirmed by several research studies [ 187 , 188 ]. For instance, Abd-Ellatef et al [ 189 ] reported that chitosan-coated SLNs containing curcumin ( Table 4 ), were characterized by a hydrophilic surface as the lipophilic chains of chitosan fit inside the solid lipid carrier and the -OH groups were oriented outward.…”

Section: Chitosan-coated and Modified Chitosan Nanosystems Encapsumentioning

confidence: 85%

Nanosystems for the Encapsulation of Natural Products: The Case of Chitosan Biopolymer as a Matrix

et al. 2020

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Chitosan is a cationic natural polysaccharide, which has emerged as an increasingly interesting biomaterialover the past few years. It constitutes a novel perspective in drug delivery systems and nanocarriers’ formulations due to its beneficial properties, including biocompatibility, biodegradability and low toxicity. The potentiality of chemical or enzymatic modifications of the biopolymer, as well as its complementary use with other polymers, further attract the scientific community, offering improved and combined properties in the final materials. As a result, chitosan has been extensively used as a matrix for the encapsulation of several valuable compounds. In this review article, the advantageous character of chitosan as a matrix for nanosystemsis presented, focusing on the encapsulation of natural products. A five-year literature review is attempted covering the use of chitosan and modified chitosan as matrices and coatings for the encapsulation of natural extracts, essential oils or pure naturally occurring bioactive compounds are discussed.

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“…To improve the performance of water-soluble polysaccharides, chitosan coatings can be added to protect the core and prolong the release of active substances trapped inside. There are efforts in the literature to achieve these formulations and mentioned effect [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Chitosan-Coated Pectin Aerogels: Curcumin Case Study

et al. 2020

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The following study describes the preparation of pectin aerogels and pectin aerogels coated with an external layer of chitosan. For the preparation of chitosan-coated pectin aerogels, a modified coating procedure was employed. Since pectin as well as pectin aerogels are highly water soluble, a function of chitosan coating is to slow down the dissolution of pectin and consequently the release of the active substances. Textural properties, surface morphologies, thermal properties, and functional groups of prepared aerogels were determined. Results indicated that the coating procedure affected the textural properties of pectin aerogels, resulting in smaller specific surface areas of 276 m2/g, compared to 441 m2/g. However, chitosan-coated pectin aerogels still retained favorable properties for carriers of active substances. The case study for prepared aerogels was conducted with curcumin. Prior to in-vitro release studies, swelling studies were performed. Curcumin’s dissolution from both aerogels showed to be successful. Pectin aerogels released curcumin in 3 h showing a burst release profile. Chitosan-coated pectin aerogels prolonged curcumin release up to 24 h, thus showing a controlled release profile.

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Development and characterization of alginate / chitosan nanoparticulate system for hydrophobic drug encapsulation

Cited by 123 publications

References 46 publications

Ionotropic Gelation Synthesis of Chitosan-Alginate Nanodisks for Delivery System and In Vitro Assessment of Prostate Cancer Cytotoxicity

Ionotropic Gelation Synthesis of Chitosan-Alginate Nanodisks for Delivery System and In Vitro Assessment of Prostate Cancer Cytotoxicity

Nanosystems for the Encapsulation of Natural Products: The Case of Chitosan Biopolymer as a Matrix

Preparation and Characterization of Chitosan-Coated Pectin Aerogels: Curcumin Case Study

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