Development and characterization of antibacterial hydroxyapatite coated with mangosteen extract for bone tissue engineering

Chaiarwut, Sonthaya; Niyompanich, Jitti; Ekabutr, Pongpol; Chuysinuan, Piyachat; Pavasant, Prasit; Supaphol, Pitt

doi:10.1007/s00289-020-03284-3

Cited by 13 publications

(13 citation statements)

References 44 publications

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“…Hydroxyapatite is a calcium phosphate with similar crystallinities as are present in the bones. With the aid of Ag and CeO 2 , hydroxyapatite may even show antimicrobial properties [46]. Commonly, bones are classified as connective tissue; however, there some other tissues categorized within this group, such as ligaments, tendons and the dermis.…”

Section: An Overview Of Tissue Engineering (Te)mentioning

confidence: 99%

A Review of Zein as a Potential Biopolymer for Tissue Engineering and Nanotechnological Applications

Pérez-Guzmán

Castro-Muñoz

2020

Processes

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Tissue engineering (TE) is one of the most challenging fields of research since it provides current alternative protocols and materials for the regeneration of damaged tissue. The success of TE has been mainly related to the right selection of nano-sized biocompatible materials for the development of matrixes, which can display excellent anatomical structure, functionality, mechanical properties, and histocompatibility. Today, the research community has paid particular attention to zein as a potential biomaterial for TE applications and nanotechnological approaches. Considering the properties of zein and the advances in the field, there is a need to reviewing the current state of the art of using this natural origin material for TE and nanotechnological applications. Therefore, the goal of this review paper is to elucidate the latest (over the last five years) applications and development works in the field, including TE, encapsulations of drugs, food, pesticides and bandaging for external wounds. In particular, attention has been focused on studies proving new breakthroughs and findings. Also, a complete background of zein’s properties and features are addressed.

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Section: An Overview Of Tissue Engineering (Te)mentioning

confidence: 99%

A Review of Zein as a Potential Biopolymer for Tissue Engineering and Nanotechnological Applications

Pérez-Guzmán

Castro-Muñoz

2020

Processes

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“…Calcium deficiency could be the indicator of poor bone health that could result in the development of osteopenia and thus osteoporosis (Harmain et al, 2019). Bio-mimic substitute of calcium like Hydroxyapatites (HAp) from large animals is being extensively used in most parts of the world in the food industry (Chaiarwut et al, 2020). But there is a need to opt for sources according to each community suiting their pattern of consumption.…”

Section: Introductionmentioning

confidence: 99%

Development, characterization, and principal component analysis of fish bone‐based fortified refined wheat flour tortilla and its organoleptic attributes

Liaqat

Ahmed

Ali

et al. 2022

Food Processing Preservation

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This study aimed to develop nano‐sized‐biogenic hydroxyapatite (HAp) from fishbone; followed by calcination at 850°C. The core part of the research “ultra‐sonication” was done following different levels of operating variables. Characterization of resulted HAp was done using different techniques. FTIR spectra confirmed PO43− peak at 1031.77 cm−1. As per the findings of atomic absorption spectroscopy (AAS) and particle size distribution (PSD), 128.04 ± 0.19 ppm calcium and 50–400 nm particle size were determined. Scanning transmission electron microscopy (STEM) confirmed agglomerated crystal lattice, whereas in XRD 2θ crystalline behavior was noted at 300 a.u. Laser‐induced breakdown spectroscopy (LIBS) derived Ca/P‐Ratio was 1.69. HAp was further used to develop nano‐sized‐biogenic HAp fortified refined wheat flour tortillas with four formulations at 0%, 0.2%, 0.4%, and 0.6% levels. Tortilla was characterized for moisture (%) and spread ratio lied within 6.20 ± 0.05 to 8.15 ± 0.83 and 5.95 ± 0.08 to 5.80 ± 0.03, respectively. Best average acceptance was seen in a formulation named NBio‐FB1 (0.2) which could thus prove a better choice for end‐users regarding the potential to eradicate calcium deficiency. Moreover, PCA underlined 74.82% total variance. Novelty impact statement The ultrasonic processing method was practiced to reduce the particle size of HAp obtained from the discarded fish bone. With Ca/P ratio of nano‐sized‐biogenic HAp was determined by LIBS. Moreover, fortification of tortillas with nano‐sized‐biogenic HAp powders developed from fishbone may play a role to improve bone health.

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“…To overcome the cytotoxic side-effects of antibacterial agents, alternative remedies have been developed from plants. In this regard, Chaiarwut et al 138 utilized mangosteen extracts (MG) to modify the surface of HAp granules. Varying amounts of MG were loaded on the HAp: HAp-MG025 (0.025 mg/mL), HAp-MG05 (0.050 mg/mL), HAp-MG1 (0.100 mg/mL), and HAp-MG25 (0.250 mg/mL), and the average pore size of the MGcoated HAp particles was 0.427 ± 0.094 nm.…”

Section: Incorporation Of Antibacterial Agents and Antioxidantsmentioning

confidence: 99%

Multifunctional Hydroxyapatite Composites for Orthopedic Applications: A Review

George

Nayak

Singh

et al. 2022

ACS Biomater. Sci. Eng.

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Being a bioactive material, hydroxyapatite (HAp) is regarded as one of the most attractive ceramic biomaterials for bone and hard-tissue replacement and regeneration. Despite its substantial biocompatibility, osteoconductivity, and compositional similarity to that of bone, the employment of HAp is still limited in orthopedic applications due to its poor mechanical (low fracture toughness and bending strength) and antibacterial properties. These significant challenges lead to the notion of developing novel HAp-based composites via different fabrication routes. HAp, when efficaciously combined with functionally graded materials and antibacterial agents, like Ag, ZnO, Co, etc., form composites that render remarkable crack resistance and toughening, as well as enhance its bactericidal efficacy. The addition of different materials and a fabrication method, like 3D printing, greatly influence the porosity of the structure and, in turn, control cell adhesion, thereby enabling biological fixation of the material. This article encompasses an elaborate discussion on different multifunctional HAp composites developed for orthopedic applications with particular emphasis on the incorporation of functionally graded materials and antibacterial agents. The influence of 3D printing on the fabrication of HAp-based scaffolds, and the different in vitro and in vivo studies conducted on these, have all been included here. Furthermore, the present review not only provides insights and broad understanding by elucidating recent advancements toward 4D printing but also directs the reader to future research directions in design and application of HAp-based composite coatings and scaffolds.

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Development and characterization of antibacterial hydroxyapatite coated with mangosteen extract for bone tissue engineering

Cited by 13 publications

References 44 publications

A Review of Zein as a Potential Biopolymer for Tissue Engineering and Nanotechnological Applications

A Review of Zein as a Potential Biopolymer for Tissue Engineering and Nanotechnological Applications

Development, characterization, and principal component analysis of fish bone‐based fortified refined wheat flour tortilla and its organoleptic attributes

Multifunctional Hydroxyapatite Composites for Orthopedic Applications: A Review

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