Development and Characterization of Cross-Linked Poly(acrylic acid) Hydrogel Containing Drug by Radiation-Based Techniques

Jeong, Jin-Oh; Baik, Jae; An, Sung-Jun; Jeong, So Young; Lee, Jae Young; Lim, Youn-Mook; Park, Jong-Seok

doi:10.20944/preprints201801.0028.v1

Cited by 9 publications

(6 citation statements)

References 4 publications

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“…These results show that the thermal stability of the compound slightly decreases with the AAc inclusion, leaving a more significant residual mass at high temperatures. Jeong et al [ 30 ] obtained similar results using poly AAc hydrogels, which contain different metronidazole concentrations. According to the obtained thermograms, three main steps of thermal decomposition are shown: the first one is related to the evaporation of adsorbed water (weight loss about 0.2–2.7%); the second could be attributed to the destruction of poly AAc lateral groups, leading to decarboxylation or anhydride formation (weight loss of ~2.6–11.9% between 200 °C and 300 °C); and the third step is associated to main chain scission and composite depolymerization above 300 °C.…”

Section: Resultsmentioning

confidence: 75%

Wrinkling on Stimuli-Responsive Functional Polymer Surfaces as a Promising Strategy for the Preparation of Effective Antibacterial/Antibiofouling Surfaces

et al. 2021

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Biocompatible smart interfaces play a crucial role in biomedical or tissue engineering applications, where their ability to actively change their conformation or physico-chemical properties permits finely tuning their surface attributes. Polyelectrolytes, such as acrylic acid, are a particular type of smart polymers that present pH responsiveness. This work aims to fabricate stable hydrogel films with reversible pH responsiveness that could spontaneously form wrinkled surface patterns. For this purpose, the photosensitive reaction mixtures were deposited via spin-coating over functionalized glasses. Following vacuum, UV, or either plasma treatments, it is possible to spontaneously form wrinkles, which could increase cell adherence. The pH responsiveness of the material was evaluated, observing an abrupt variation in the film thickness as a function of the environmental pH. Moreover, the presence of the carboxylic acid functional groups at the interface was evidenced by analyzing the adsorption/desorption capacity using methylene blue as a cationic dye model. The results demonstrated that increasing the acrylic acid in the microwrinkled hydrogel effectively improved the adsorption and release capacity and the ability of the carboxylic groups to establish ionic interactions with methylene blue. Finally, the role of the acrylic acid groups and the surface topography (smooth or wrinkled) on the final antibacterial properties were investigated, demonstrating their efficacy against both gram-positive and gram-negative bacteria model strains (E. coli and S. Aureus). According to our findings, microwrinkled hydrogels presented excellent antibacterial properties improving the results obtained for planar (smooth) hydrogels.

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Section: Resultsmentioning

confidence: 75%

Wrinkling on Stimuli-Responsive Functional Polymer Surfaces as a Promising Strategy for the Preparation of Effective Antibacterial/Antibiofouling Surfaces

et al. 2021

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“…In addition, water in the polymer solution played a crucial role in realizing maximum crosslinking, resulting in a higher number of free radicals, thereby improving the generation of macroradicals. Furthermore, H atoms and –OH radicals can produce additional macroradicals by eliminating H from PVA molecules (Jeon et al 2018 ). During irradiation, radical crosslinking and chain scission are two main reactions that simultaneously occur.…”

Section: Resultsmentioning

confidence: 99%

Characterization of pH-responsive high molecular-weight chitosan/poly (vinyl alcohol) hydrogel prepared by gamma irradiation for localizing drug release

Piroonpan

Preuksarattanawut

et al. 2022

Bioresour. Bioprocess.

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AbstractpH-sensitive hydrogels prepared by gamma irradiation find promising biological applications, partially, in the field of localized drug liberation. Herein, optimal conditions for fabricating high-molecular-weight chitosan/polyvinyl alcohol hybrid hydrogels using gamma irradiation at 10, 25, and 30 kGy were investigated by studying the water uptake behavior, the pore size on the surface, and thermal stability. Furthermore, the crosslinking mechanism of irradiated hydrogels was examined via solid-state 13C NMR spectrum. The swelling ratio of the gamma-irradiated CS/PVA hydrogel was pH-dependent; particularly, the hybrid hydrogel exhibited high swelling ratios under acidic conditions than those under basic conditions due to the protonation of amino groups on CS-backbone in acidic environments. In addition, amoxicillin was used as a model drug in the in vitro drug release investigations in pH-simulated gastric fluid and deionized water at 37 °C. To identify the drug release mechanism, several kinetic models composing zero-order, first-order, Higuchi, Hixson–Crowell, and Korsmeyer–Peppas models were used. The findings suggested that drug release is mediated by a non-Fickian transport mechanism. Graphical Abstract

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“…This observation is consistent with literature reports indicating 37,38 that the immediate crosslinking of layers in TF designs achieves thinner and more distinct PAA layers compared to IDN designs. Additionally, it was also observed that the surfaces of the PAA top layers for TF designs were brittle and fragmented after exposure to both acidic and basic environments (Figure 3), suggesting the presence of a free PAA network at the surface since the pure PAA hydrogel is well known to have poor mechanical properties, 39 especially in a basic environment. 40,41 In contrast, the PVA network combined with PAA in the interfacial layer enabled the IDN design to maintain structural and morphological stability during the changes in pH.…”

Section: Resultsmentioning

confidence: 99%

Polyvinyl alcohol-poly acrylic acid bilayer oral drug delivery systems: A comparison between thin films and inverse double network bilayers

et al. 2019

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Polymer network structures in the design of bilayer hydrogels for oral drug delivery systems contribute to the mechanical stability as well as the stimulus responsive drug release. We report a strategy to improve the stability of polyelectrolyte layer interfaces in bilayer hydrogels by employing concepts from tough interpenetrating hydrogel network design. Polyvinyl alcohol as the neutral substrate and Polyacrylic acid as the pH-sensitive layer were used to prepare bilayers capable of pH-sensitive bending behavior, and inverse double network structures were compared to conventional thin film coated bilayers in this study. The morphology of the bilayers observed after exposure to stimulus revealed that the polyacrylic acid layer was fragmented in conventional thin films. The delamination of the coating also had an adverse impact on bending behavior. Additionally, bilayers with inverse double network structure had a better pH-sensitive swelling behavior which was lacking in regular thin films. Controllable, pH-specific drug release behavior was a direct benefit of using the inverse double network structure, and was demonstrated by controlled vancomycin release under different pHs chosen to simulate the physiological milieu of exposure corresponding to hydrogel passage along the gastrointestinal tract. Additionally, the inverse double networks showed improved mucoadhesive properties and mechanical stability compared to the thin film bilayers. The use of inverse double network structured hydrogels has many potential applications in improving bilayer hydrogel stability; specifically, for drug delivery systems, designing hydrogel origamis, and to prepare soft material actuators.

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Development and Characterization of Cross-Linked Poly(acrylic acid) Hydrogel Containing Drug by Radiation-Based Techniques

Abstract: Poly(acrylic acid) (PAAc) hydrogels possess good bioadhesive properties and allow 15 enhanced penetration of drugs. In addition, it is possible to localize the absorption site of the

Cited by 9 publications

References 4 publications

Wrinkling on Stimuli-Responsive Functional Polymer Surfaces as a Promising Strategy for the Preparation of Effective Antibacterial/Antibiofouling Surfaces

Wrinkling on Stimuli-Responsive Functional Polymer Surfaces as a Promising Strategy for the Preparation of Effective Antibacterial/Antibiofouling Surfaces

Characterization of pH-responsive high molecular-weight chitosan/poly (vinyl alcohol) hydrogel prepared by gamma irradiation for localizing drug release

Polyvinyl alcohol-poly acrylic acid bilayer oral drug delivery systems: A comparison between thin films and inverse double network bilayers

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