Development and characterization of gelatin-tamarind gum/carboxymethyl tamarind gum based phase-separated hydrogels: a comparative study

Shaw, Gauri Shankar; Uvanesh, K.; Gautham, S.N.; Singh, Vinay Kumar; Pramanik, Krishna; Banerjee, Indranil; Kumar, Naresh; Pal, Kunal

doi:10.1080/15685551.2015.1041075

Cited by 31 publications

(21 citation statements)

References 28 publications

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“…It has been used in the development of various drug delivery systems due to its hydrophilic and bioadhesive properties [21][22][23][24][25][26][27] . Although TG shows presence of non-sterically hindered hydroxyl groups, very few reports mentioned the use of pure TG in chemically crosslinked hydrogels [28] . Moreover, TG can be used as a cheaper alternative to HEC for the preparation of citric acid crosslinked CMC-based hydrogels.…”

Section: Research Papermentioning

confidence: 99%

Citric Acid Crosslinked Carboxymethyl Cellulose-based Composite Hydrogel Films for Drug Delivery

Mali¹,

Dhawale²,

Dias³

et al. 2018

pharmaceutical-sciences

104

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Mali et al.: Carboxymethyl cellulose-based hydrogel films for drug deliveryThe objective of this study was to synthesize and characterize citric acid crosslinked hydrogel films of carboxymethyl cellulose-tamarind gum for topical drug delivery. The hydrogel films were characterized by attenuated total reflectance-Fourier-transform infrared spectroscopy, solid-state 13 C-nuclear magnetic resonance spectroscopy and differential scanning calorimeter. The prepared hydrogel films were evaluated for the carboxyl content and equilibrium swelling ratio. Moxifloxacin hydrochloride was loaded into these hydrogel films and drug release was monitored in the phosphate buffer pH 7.4. Haemolysis assay was used to study biocompatibility of hydrogel films. Results of the attenuated total reflectance-Fourier-transform infrared spectroscopy, solid-state 13 C-nuclear magnetic resonance and differential scanning calorimeter confirmed the formation of citric acid-crosslinked hydrogel films. Total carboxyl content of hydrogel film was found to be increased when polymer ratio and amount of citric acid was increased. In contrast, swelling of hydrogel film was found to be decreased with increase in polymer ratio and amount of citric acid. Batch B1 showed highest drug loading with non-Fickian release mechanism. All remaining batches showed nonFickian release behavior with diffusion coefficient greater than 0.5. Results of haemolysis assay indicated that the citric acid crosslinked carboxymethyl cellulose-tamarind gum hydrogels were safe to be used in drug delivery. These results indicated that the citric acid crosslinked carboxymethyl cellulose-tamarind gum composite hydrogel film has the potential to be used in topical novel drug delivery systems.

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Section: Research Papermentioning

confidence: 99%

Citric Acid Crosslinked Carboxymethyl Cellulose-based Composite Hydrogel Films for Drug Delivery

Mali¹,

Dhawale²,

Dias³

et al. 2018

pharmaceutical-sciences

104

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“…The estimation of the effect of the phenomenon may be predicted from the Weichert model (Figure 3(f )) (Equation (5)). [37] The percentage of SR (%SR; Equation (4)) for F1, F2, F3, F4, F5, and F6 was 54.68, 69.54, 59.99, 61.93, 70.23, and 58.46%, respectively. The result suggested that, in general, there was an increase in the SR when PLLA was introduced into the scaffolds.…”

Section: Swelling Studymentioning

confidence: 99%

Evaluation of poly(L-lactide) and chitosan composite scaffolds for cartilage tissue regeneration

Mallick

Pal

Rastogi

et al. 2016

Designed Monomers and Polymers

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The present study delineates the development of chitosan and poly(L-lactide) (PLLA) scaffolds cross-linked using a mixture of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC), n-hydroxysuccinimide (NHS), and chondroitin sulfate (CS) for cartilage tissue engineering applications. Chitosan and PLLA were varied in concentration for developing scaffolds and prepared by freeze-drying method. The various scaffolds were studied using scanning electron microscopy (SEM), porosity by mercury intrusion porosimeter, and the molecular interactions among polymers using Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) studies. Differential scanning calorimetry (DSC) was used to predict the thermal properties of the scaffolds. The mechanical properties of the scaffolds were studied using static mechanical tester. The ability of the scaffolds to support chondrocyte proliferation was also studied. The microscopy suggests that the pore size of the scaffolds varied with the composition in the range of 38-172 μm and the porosities in the range of 73-93%. The XRD and the FTIR studies suggested that an alternation in the composition of the scaffolds altered the molecular interactions among the scaffold components. An increase in the chitosan content enhanced the swelling property. The degradation of the scaffolds was least when the proportion of chitosan and PLLA was in the ratio of 70:30. The in vitro cell proliferation study suggested that the developed scaffolds were able to support chondrogenesis, the glycosaminoglycan (GAG) content of the mature chondrocyte was 40 μg/ml and the viability was approximately 90%. Hence, the so designed scaffolds may be tried for cartilage tissue engineering applications.

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“…[46][47][48][49][50] Because of these properties, it is also in preparation of hydrogels. [51][52][53] Tamarind seed polysaccharide is found non-irritant with haemostatic activity. 54 It has shown hepatoprotective activity also.…”

Section: Chemical Composition and Propertiesmentioning

confidence: 99%

Tamarind Seed Polysaccharide: An Emerging Excipient for Pharmaceutical Use

Nayak¹,

Pal²

2017

IJPER

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Currently, various plant polysaccharides have been studied for their diverse applications as excipients like binders, granulating agents, disintegrants, emulsifiers, suspending agents, gelling agents, mucoadhesive agents, matrix-formers, release retardants, enteric resistants, etc., in various pharmaceutical dosage forms. Among these, tamarind seed polysaccharide is an emerging excipient, which is beingused and investigated for the preparation of various dosage forms like suspensions, emulsions, tablets, gels, creams, beads, spheroids, microparticles, nanoparticles, ophthalmic preparations, and buccal patches, etc. The current chapter deals with a comprehensive and useful discussion on pharmaceutical applications of tamarind seed polysaccharide withits some important features like source, isolation, chemical composition and properties.

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Development and characterization of gelatin-tamarind gum/carboxymethyl tamarind gum based phase-separated hydrogels: a comparative study

Cited by 31 publications

References 28 publications

Citric Acid Crosslinked Carboxymethyl Cellulose-based Composite Hydrogel Films for Drug Delivery

Citric Acid Crosslinked Carboxymethyl Cellulose-based Composite Hydrogel Films for Drug Delivery

Evaluation of poly(L-lactide) and chitosan composite scaffolds for cartilage tissue regeneration

Tamarind Seed Polysaccharide: An Emerging Excipient for Pharmaceutical Use

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