Development and characterization of mucoadhesive chitosan films for ophthalmic delivery of cyclosporine A

Hermans, Kris; plas, D. Van den; Kerimova, Sabina; Carleer, Robert; Adriaensens, Peter; Weyenberg, Wim; Ludwig, Annick

doi:10.1016/j.ijpharm.2014.06.017

Cited by 64 publications

(32 citation statements)

References 44 publications

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“…entry of the release medium into the matrix, swelling, dissolution of the drug in the medium, drug diffusion through the hydrated matrix and film erosion. This matter could explain that multiphase release profile was obtained for PC2Cs2 (3,29).…”

Section: Discussionmentioning

confidence: 81%

Preparation, Characterization and Evaluation of Antifungal Efficacy of Chitosan/Soy Phosphatidylcholine Topical Films Containing Griseofulvin

Bavarsad

Kouchak

Varmaziar

et al. 2015

Jundishapur J Nat Pharm Prod

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Background:Griseofulvin is an antifungal drug and is available as oral dosage forms. Development of topical treatment could be advantageous for superficial fungal infections of skin. The film forming property of chitosan has made it interesting for transdermal/ dermal drug delivery, but showed lack of stability. Soy phosphatidylcholine (PC), besides playing penetration enhancer and solubilizer roles, could enhance the stability and mechanical properties of the film. Films prepared from a mixture of chitosan and PC can achieve the benefits of both materials. Objectives: The aim of this study was to prepare and characterize films formed from blends of chitosan and soy PC for topical delivery of griseofulvin. Materials and Methods: Topical films composed of chitosan and soy PC were prepared by means of casting and solvent evaporation technique. The properties of the films were characterized regarding mechanical properties, swelling, ability to transmit vapor, drug release, thermal behavior and antifungal efficacy against Microsporum gypseum and Epidermophyton floccosum. Results: Presence of soy PC improved mechanical properties, lowered swelling ratio and increased stability of the films. Solubilizing activity of phospholipid resulted in higher flux of drug release from formulation containing higher amount of soy PC. Antifungal efficacy of formulations was confirmed against two species of dermatophytes in vitro. Conclusions: This topical composite film had the potential for griseofulvin delivery to superficial fungal infections.

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Section: Discussionmentioning

confidence: 81%

Preparation, Characterization and Evaluation of Antifungal Efficacy of Chitosan/Soy Phosphatidylcholine Topical Films Containing Griseofulvin

Bavarsad

Kouchak

Varmaziar

et al. 2015

Jundishapur J Nat Pharm Prod

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“…For example, it has been reported that the CS is positively charged at a physiological pH (pH 7.4), and it may develop molecular attraction forces by electrostatic interactions with the negative charge of the cornea to increase the drug retention time [3,18]. Currently, there are a number of reports of CS being extensively used as a mucoadhesive in ocular drug delivery systems [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

The potential use of novel chitosan-coated deformable liposomes in an ocular drug delivery system

Chen

Pan

et al. 2016

Colloids and Surfaces B: Biointerfaces

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“…However the presence hydroxypropylb-cyclodextrin did not significantly affect the cyclosporine A release from the films prepared. The authors concluded that the release mechanism was the drug diffusion through the swollen polymer matrix and the incomplete release was explained by the lack of influence of this parameter on the film swelling properties [54].…”

Section: In Vitro Release Studiesmentioning

confidence: 99%

Novel nanostructured lipid carrier-based inserts for controlled ocular drug delivery: evaluation of corneal bioavailability and treatment efficacy in bacterial keratitis

Okur

Gökçe

Bozbıyık

et al. 2015

Expert Opinion on Drug Delivery

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Development and characterization of mucoadhesive chitosan films for ophthalmic delivery of cyclosporine A

Cited by 64 publications

References 44 publications

Preparation, Characterization and Evaluation of Antifungal Efficacy of Chitosan/Soy Phosphatidylcholine Topical Films Containing Griseofulvin

Preparation, Characterization and Evaluation of Antifungal Efficacy of Chitosan/Soy Phosphatidylcholine Topical Films Containing Griseofulvin

The potential use of novel chitosan-coated deformable liposomes in an ocular drug delivery system

Novel nanostructured lipid carrier-based inserts for controlled ocular drug delivery: evaluation of corneal bioavailability and treatment efficacy in bacterial keratitis

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