Development and characterization of pioglitazone loaded liposphere for the effective treatment of diabetes mellitus type 2

Payasi, Mithilesh; Bhowmick, Mithun; Pandey, Girijesh Kumar; Joshi, Amit; Dubey, Balkrishna

doi:10.7439/ijbar.v4i10.553

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…Their advantages over other DDS (emulsions, liposomes, and polymer nanoparticles) include physical stability, being easy to disperse in aqueous medium, simple preparation, high retention of hydrophobic drugs in the core, and prolonged delivery [102]. Lipospheres have been used for the delivery of several classes of drugs, such as local anesthetics [99], anti-inflammatories [100], antineoplastic [101], immunosuppressant [102], hypoglycemic agents [103], antimalarial agents [104], and antihypertensive agents [105].…”

Section: Innovative Hybrid Lipid Nanoparticles: Solid Lipid Nanopartimentioning

confidence: 99%

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Ribeiro

Alcántara

Silva

et al. 2017

International Journal of Polymer Science

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The use of biomaterials composed of organic pristine components has been successfully described in several purposes, such as tissue engineering and drug delivery. Drug delivery systems (DDS) have shown several advantages over traditional drug therapy, such as greater therapeutic efficacy, prolonged delivery profile, and reduced drug toxicity, as evidenced by in vitro and in vivo studies as well as clinical trials. Despite that, there is no perfect delivery carrier, and issues such as undesirable viscosity and physicochemical stability or inability to efficiently encapsulate hydrophilic/hydrophobic molecules still persist, limiting DDS applications. To overcome that, biohybrid systems, originating from the synergistic assembly of polymers and other organic materials such as proteins and lipids, have recently been described, yielding molecularly planned biohybrid systems that are able to optimize structures to easily interact with the targets. This work revised the biohybrid DDS clarifying their advantages, limitations, and future perspectives in an attempt to contribute to further research of innovative and safe biohybrid polymer-based system as biomaterials for the sustained release of active molecules.

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